Navegando por Autor "Girão, Ícaro Chaves"
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TCC Hydrogel lens for incorporation of Brimonidine Tartrate: a pre-formulation study(Universidade Federal do Rio Grande do Norte, 2025-01-10) Medeiros, Mariana Maressa Ferreira de; Girão, Ícaro Chaves; Sousa, Fabia Julliana Jorge de; Oliveira, Douglas Dourado; Oliveira, Wógenes Nunes de; Egito, Eryvaldo Sócrates Tabosa do; Egito, Eryvaldo Sócrates Tabosa do; Oliveira, Wógenes Nunes de; http://lattes.cnpq.br/1190614005046544; http://lattes.cnpq.br/6907806915889763; http://lattes.cnpq.br/5460829943851936; Alencar, Éverton do Nascimento; http://lattes.cnpq.br/0168495853673885; Silva, André Leandro; http://lattes.cnpq.br/0712488767870940Approximately 11.9 million people suffer from vision impairment or blindness due to glaucoma, a condition characterized by progressive optic nerve damage that primarily affects peripheral vision and can lead to blindness. The brimonidine tartrate (BRT) eye drops, a third-generation alpha-adrenergic agonist, are commonly used for glaucoma treatment, however present (i) side effects, (ii) low ocular availability (1-7%), (iii) nasolacrimal drainage and (iv) compliance issues that compromise its continuous use, leading to the therapeutic inefficacy. Then, new drug delivery systems, such as hydrogel contact lenses, may improve the patient compliance, and promote suitable ocular drug delivery. Based on this, the aim of this study was to produce and characterize brimonidine tartrate-loaded hydrogel lenses (BRTHL). The BRTHL was prepared by dissolving PVA at 90 ºC, followed by the addition of sodium hydroxide and sodium trimetaphosphate for crosslinking, followed by BRT incorporation during the manufacturing process. Posteriorly, the BRTHL was evaluated concerning the drug entrapment efficiency by UV-Vis spectrophotometry, in addition to light transmittance, thickness measurements, swelling behavior and Fourier transform infrared spectroscopy (FTIR). The BRTHL demonstrated an average drug entrapment efficiency of 72% ± 7.72%, which corresponds to 4.00 ± 0.35 µg/mg of hydrogel, a value similar to the commercial BRT eye drops. The BRTHL exhibited over 95% of transmittance, indicating adequate optical clarity. The thickness measurements were within optimal ranges for oxygen permeability and showed an average of 0.192 ± 0.010 mm. The swelling behavior of the hydrogels showed efficient water absorption, supporting potential drug release. The FTIR results indicated the success of the crosslink process. Then, the developed BRTHL exhibited suitable physical and chemical properties, effective drug loading, and satisfactory light transmittance. The obtained results demonstrate their potential for ocular use, paving the way to its further use as a novel drug delivery system for BRTTCC Linseed oil microemulsion for ivermectin delivery: production and biosafety assessment(Universidade Federal do Rio Grande do Norte, 2024-06-19) Girão, Ícaro Chaves; Cruz, Yasmin Ferreira; Miranda, Júlio Abreu; Oliveira, Wógenes Nunes; Egito, Eryvaldo Sócrates Tabosa do; Egito, Eryvaldo Sócrates Tabosa do; Oliveira, Wógenes Nunes; Veríssimo, Lourena Mafra; Machado, Lucas AmaralIvermetcin (IVM) is an antiparasitic drug used worldwide due to its broad spectrum of action and low cost. However, the current drug dosage forms for IVM present drawbacks that compromises the treatment, as difficulties in administration in animals and limited skin permeation. Then, the aim of this work is to produce a microemulsion to deliver IVM for the treatment of parasitic infections in dogs. The IVM microemulsion (IVM-MeLO) composed by purified water (70 %), linseed oil (5 %), Kolliphor® RH40 (21.75 %), Span® 80 (3.25 %) and IVM (1.95 %) was produced and characterized by hydrodynamic diameter, polydispersity index (PdI), pH, conductivity, entrapment efficiency in addition to the physicochemical and chemical stability, and hemolytic potential. Results indicated that the IVM-MeLO exhibited hydrodynamic diameter of 21.7 ± 0.2 nm, PdI of 0.10 ± 0.01, pH value of 5.3 ± 0.05, electrical conductivity of 318 ± 2.00 μS.cm-1 and entrapment efficiency 93.92 ± 3.76%, data related to the microemulsified systems features. The IVM also did not showed any instability phenomena in the stability study conducted. In addition, no hemolytic effect was observed, suggesting a promising biocompatibility. These findings highlight the potential of the IVM-MeLO as a non-toxic and stable formulation, which can be used in further studies as an alternative for cutaneous parasitic infections.