Navegando por Autor "Jeronimo, Selma M. B."
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Artigo Egos has a reduced capacity to predicts GBS prognosis in Northeast Brazil(Wiley, 2018) Dourado Junior, Mário Emílio Teixeira; Fernandes, Ugor T.; Ramos, Eugênio S.; Vital, Ana L. F.; Urbano, João C. C.; Queiroz, José W.; Jeronimo, Selma M. B.; https://orcid.org/0000-0002-9462-2294Objective: The Erasmus Guillain Barre Outcome Score (EGOS) is a prognostic model that predicts the chance of being able to walk independently at 6 months after Guillain Barré syndrome (GBS). This study was conducted aiming to determine the validity of EGOS in a Brazilian population.Material and Methods: Data collected from GBS patients in Rio Grande do Norte, Brazil, were used to determine the validity of EGOS. GBS disability score was as-sessed in the second week of disease and at 6 months.Results: A total of 206 subjects were studied. The Brazilian patients were younger, with a more severe clinical presentation, with higher percentage of cranial nerve in-volvement and upper respiratory infection. There was no difference relative to sex or presence of anti- gangliosides antibodies. The demyelinating variant was more com-mon (73.9%). However, only 24% of the Brazilians with EGOS 5.5-7 were not able to walk after 6 months, compared to 52% to European Group. Nine patients (3.8%) pre-sented nodopathies, of these four had an EGOS >5, but only one of the latter group was unable to walk after 6 months of GBS.Conclusions: Erasmus Guillain Barre Outcome Score was not a good predictor for the ability to walk after 6 months of GBS in Rio Grande do Norte, Brazil. Differences could be that the Brazilian GBS were younger, or alternatively, it could be due to a different infection profile or in the incidence of nodopathies.Artigo Transcriptional Changes That Characterize the Immune Reactions of Leprosy(Universidade Federal do Rio Grande do Norte, 2014) Dupnik, Kathryn M.; Bair, Thomas B.; Maia, Andressa O.; Amorim, Francianne M.; Costa, Marcos Romualdo; Keesen, Tatjana S. L.; Valverde, Joanna G.; Queiroz, Maria do Carmo A. P.; Medeiros, Lúcio L.; Lucena, Nelly L. de; Wilson, Mary E.; Nobre, Mauricio L.; Johnson Jr, Warren D.; Jeronimo, Selma M. B.Background: Leprosy morbidity is increased by 2 pathologic immune reactions, reversal reaction (RR) and erythema nodosum leprosum (ENL). Methods: To discover host factors related to immune reactions, global transcriptional profiles of peripheral blood mononuclear cells were compared between 11 RR, 11 ENL, and 19 matched control patients, with confirmation by quantitative polymerase chain reaction. Encoded proteins were investigated in skin biopsy specimens by means of immunohistochemistry. Results: There were 275 genes differentially expressed in RR and 517 differentially expressed in ENL on the microarray. Pathway analysis showed immunity-related pathways represented in RR and ENL transcriptional profiles, with the “complement and coagulation” pathway common to both. Interferon γ was identified as a significant upstream regulator of the expression changes for RR and ENL. Immunohistochemical staining of skin lesions showed increased C1q in both RR and ENL. Conclusions: These data suggest a previously underrecognized role for complement in the pathogenesis of both RR and ENL, and we propose new hypotheses for reaction pathogenesis.