Navegando por Autor "Gomes-Leal, Walace"
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Artigo Copaiba Oil-Resin Treatment Is Neuroprotective and Reduces Neutrophil Recruitment andMicroglia Activation after Motor Cortex Excitotoxic Injury(2012-11-16) Guimarães-Santos, Adriano; Santos, Diego Siqueira; Santos, Ijair Rogério; Lima, Rafael Rodrigues; Pereira, Antonio; Moura, Lucinewton Silva de; Carvalho Jr., Raul Nunes; Lameira, Osmar; Gomes-Leal, WalaceThe oil-resin of Copaifera reticulata Ducke is used in the Brazilian folk medicine as an anti-inflammatory and healing agent. However, there are no investigations on the possible anti-inflammatory and neuroprotective roles of copaiba oil-resin (COR) after neural disorders.We have investigated the anti-inflammatory and neuroprotective effects of COR following an acute damage to the motor cortex of adult rats. Animals were injected with the neurotoxin N-Methyl-D-Aspartate (NMDA) (n = 10) and treated with a single dose of COR (400 mg/kg, i.p.) soon after surgery (Group 1) or with two daily doses (200 mg/kg, i.p.) during 3 days (Group 2) alter injury. Control animals were treated with vehicle only. COR treatment induced tissue preservation and decreased the recruitment of neutrophils and microglial activation in the injury site compared to vehicle animals. The results suggest that COR treatment induces neuroprotection by modulating inflammatory response following an acute damage to the central nervous system.Artigo Minocycline treatment reduces white matter damage after excitotoxic striatal injury(2010) Guimarães, Joanilson S.; Freire, Marco Aurelio M.; Lima, Rafael R.; Picanço-Diniz, Cristovam W.; Pereira, Antonio; Gomes-Leal, WalaceWe investigated the protective effects of minocycline following white matter damage (WMD) in the rat striatum. Excitotoxic lesions were induced by N-Methyl-D-Aspartate (NMDA) microinjections and caused striatal damage, concomitant with microglial/ macrophage activation. The excitotoxic lesion both damaged oligodendrocytes (Tau-1+ cells) and caused a decrease in tissue reactivity for myelin basic protein (MBP) after postlesional day 3 (PLD). Treatment with the semi-synthetic tetracycline antibiotic minocycline, however, led to oligodendrocyte preservation and decreased myelin impairment. Taken together, these results suggest that white matter damage (WMD) is an important component of the physiopathology of acute striatal damage and that microglial/ macrophage activation contributes to this pathological phenomenon.