Navegando por Autor "Marcadenti, Aline"
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Artigo Effects of a Brazilian cardioprotective diet and nuts on cardiometabolic parameters after myocardial infarction: study protocol for a randomized controlled clinical trial(Trials, 2021-09) Fayh, Ana Paula Trussardi; Bezerra, Danielle Soares; Marcadenti, Aline; Weber, Bernardete; Bersch-Ferreira, Angela Cristine; Machado, Rachel Helena Vieira; Torreglosa, Camila Ragne; Lara, Enilda Maria de Sousa; Silva, Lucas Ribeiro da; Santos, Renato Hideo Nakagawa; Myada, Debora Harumi Kodama; Sady, Erica Regina Ribeiro; Costa, Rosana Perim; Piegas, Leopoldo; Silva, Erlon Oliveira de Abreu; Quadros, Alexandre Schaan de; Weschenfelder, Camila; Santos, Júlia Lorenzon dos; Souza, Gabriela Corrêa; Parahiba, Suena Medeiros; Carvalho, Ana Paula Perillo Ferreira; Machado, Malaine Morais Alves; Vasconcelos, Sandra Mary Lima; Araújo, Jéssika; Figueiredo Neto, José Albuquerque de; Dias, Luciana Pereira Pinto; Nagano, Francisca Eugenia Zaina; Almeida, Cássia Cristina Paes de; Moreira, Annie Seixas Bello; Gapanowicz, Débora Pinto; Purgatto, Eduardo; Rogero, Marcelo Macedo; Sampaio, Geni Rodrigues; Torres, Elizabeth Aparecida Ferraz da Silva; Duarte, Graziela Biude Silva; Cavalcanti, Alexandre BiasiBackground: Nut consumption has been related to improvements on cardiometabolic parameters and reduction in the severity of atherosclerosis mainly in primary cardiovascular prevention. The objective of this trial is to evaluate the effects of the Brazilian Cardioprotective Diet (DIeta CArdioprotetora Brasileira, DICA Br) based on consumption of inexpensive locally accessible foods supplemented or not with mixed nuts on cardiometabolic features in patients with previous myocardial infarction (MI)Artigo Is cachexia associated with chemotherapy toxicities in gastrointestinal cancer patients? a prospective study(Journal of Cachexia, Sarcopenia and Muscle, 2019-03) Fayh, Ana Paula Trussardi; Rocha, Ilanna Marques Gomes da; Marcadenti, Aline; Medeiros, Galtieri Otávio Cunha de; Bezerra, Ricardo Andrade; Rego, Juliana Florinda de Mendonça; Gonzalez, Maria CristinaBackgroundChemotherapy is an effective treatment with good clinical response in patients with cancer. However, it cancause exacerbated toxicities in patients and consequently change the course of treatment. Some factors may interfere withthis toxicity such as body composition, especially in gastrointestinal cancer. The aim of this study was to evaluate the effectsof body composition, nutritional status, and functional capacity scale in predicting the occurrence of toxicities in gastrointes-tinal cancer patients during chemotherapy treatment.MethodsThis is a prospective study with gastrointestinal cancer patients at the beginning of chemotherapy treatment.Sarcopenia and muscle attenuation were assessed using the skeletal muscle index from computerized tomography by measur-ing cross-sectional areas of the L3tissue (cm2/m2). Cachexia was graded according to involuntary weight loss associated withsarcopenia. Nutritional status was assessed by using anthropometric evaluation and Patient-Generated Subjective Global As-sessment. Functional capacity was evaluated by handgrip strength and Eastern Cooperative Oncology Group (ECOG) Perfor-mance Status scale. Haematological gastrointestinal and dose-limiting toxicities (DLTs) were defined according to NationalCancer Institute Common Toxicity Criteria. The associations among sarcopenia, cachexia, nutritional status, and functional ca-pacity with DLT were assessed by univariate and multivariate Cox regression model.ResultsA total of60patients were evaluated (55% male,60.9±14.0years) and followed up for a mean of55days. Mostpatients had normal weight (44.2%) and good ECOG Performance Status (≤1) at baseline (78%). During the chemotherapy pe-riod, the most prevalent toxicities were diarrhoea, nausea, and anorexia, but the presence of DLT was similar between cycles(P>0.05). Cachexia was associated with a higher toxicity manifested by diarrhoea (P=0.02), nausea (P=0.02), and anorexia(P<0.01andP=0.03at Cycles1and2, respectively). Sarcopenic and cachetic individuals experienced more toxicities and DLTduring chemotherapy. The only factors associated with DLT in the multivariate Cox regression analyses including the presenceof metastasis and the chemotherapy protocol were cachexia and the ECOG scale (P<0.001for both).ConclusionsCachexia and ECOG score may identify patients with an increased risk for developing severe toxicity events dur-ing chemotherapy treatment for gastrointestinal cancerArtigo Nutritional status and appetite-regulating hormones in early treatment of acute lymphoblastic leukemia among children and adolescents: a cohort study(Sao Paulo Medical Journal, 2020) Fayh, Ana Paula Trussardi; Gomes, Camila de Carvalho; Silva, Cassia Camila Gomes da; Nascimento, Paulo Ricardo Porfírio do; Lemos, Telma Maria de Araújo Moura; Marcadenti, Aline; Markoski, Melissa MedeirosBACKGROUND: Children with acute lymphoblastic leukemia are at risk of malnutrition, but few studies have described the changes in nutritional status during the different phases of chemotherapy. OBJECTIVE: To evaluate changes in nutritional status, food intake and appetite-regulating hormones among children and adolescents with acute lymphoblastic leukemia in the first phase of chemotherapy. DESIGN AND SETTING: Cohort study developed in the pediatric oncology departments of two hospitals in the city of Natal, Rio Grande do Norte, Brazil. METHODS: Fourteen children/adolescents (mean age of 7 years; 50% female) with acute lymphoblastic leukemia were monitored over the 28 days of an induction chemotherapy cycle. Anthropometric measurements, 24-hours food weight records and appetite-regulating hormone levels (ghrelin, leptin, insulin and cortisol) were obtained at three different times (before, in the middle and at the end of the induction phase). RESULTS: Most of the patients (85.7%) had normal weight at the beginning of the treatment, and this did not change significantly during the 28 days. Energy and nutrient intakes improved from the start of the treatment to the midpoint, according to the ghrelin levels (from 511.1 ± 8.3 to 519.3 ± 6.6 pg/ml; P = 0.027). Other appetite-regulating hormones did not present changes. CONCLUSION: Food consumption improves during the first phase of treatment, without alterations in anthropometric nutritional statusArtigo The effect of carbohydrate mouth rinse on performance, biochemical and psychophysiological variables during a cycling time trial: a crossover randomized trial(Journal of the International Society of Sports Nutrition, 2018-05) Fayh, Ana Paula Trussardi; Ferreira, Amanda Maria de Jesus; Farias Junior, Luiz Fernando; Mota, Thaynan Aline de Araújo; Elsangedy, Hassan Mohamed; Marcadenti, Aline; Lemos, Telma Maria de Araújo Moura; Okano, Alexandre HidekiBackground: The hypothesis of the central effect of carbohydrate mouth rinse (CMR) on performance improvement in a fed state has not been established, and its psychophysiological responses have not yet been described. The aim of this study was to evaluate the effect of CMR in athletes fed state on performance, biochemical and psychophysiological responses compared to ad libitum water intake. Methods: Eleven trained male cyclists completed a randomized, crossover trial, which consisted of a 30 km cycle ergometer at self-selected intensity and in a fed state. Subjects were under random influence of the following interventions: CMR with a 6% unflavored maltodextrin solution; mouth rinsing with a placebo solution (PMR); drinking “ad libitum” (DAL). The time for completion of the test (min), heart rate (bpm) and power (watts), rating of perceived exertion (RPE), affective response, blood glucose (mg/dL) and lactate (mmol/DL), were evaluated before, during and immediately after the test, while insulin (uIL/mL), cortisol (μg/dL) and creatine kinase (U/L) levels were measured before, immediately after the test and 30 min after the test. Results: Time for completion of the 30 km trial did not differ significantly among CMR, PMR and DAL interventions (means = 54.5 ± 2.9, 54.7 ± 2.9 and 54.5 ± 2.5 min, respectively; p = 0.82). RPE and affective response were higher in DAL intervention (p < 0.01). Glucose, insulin, cortisol and creatine kinase responses showed no significant difference among interventions. Conclusions: In a fed state, CMR has not caused metabolic changes, and it has not improved physical performance compared to ad libitum water intake, but demonstrated a possible central effect. ReBec registration number: RBR4vpwkg. Available in http://www.ensaiosclinicos.gov.br/rg/?q=RBR-4vpwkg