Navegando por Autor "Medeiros, Aldo C."

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Design of Magnetic Polymeric Particles as a Stimulus-Responsive System for Gastric Antimicrobial Therapy
(Springer Nature Switzerland AG, 2016-12-13) Carriço, Artur da Silva; Silva-Freitas, Erica L.; Pontes, Thales R. F.; Araújo-Neto, Rafael P.; Damasceno, Ítalo H. M.; Silva, Kátia L.; Carvalho, Juliana F.; Medeiros, Aldo C.; Silva, Rodolfo B.; Silva, Amanda K. A.; Morales, Marco A.; Egito, Eryvaldo S. T.; Dantas, Ana L.
The treatment of peptic ulcers induced by H. pylori remains challenging due to the deep mucous layer location of bacteria preventing antimicrobial drug access. The present work aimed to design and evaluate in vitro dual responsive (both pH and magnetic field-sensitive) polymeric magnetic particles loaded with amoxicillin as a smart drug carrier for deep mucous layer penetration and in situ drug release. Magnetite particles were produced by the co-precipitation method and subsequently coated with the Eudragit®S100 and amoxicillin by using the spray-drying technique. The physicochemical characterization of the obtained particles was carried out by optical and scanning electron microscopy, X-ray powder diffraction, Fourier transform infrared spectroscopy, nitrogen adsorption/desorption isotherms, and vibrating sample magnetometry. Additionally, drug release tests and antibacterial activity tests were evaluated in vitro. Microparticles presented 17.2 ± 0.4 μm in size and their final composition was 4.3 ± 1.5% of amoxicillin, 87.0 ± 2.3% of Eudragit, and 9.0 ± 0.3% of magnetite. They were both pH and magnetic field responsive while presenting antimicrobial activity. On one side, magnetic field responsiveness of particles is expected to prompt them to reach bacterium niche in deep mucous layer by means of magnetic forces. On the other side, pH responsiveness is expected to enable drug release in the neutral pH of the deep mucous layer, preventing undesired delivery in the acidic gastric lumen. Smart microparticles were designed presenting both pH and magnetic field responsiveness as well as antimicrobial activity. These may be promising assets for peptic ulcer treatment.
Synthesis and characterization of xylan-coated magnetite microparticles
(International Journal of Pharmaceutics, 2006-10-13) Araújo, Jose Humberto de; Silva, Amanda Karina Andriola; Silva, Érica L. da; Oliveira, Elquio Eleamen; Soares, Luiz Alberto Lira; Nagashima Junior, Toshiyuiky; Medeiros, Aldo C.; Araújo, Ivonete Batista de; Carriço, Artur Silva; Egito, Eryvaldo Sócrates Tabosa do
This work evaluates an experimental set-up to coat superparamagnetic particles in order to protect them from gastric dissolution. First, magnetic particles were produced by coprecipitation of iron salts in alkaline medium. Afterwards, an emulsification/cross-linking reaction was carried out in order to produce magnetic polymeric particles. The sample characterization was performed by X-ray powder diffraction, laser scattering particle size analysis, optical microscopy, thermogravimetric analysis and vibrating sample magnetometry. In vitro dissolution tests at gastric pH were evaluated for both magnetic particles and magnetic polymeric particles. The characterization data have demonstrated the feasibility of the presented method to coat, and protect magnetite particles from gastric dissolution. Such systems may be very promising for oral administration

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Navegando por Autor "Medeiros, Aldo C."