Navegando por Autor "Goldenberg, Alberto"

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Adhesion prevention in reabsorbable polyethylene glycol hydrogel (Coseal®) coated polypropylene mesh in rabbits
(Acta Cirurgica Brasileira, 2013-12) Quinino, Reynaldo Martins e; Araújo Filho, Irami; Lima, Francisco Piganataro; Barbosa, André Luís Costa; Maia, Tatiana de Carvalho; Goldenberg, Alberto; https://orcid.org/0000-0002-4284-2543
Purpose: To evaluate of postoperative adhesion prevention and inflammatory response to polypropylene mesh, coated with reabsorbable hydrogel of polyethylene glycol (Coseal®) in contact with small bowel in an experimental model in rabbits. Methods: Twenty female rabbits underwent laparotomy to implant two polypropylene meshes, 2x1cm, in the right and left flanks. The right mesh was protected with Coseal® spray (Group 1) and the left mesh received no treatment after implantation (Group 2). Thirty days after implantation, the rabbits underwent laparoscopy for adhesion analysis; the prosthesis were removed en bloc with the adjacent tissue for microscopic analysis of inflammation. Statistical analysis used the Mann-Whitney test. RESULTS: There was adhesion formation in five meshes (36%) from Group 1 and in 14 meshes (100%) from Group 2, with statistical significance (p<0.01). There were no differences in the inflammatory response, fibrosis, foreign body reaction, presence of collagen and type of inflammatory cells between the two groups. Conclusion: Polypropylene mesh coated with Coseal® showed a significantly lower rate of adhesion formation when compared with uncoated meshes, without interfering with inflammatory response.
Analysis of the immunohistochemical expression of ghrelin in the gastric mucosa and correlation with weight loss after sleeve gastrectomy
(Springer, 2022-09-23) Quinino, Reynaldo Martins e; Barbosa, André Luis Costa; Xavier, Maíra de Araújo Barros; França, Romero de Lima; Freitas, Mirella Patrícia Cruz de; Goldenberg, Alberto; https://orcid.org/0000-0002-4284-2543
Introduction Sleeve gastrectomy is one of the main techniques used to treat severe obesity. The study of the immunohistochemical expression of ghrelin in the gastric mucosa has already been related to weight loss and can be a promising method to predict the surgical outcome. Purpose To analyze the immunohistochemical expression of ghrelin in the gastric mucosa and its correlation with weight loss, comorbidities, and infammatory changes after sleeve gastrectomy. Methods Thirty-fve patients submitted to sleeve gastrectomy were evaluated, 29 of whom were female (82.9%), with a mean age of 35.2 years and an average body mass index of 38.1 kg/m2 . Endoscopic samples of the mucosa were collected, whose ghrelin expression was evaluated in a semi-quantitative way through the stained antibody area. These data were correlated with weight loss at 3, 6, and 12 months and with the control of comorbidities, and infammatory alterations. Results The average total weight loss (TWL%) was 17.7, 26.4, and 32.1%, respectively, at 3, 6, and 12 months. A negative correlation was found between the immunohistochemical expression of ghrelin in the endoscopic biopsy of the fundus and weight loss at 3 (s= −0.536; p=0.001) and 6 months (s= −0.339; p=0.047). Conclusion The immunohistochemical expression of ghrelin in the mucosa of the gastric fundus was negatively correlated with early weight loss after sleeve gastrectomy
Tratamento de fístulas enterocutâneas através de sistema a vácuo com alta pressão e dieta oral normal
(Universidade Federal do Rio Grande do Norte, 2005-04-12) Aires Neto, Tertuliano; ; http://lattes.cnpq.br/9873289951810864; ; http://lattes.cnpq.br/7847977596554977; Brandt, Carlos Teixeira; ; http://lattes.cnpq.br/4540675807816003; Rezende, Adriana Augusto de; ; http://lattes.cnpq.br/4245215108740331; Schwarzschild, Lúcia de Fátima Campos Pedrosa; ; http://lattes.cnpq.br/1863589790139155; Goldenberg, Alberto; ; http://lattes.cnpq.br/9234173201339052
As fístulas enterocutâneas são associadas com hospitalização prolongada, alta morbidez e mortalidade, e aumento dos custos hospitalares. Foi realizado estudo com o objetivo de analisar o uso de um sistema a vácuo e dieta oral normal para o tratamento dessas fístulas. Métodos: Foram analisados setenta e quatro pacientes consecutivos portadores de fístulas enterocutâneas pós-operatórias, recentes e bem definidas. Exames abdominais por imagem foram usados para excluir abscesso e obstrução intestinal distal. O trajeto fistuloso foi fechado com sonda de Foley conectada a um frasco de pressão negativa, que era trocado diariamente por 5, 10 ou 15 dias, conforme necessário. Foi permitida dieta oral normal a todos os pacientes. Resultados: Nenhum paciente morreu. Os níveis de albumina e transferrina sérica mostraram-se significativamente mais elevados no final do tratamento, quanto comparado com seu início. As fstulas de débitos baixo e moderado atingiram os melhores resultados e 97% delas fecharam. Quarenta e oito (65%) fístulas fecharam após 5 dias, 16(22%) após 10 dias e 4(5%) após 15 dias de tratamento. O sistema falhou em 6(8%) pacientes, que subseqüentemente foram submetidos a intervenção cirúrgica. Apenas em um paciente com fiístula de baixo débito não se conseguiu resultado satisfatório. O tratamento teve o custo diário de R$ 108,55 e foi considerado baixo e efetivo. Conclusões: O sistema a vácuo utilizado demonstrou bons resultados no tratamento das fístulas. Caracterizou-se por simplicidade na execução, baixo custo, curto período de hospitalização, ausência de lesões cutâneas, dieta normal, bom estado nutricional, mobilidade e atividades normais dos pacientes

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Navegando por Autor "Goldenberg, Alberto"