Navegando por Autor "Hirata, Rosario Dominguez Crespo"
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Artigo Association of serum alpha-tocopherol and retinol with the extent of coronary lesions in coronary artery disease(Journal of Nutrition and Metabolism, 2018-12-11) Ribeiro, Karla Danielly da Silva; Miranda, Carolinne Thaísa de Oliveira Fernandes; Duarte, Victor Hugo Rezende; Cruz, Marina Sampaio de Menezes; Duarte, Mychelle Kytchia Rodrigues Nunes; Araújo, Jéssica Nayara Góes de; Santos, Ayda Maria Quirino Silva dos; Oliveira, Juliana Marinho de; Paiva, Maria Sanali Moura Oliveira; Rezende, Adriana Augusto; Hirata, Mario Hiroyuki; Hirata, Rosario Dominguez Crespo; Luchessi, André Ducati; Silbiger, Vivian Nogueira; https://orcid.org/0000-0001-7708-4271; https://orcid.org/0000-0003-3073-5967; https://orcid.org/0000-0002-9252-0278; https://orcid.org/0000-0002-2251-5967; https://orcid.org/0000-0002-3122-9073; https://orcid.org/0000-0002-2276-690X; https://orcid.org/0000-0003-2452-4047; https://orcid.org/0000-0002-9521-7979; https://orcid.org/0000-0002-2758-8102Background and aims: Fat-soluble vitamins play an important role in the pathogenesis of cardiovascular disease and progression ofatherosclerosis. +is study aimed at investigating the relationship of the serum levels of alpha-tocopherol and retinol with theextent of coronary lesions in patients with coronary artery disease. Methods. Patients with coronary artery disease (n = 177) aged 30 – 74 years, who underwent their first coronary angiography, were enrolled. The extent of coronary lesions was assessed using th eFriesinger index (FI). Accordingly, patients were grouped as follows: FI = 0–4 (n = 90), FI = 5–9 (n = 50), and FI = 10–15 (n = 37).Serum levels of vitamins were determined via high-performance liquid chromatography and serum biochemical analysis. Results.Assessment of FI-based groups revealed that 50.8% patients had a coronary artery lesion to a low extent (FI 0–4). Individuals inthis group were younger and had lower glucose and serum alpha-tocopherol levels than the other groups (p < 0.05). Low levels of alpha-tocopherol were more frequent in the FI 0–4 group than that in the other groups (p = 0.03). No difference was observedbetween the mean serum retinol levels among the FI-based groups (n = 0.492), and the low frequency of retinol was consistentamong the FI groups (n = 0.348). Conclusions. The low level of alpha-tocopherol together with the presence of dyslipidemia isprobably associated with the initial events in atherosclerosis. Increased alpha-tocopherol levels in patients with more extensivecoronary artery lesions may have resulted from altered vitamin E metabolism with increased oxidative stress.Artigo The let-7b-5p, miR-326, and miR-125a-3p are associated with left ventricular systolic dysfunction in post-myocardial infarction(Frontiers in Cardiovascular Medicine, 2023-05) Reis, Bruna Zavarize; Komatsu, Raquel Costa Silva Dantas; Cruz, Marina Sampaio; Freire, Paula Paccielli; Diniz, Rosiane Viana Zuza; Bortolin, Raul Hernandes; Marques, Otávio Cabral; Souza, Kamilla Batista da Silva; Hirata, Mario Hiroyuki; Hirata, Rosario Dominguez Crespo; Jurisica, Igor; Silbiger, Vivian Nogueira; Luchessi, André DucatiBackground: Acute ST-elevation myocardial infarction (STEMI) can lead to adverse cardiac remodeling, resulting in left ventricular systolic dysfunction (LVSd) and heart failure. Epigenetic regulators, such as microRNAs, may be involved in the physiopathology of LVSd. Objective: This study explored microRNAs in peripheral blood mononuclear cells (PBMC) of post-myocardial infarction patients with LVSd. Methods: Post-STEMI patients were grouped as having (LVSd, n = 9) or not LVSd (non-LVSd, n = 16). The expression of 61 microRNAs was analyzed in PBMC by RT-qPCR and the differentially expressed microRNAs were identified. Principal Component Analysis stratified the microRNAs based on the development of dysfunction. Predictive variables of LVSd were investigated through logistic regression analysis. A system biology approach was used to explore the regulatory molecular network of the disease and an enrichment analysis was performed. Results: The let-7b-5p (AUC: 0.807; 95% CI: 0.63–0.98; p = 0.013), miR-125a-3p (AUC: 0.800; 95% CI: 0.61–0.99; p = 0.036) and miR-326 (AUC: 0.783; 95% CI: 0.54–1.00; p = 0.028) were upregulated in LVSd ( p < 0.05) and discriminated LVSd from non-LVSd. Multivariate logistic regression analysis showed let-7b-5p (OR: 16.00; 95% CI: 1.54–166.05; p = 0.020) and miR-326 (OR: 28.00; 95% CI: 2.42–323.70; p = 0.008) as predictors of LVSd. The enrichment analysis revealed association of the targets of these three microRNAs with immunological response, cell-cell adhesion, and cardiac changes. Conclusion: LVSd alters the expression of let-7b-5p, miR-326, and miR-125a-3p in PBMC from post-STEMI, indicating their potential involvement in the cardiac dysfunction physiopathology and highlighting these miRNAs as possible LVSd biomarkers