Navegando por Autor "Lima, Vanessa C. O. de"
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Artigo Tamarind (Tamarindus indica L.) seed a candidate protein source with potential for combating SARS-CoV-2 infection in obesity(Drug Target Insights, 2021) Morais, Ana Heloneida de Araújo; Medeiros, Amanda F. de; Medeiros, Isaiane; Lima, Vanessa C. O. de; Luz, Anna B. S.; Maciel, Bruna L. L.; Passos, Thaís S.; https://orcid.org/0000-0002-6460-911XIntroduction: Obesity and coronavirus disease (COVID)-19 are overlapping pandemics, and one might worsen the other. Methods: This narrative review discusses one of the primary mechanisms to initiate acute respiratory distress syndrome, uncontrolled systemic inflammation in COVID-19, and presents a potential candidate for adjuvant treatment. Blocking the S protein binding to angiotensin-converting enzyme 2 (ACE-2) and the 3C-like protease (3CL pro) is an effective strategy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Results: Host proteases such as FURIN, trypsin, and transmembrane serine protease 2 (TMPRSS) act in S protein activation. Tamarind trypsin inhibitor (TTI) shows several beneficial effects on the reduction of inflammatory markers (tumor necrosis factor α [TNF-α], leptin) and biochemical parameters (fasting glycemia, triglycerides, and very low-density lipoprotein [VLDL]), in addition to improving pancreatic function and mucosal integrity in an obesity model. TTI may inhibit the action of proteases that collaborate with SARS-CoV-2 infection and the neutro phil activity characteristic of lung injury promoted by the virus. Conclusion: Thus, TTI may contribute to combating two severe overlapping problems with high cost and social complex implications, obesity and COVID-19.