Navegando por Autor "Mendes, Suzanny Oliveira"

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Alcoolismo, tabagismo e exposição aos agrotóxicos: avaliação epidemiológica e molecular como auxiliar na prevenção e questões de saúde
(ESCS - Escola Superior de Ciências da Saúde, 2018-02) Archanjo, Anderson Barros; Borçoi, Aline Ribeiro; Assis, Arícia Leone Evangelista Monteiro de; David, Camila Vieira Chagas; Almança, Carlos Cesar Jorden; Conti, Catarine; Couto, Cinthia Vidal Monteiro da Silva; Camuzi, Diego; Freitas, Érika Aparecida Silva de; Cunha, Ester Ribeiro; Freitas, Flávia Vitorino; Guanaes, Gabriel Madeira da Silva; Peterle, Gabriela Tonini; Robe, Gabrielly Assis; Valiate, Guilherme Colli; Simão, João Batista Pavesi; Santos, Joaquim Gasparini; Pinheiro, Julia de Assis; Dalbó, Juliana; Arpini, Juliana Krüger; Brito, Larissa Bettcher; Trivilin, Leonardo Oliveira; Romão, Letícia Parmanhani; Maia, Lucas de Lima; Santos, Marcelo dos; Vianna, Márcio Vinicius Moreira; Oliveira, Mayara Mota de; Miranda, Maycown Douglas de Oliveira; Reis, Schalana de Oliveira; Mendes, Suzanny Oliveira; Barbosa, Wagner Miranda; Gai, Zélia Terezinha; Hemerly, Jefferson Pessoa; Zago, Hugo Bolsoni; Ventura, José Aires; Louro, Iuri Drummond; Nunes, Fabio Daumas; Silva, Eloiza Helena Tajara da; Rocha, José Cláudio Casali da; Álvares‑da‑Silva, Adriana Madeira
Objetivos: Realizar medidas de educação visando a prevenção em saúde e melhor qualidade de vida, e obter dados através de levantamento epidemiológico que poderão ser fornecidos ao SUS como um modelo de região rural que poderá ser utilizado em outras regiões do país gerando um grande impacto social e economia de recursos federais, estaduais e municipais. Resultados: Juntamente com os questionários e visitas às comunidades estudadas, foram realizadas ações educativas para a prevenção do uso indiscriminado de agrotóxicos, assim como o uso de tabaco e álcool. Vale apena destacar a parceria com diversos outros projetos na região, que possibilitou a oferta de cursos de capacitação EAD e presenciais, assim como a elaboração de material didático sobre o assunto na forma de livros, aulas e or‑ganização de espaços virtuais de aprendizagem e de treinamento. Conclusão: O projeto gerou impacto social, com treinamento de professores e crianças nas escolas, além dos agentes de saúde e outros profissionais que atuam na saúde e educação dentro dos municípios. Finalmente, um ponto de grande destaque relacionado às metas do projeto foi a capacitação e formação de pessoas na área de oncogenética e aconselhamento genético, algo inédito para o estado do Espírito Santo
Carcinoma de células escamosas da cavidade oral: associação do hábito tabagista nas concentrações dos elementos químicos
(Atena Editora, 2020) Archanjo, Anderson Barros; Assis, Arícia Leone Evangelista Monteiro de; Oliveira, Mayara Mota de; Mendes, Suzanny Oliveira; Borçoi, Aline Ribeiro; Souza, Rafael Pereira de; Cicco, Rafael de; Trivilin, Leonardo Oliveira; Pinheiro, Christiano Jorge Gomes; Santos, Marcelo dos; Nogueira, Breno Valentim; Silva, Adriana Madeira Álvares da
O câncer de cabeça e pescoço é altamente maligno, agressivo e com elevada taxa de morbidade e mortalidade. Apresenta etiologia complexa e multifatorial, sendo o consumo de tabaco e álcool os principais. A fumaça do tabaco leva ao organismos inúmeros elementos traço e estes são relacionadas com a carcinogênese, no entanto poucos estudo apontam o papel de tais elementos no prognóstico e na sobrevida. Assim, objetivou-se avaliar a relação dos níveis elementares de enxofre, cloro, cobre, zinco e bromo com o tabagismo, prognóstico e sobrevida de pacientes com câncer oral. Para isto, foram obtidas 78 amostras carcinoma de células escamosas da cavidade oral para a determinação dos níveis S, Cl, Cu, Zn e Br utilizando a técnica de µ-XRF. Os resultados revelaram uma associação da concentração dos elementos S, Cl, Cu e Br com o hábito tabagista. Os níveis altos de cobre e zinco foram associados a recidiva, contudo o cobre a uma melhor sobrevida livre de doença e o zinco a uma pior sobrevida doença específica. Assim, conclui-se que a investigação dos níveis de enxofre, cloro, cobre, zinco e bromo é importante para auxiliar na elucidação dos mecanismos envolvidos na progressão tumoral e na sobrevida. Além disto, cobre e zinco se mostraram importantes marcadores prognóstico e de sobrevida para pacientes com câncer oral.
Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival
(Nature Research, 2020-06-25) Archanjo, Anderson Barros; Assis, Arícia Leone Evangelista Monteiro de; Oliveira, Mayara Mota de; Mendes, Suzanny Oliveira; Borçoi, Aline Ribeiro; Maia, Lucas de Lima; Souza, Rafael Pereira de; Cicco, Rafael de; Saito, Kelly Cristina; Kimura, Edna Teruko; Carvalho, Marcos Brasilino de; Nunes, Fabio Daumas; Tajara, Eloiza H.; Santos, Marcelo dos; Nogueira, Breno Valentim; Trivilin, Leonardo Oliveira; Pinheiro, Christiano Jorge Gomes; Silva, Adriana Madeira Álvares da
Oral cancer squamous cell carcinoma (OCSCC) mainly affects individuals aged between 50 and 70 years who consume tobacco and alcohol. Tobacco smoke contains hundreds of known toxic and carcinogenic molecules, and a few studies have sought to verify the relationship of such trace elements as risk or prognostic factors for head and neck cancer. We obtained 78 samples of tumor tissues from patients with OCSCC, and performed a qualitative elemental characterization using the micro X-Ray Fluorescence technique based on synchrotron radiation. We found the presence of magnesium, phosphorus, sulfur, chlorine, potassium, calcium, chromium, manganese, iron, zinc, cobalt, nickel, copper, arsenic and bromine in OCSCC samples. Magnesium, chlorine, chromium, manganese, nickel, arsenic and bromine are associated with smoking. We observed a significant association between relapse and chlorine and chromium. The presence of chlorine in the samples was an independent protective factor against relapse (OR = 0.105, CI = 0.01–0.63) and for best disease-free survival (HR = 0.194, CI = 0.04–0.87). Reporting for the first time in oral cancer, these results suggest a key relationship between smoking and the presence of certain elements. In addition, chlorine proved to be important in the context of patient prognosis and survival
HIF-1alpha expression profile in intratumoral and peritumoral inflammatory cells as a prognostic marker for squamous cell carcinoma of the oral cavity
(Public Library of Science, 2014-01-09) Mendes, Suzanny Oliveira; Santos, Marcelo dos; Peterle, Gabriela Tonini; Maia, Lucas de Lima; Stur, Elaine; Agostini, Lidiane Pignaton; Carvalho, Marcos Brasilino de; Tajara, Eloiza Helena; Louro, Iúri Drumond; Trivilin, Leonardo Oliveira; Silva-Conforti, Adriana Madeira Álvares da
The HIF-1 transcriptional complex is responsible for controlling transcription of over 100 genes involved in cell hypoxia response. HIF-1alpha subunit is stabilized in hypoxia conditions, creating the HIF-1 nuclear transcription factor. In inflammatory cells, high HIF-1alpha expression induces lymphocytic immunosuppression, decreasing tumoral antigen recognition, which promotes tumor growth. The present work investigated the relationship between HIF-1alpha expression in lymphocytes populating the intratumoral and peritumoral region of 56 patients with oral cancer. Our data indicates a prognostic value for this expression. High HIF-1alpha expression in peritumoral inflammatory cells is significantly related to worse patient outcome, whereas high expression in the intratumoral lymphoid cells correlates with a better prognosis. A risk profile indicating the chance of disease relapse and death was designed based on HIF-1alpha expression in tumoral inflammatory cells, defining low, intermediate and high risks. This risk profile was able to determine that high HIF-1alpha expression in peritumoral cells correlates with worse prognosis, independently of intratumoral expression. Low HIF-1alpha in tumor margins and high expression in the tumor was considered a low risk profile, showing no cases of disease relapse and disease related death. Intermediate risk was associated with low expression in tumor and tumor margins. Our results suggest that HIF-1alpha expression in tumor and peritumoral inflammatory cells may play an important role as prognostic tumor marker
JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma
(Public Library of Science, 2018-03-28) Maia, Lucas de Lima; Peterle, Gabriela Tonini; Santos, Marcelo dos; Trivilin, Leonardo Oliveira; Mendes, Suzanny Oliveira; Oliveira, Mayara Mota de; Santos, Joaquim Gasparini dos; Stur, Elaine; Agostini, Lidiane Pignaton; Couto, Cinthia Vidal Monteiro da Silva; Dalbo, Juliana; Assis, Arícia Leone Evangelista Monteiro de; Archanjo, Anderson Barros; Mercante, Ana Maria Da Cunha; Lopez, Rossana Veronica Mendoza; Nunes, Fábio Daumas; Carvalho, Marcos Brasilino de; Tajara, Eloiza Helena; Louro, Iúri Drumond; Álvares-da-Silva, Adriana Madeira
Aims: Jumonji Domain-Containing 1A (JMJD1A) protein promotes demethylation of histones, especially at lysin-9 of di-methylated histone H3 (H3K9me2) or mono-methylated (H3K9me1). Increased levels of H3 histone methylation at lysin-9 (H3K9) is related to tumor suppressor gene silencing. JMJD1A gene target Adrenomeduline (ADM) has shown to promote cell growth and tumorigenesis. JMJD1A and ADM expression, as well as H3K9 methylation level have been related with development risk and prognosis of several tumor types. Methods and results: We aimed to evaluate JMJD1A, ADM, H3K9me1 and H3K9me2expression in paraffinembedded tissue microarrays from 84 oral and oropharyngeal squamous cell carcinoma samples through immunohistochemistry analysis. Our results showed that nuclear JMJD1A expression was related to lymph node metastasis risk. In addition, JMJD1A cytoplasmic expression was an independent risk marker for advanced tumor stages. H3K9me1 cytoplasmic expression was associated with reduced disease-specific death risk. Furthermore, high H3K9me2 nuclear expression was associated with worse specific-disease and disease-free survival. Finally, high ADM cytoplasmic expression was an independent marker of lymph node metastasis risk. Conclusion: JMJD1A, H3K9me1/2 and ADM expression may be predictor markers of progression and prognosis in oral and oropharynx cancer patients, as well as putative therapeutic targets
Keratins 17 and 19 expression as prognostic markers in oral squamous cell carcinoma
(Fundação de Pesquisas de Ribeirão Preto, 2015-11-24) Coelho, B. A.; Peterle, G. T.; Santos, Marcelo dos; Agostini, Lidiane Pignaton; Maia, L. L.; Stur, E.; Silva, C. V. M.; Mendes, Suzanny Oliveira; Almança, Carlos Cesar Jorden; Freitas, Flávia Vitorino; Borçoi, Aline Ribeiro; Archanjo, Anderson Barros; Mercante, A. M. C.; Nunes, Fabio Daumas; Carvalho, M. B.; Silva, Eloiza Helena Tajara da; Louro, Iuri Drummond; Silva-Conforti, A. M. A
Five-year survival rates for oral squamous cell carcinoma (OSCC) are 30% and the mortality rate is 50%. Immunohistochemistry panels are used to evaluate proliferation, vascularization, apoptosis, HPV infection, and keratin expression, which are important markers of malignant progression. Keratins are a family of intermediate filaments predominantly expressed in epithelial cells and have an essential role in mechanical support and cytoskeleton formation, which is essential for the structural integrity and stability of the cell. In this study, we analyzed the expressions of keratins 17 and 19 (K17 and K19) by immunohistochemistry in tumoral and non-tumoral tissues from patients with OSCC. The results show that expression of these keratins is higher in tumor tissues compared to non-tumor tissues. Positive K17 expression correlates with lymph node metastasis and multivariate analysis confirmed this relationship, revealing a 6-fold increase in lymph node metastasis when K17 is expressed. We observed a correlation between K17 expression with disease-free survival and disease-specific death in patients who received surgery and radiotherapy. Multivariate analysis revealed that low expression of K17 was an independent marker for early disease relapse and disease-specific death in patients treated with surgery and radiotherapy, with an approximately 4-fold increased risk when compared to high K17 expression. Our results suggest a potential role for K17 and K19 expression profiles as tumor prognostic markers in OSCC patients
PAI-1, CAIX, and VEGFA expressions as prognosis markers in oral squamous cell carcinoma
(John Wiley and Sons, 2018-05) Peterle, Gabriela Tonini; Maia, Lucas Lima; Trivilin, Leonardo Oliveira; Oliveira, Mayara Mota de; Santos, Joaquim Gasparini dos; Mendes, Suzanny Oliveira; Stur, Elaine; Agostini, Lidiane Pignaton; Rocha, Lília Alves; Moysés, Raquel Ajub; Cury, Patrícia Maluf; Nunes, Fábio Daumas; Louro, Iúri Drumond; Santos, Marcelo dos; Silva, Adriana Madeira Alvares da
Background: In oral squamous cell carcinoma (OSCC), the HIF-1 complex promotes the expression of genes involved in specific mechanisms of cell survival under hypoxic conditions, such as plasminogen activator inhibitor-1 (PAI-1), carbonic anhydrase 9 (CAIX), and vascular endothelial growth factor A (VEGFA). The study aimed to investigate the presence and prognostic value of PAI-1, CAIX, and VEGFA in OSCC. Materials and Methods: Immunohistochemistry was used to analyze the expressions of these proteins in 52 tumoral tissue samples of patients with OSCC, surgically treated and followed by a minimum of 24 months after surgery. The correlations between protein expressions and clinicopathological parameters and prognosis were analyzed. Results: Positive PAI-1 membrane expression was significantly associated with local disease relapse (P = .027). Multivariate analysis revealed that the positive PAI-1 membrane expression is an independent marker for local disease relapse, with approximately 14-fold increased risk when compared to negative expression (OR = 14.49; CI = 1.40-150.01, P = .025). Strong PAI-1 cytoplasmic expression was significantly associated with the less differentiation grade (P = .027). Strong CAIX membrane expression was significantly associated with local disease-free survival (P = .038). Positive CAIX cytoplasmic expression was significantly associated with lymph node affected (P = .025) and with disease-specific survival (P = .022). Multivariate analysis revealed that the positive CAIX cytoplasmic expression is an independent risk factor for disease-related death, increasing their risk approximately 3-fold when compared to negative expression (HR = 2.84; CI = 1.02-7.87, P = .045). Positive VEGFA cytoplasmic expression was significantly associated with less differentiation grade (P = .035). Conclusion: Our results suggest a potential role for these expressions profiles as tumor prognostic markers in OSCC patients

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Navegando por Autor "Mendes, Suzanny Oliveira"