Navegando por Autor "Idalina Neta, Francisca"
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Artigo Effects of Mucuna pruriens (L.) supplementation on experimental models of parkinson's disease: a systematic review(Medknow Publications, 2018) Idalina Neta, Francisca; Costa, Ianara Mendonça da; Lima, Francisca Overlânia Vieira; Fernandes, Luciana Cristina Borges; Cavalcanti, José Rodolfo Lopes de Paiva; Freire, Marco Aurélio de Moura; Lucena, Eudes Euler De Souza; Rêgo, Amália Cinthia Meneses do; Araújo Filho, Irami; Azevedo, Eduardo Pereira de; Guzen, Fausto PierdonáIntroduction: Mucuna pruriens (L.)DC. (Mp) has been used in the treatment of numerous diseases in Indian Ayurvedic medicine, mainly for delaying the symptoms of Parkinson’s disease (PD), and has as its main component levodopa (L‑DOPA). The aim of this work is to systematically review the effects of Mp supplementation on experimental models of PD due to its neuroprotective and antioxidant properties. MATERIALS AND Methods: The search was conducted through PubMed, ScienceDirect, Cochrane Library, and Scientific Electronic Library Online databases, where a number of relevant articles were found. Results: Mp demonstrated significant positive responses in the experimental models of PD by improving motor deficits and by enhancing the activity of the antioxidant systems, reducing oxidative stress. In addition, it presented some advantages when compared to a conventional antiparkinsonian drug as it minimized the occurrence and severity of dyskinesias. Conclusion: Thus, considering that the use of herbal medicines decreases the likelihood of side effects associated with the pharmaceutical drugs, this work aims to summarize and evaluate the data available regarding the mechanism of action of Mp and the reported benefits of this plant as an alternative to improve the quality of life of individuals with PDArtigo Effects of supplementation with probiotics in experimental models of alzheimer's disease: a systematic review of animal experiments(Bentham Science Publishers, 2022-04-06) Idalina Neta, Francisca; Souza, Francisco Emílio Simplício de; Batista, André Lima; Pinheiro, Francisco Irochima; Cobucci, Ricardo Ney; Guzen, Fausto PierdonáBackground: Conditions along the brain-gut-microbiota (BGM) axis can significantly contribute to the pathogenesis of Alzheimer's disease (AD). Evidence from animal studies indicates a role of probiotics in regulating mood, cognition, and stress response via the BGM axis. However, the effect of probiotics on AD needs to be better clarified in preclinical and clinical studies. Methods : We prepared this systematic review according to PRISMA. PubMed, Web of Science, Embase, and Virtual Health Library (VHL) were searched for original articles concerning the effects of probiotics in experimental AD. Results: Results were presented as a narrative synthesis according to the Synthesis Without Metaanalysis (SWiM) Guideline. Seventeen studies met the inclusion criteria. The results showed significant effects in the experimental models of AD treated with probiotics alone or in mixture due to expressive improvements in cognitive tests. Conclusion: Furthermore, in most of the included studies, it was possible to observe a reduction in inflammatory processes, an increase in the concentration of peptide hormones, insulin homeostasis in the brain, increased antioxidant enzymes, and a decrease in beta-amyloid deposition and tau hyperphosphorylation. Supplementation of probiotics seems to improve performance in cognitive tests and increase the concentration of substances capable of delaying the neurodegenerative process of AD in experimental models.