Navegando por Autor "Furtado, Raimundo"
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Artigo Bioinformatics analysis of the human surfaceome reveals new targets for a variety of tumor types(Hindawi, 2016-10-18) Fonseca, André L.; Silva, Vandeclécio Lira da; Fonseca, Marbella M.; Meira, Isabella Tanus Job e; Silva, Thayná Emília Oliveira; Kroll, José Eduardo; Ribeiro-dos-Santos, André M.; Freitas, Cléber R.; Furtado, Raimundo; Souza, Jorge Estefano Santana de; Ferreira, Beatriz Stransky; Souza, Sandro José deIt is estimated that 10 to 20% of all genes in the human genome encode cell surface proteins and due to their subcellular localization these proteins represent excellent targets for cancer diagnosis and therapeutics. Therefore, a precise characterization of the surfaceome set in different types of tumor is needed. Using TCGA data from 15 different tumor types and a new method to identify cancer genes, the -score, we identified several potential therapeutic targets within the surfaceome set. This allowed us to expand a previous analysis from us and provided a clear characterization of the human surfaceome in the tumor landscape. Moreover, we present evidence that a three-gene set—WNT5A, CNGA2, and IGSF9B—can be used as a signature associated with shorter survival in breast cancer patients. The data made available here will help the community to develop more efficient diagnostic and therapeutic tools for a variety of tumor typesArtigo Bioinformatics Analysis of the Human Surfaceome Reveals New Targets for a Variety of Tumor Types(2016-10-18) Fonseca, André L.; Silva, Vandeclécio L. da; Fonseca, Marbella M.; Meira, Isabella T. J.; Silva, Thayná E. da; Kroll, José Eduardo; Ribeiro-dos-Santos, André M.; Freitas, Cléber R.; Furtado, Raimundo; Souza, Sandro José de; Ferreira, Beatriz Stransky; Souza, Sandro José deIt is estimated that 10 to 20% of all genes in the human genome encode cell surface proteins and due to their subcellular localization these proteins represent excellent targets for cancer diagnosis and therapeutics. Therefore, a precise characterization of the surfaceome set in different types of tumor is needed. Using TCGA data from 15 different tumor types and a new method to identify cancer genes, the -score, we identified several potential therapeutic targets within the surfaceome set. This allowed us to expand a previous analysis from us and provided a clear characterization of the human surfaceome in the tumor landscape. Moreover, we present evidence that a three-gene set—WNT5A, CNGA2, and IGSF9B—can be used as a signature associated with shorter survival in breast cancer patients. The data made available here will help the community to develop more efficient diagnostic and therapeutic tools for a variety of tumor types.Artigo Graph analysis of dream reports is especially informative about psychosis(2014-01-15) Mota, Natália B.; Furtado, Raimundo; Maia, Pedro P. C.; Copelli, Mauro; Ribeiro, Sidarta Tollendal GomesEarly psychiatry investigated dreams to understand psychopathologies. Contemporary psychiatry, which neglects dreams, has been criticized for lack of objectivity. In search of quantitative insight into the structure of psychotic speech, we investigated speech graph attributes (SGA) in patients with schizophrenia, bipolar disorder type I, and non-psychotic controls as they reported waking and dream contents. Schizophrenic subjects spoke with reduced connectivity, in tight correlation with negative and cognitive symptoms measured by standard psychometric scales. Bipolar and control subjects were undistinguishable by waking reports, but in dream reports bipolar subjects showed significantly less connectivity. Dream-related SGA outperformed psychometric scores or waking-related data for group sorting. Altogether, the results indicate that online and offline processing, the two most fundamental modes of brain operation, produce nearly opposite effects on recollections: While dreaming exposes differences in the mnemonic records across individuals, waking dampens distinctions. The results also demonstrate the feasibility of the differential diagnosis of psychosis based on the analysis of dream graphs, pointing to a fast, low-cost and language-invariant tool for psychiatric diagnosis and the objective search for biomarkers. The Freudian notion that “dreams are the royal road to the unconscious” is clinically useful, after all.