Navegando por Autor "Kühl, Andre"
Agora exibindo 1 - 1 de 1
- Resultados por página
- Opções de Ordenação
Artigo PAI-1 expression in intratumoral inflammatory infiltrate contributes to lymph node metastasis in oral cancer: a cross-sectional study(Elsevier, 2021-04-15) Oliveira, Mayara Mota de; Peterle, Gabriela Tonini; Couto, Cinthia Vidal Monteiro da Silva; Maia, Lucas de Lima; Kühl, Andre; Santos, Joaquim Gasparini dos; Moysés, Raquel Ajub; Trivilin, Leonardo Oliveira; Borçoi, Aline Ribeiro; Archanjo, Anderson Barros; Assis, Arícia Leone Evangelista Monteiro de; Nunes, Fábio Daumas; Santos, Marcelo dos; Silva, Adriana Madeira Álvares daIntroduction: Immune cells contribute with mediators in the protein expression profile of the tumor microenvi ronment. Levels of plasminogen activator inhibitor-1 (PAI-1) are elevated in non-malignant inflammatory con ditions; however, the association between PAI-1 expression and inflammation remains uncertain in oral squamous cell carcinoma (OSCC). This study aimed to investigate PAI-1 expression in mononuclear inflammatory cell infiltrate in OSCC and its role as a prognostic marker. Methods: Samples were collected from patients with OSCC, treated surgically, and followed for 24 months after the procedure. Thirty-nine tumoral tissue were analyzed using immunohistochemistry. Correlation between protein expression, clinicopathological parameters, and the prognosis was investigated. Results: Positive PAI-1 expression in mononuclear inflammatory cell infiltrate was significantly associated with lymph node status (p = 0.009) and with the cytoplasmic expression of vascular endothelial growth factor A (VEGFA) (p = 0.028). Multivariate analysis revealed weak PAI-1 expression as an independent marker for lymph node metastases, with approximately 8-fold increased risk compared to strong expression (OR = 8.60; CI =1.54–48.08; p = 0.014). Conclusion: Our results suggest that the strong PAI-1 expression in intratumoral inflammatory infiltrate is an indicator of a better prognosis for patients diagnosed with oral squamous cell carcinoma.