Navegando por Autor "Nascimento, Paulo Ricardo Porfírio do"
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Artigo Acute effects of high-intensity interval and moderate-intensity continuous exercise on GLP-1, appetite and energy intake in obese men: a crossover trial(Nutrients, 2018-07) Fayh, Ana Paula Trussardi; Matos, Victor Araújo Ferreira; Souza, Daniel Costa de; Santos, Victor Oliveira Albuquerque dos; Medeiros, Ítalo Freire; Browne, Rodrigo Alberto Vieira; Nascimento, Paulo Ricardo Porfírio do; Marinho, Cristiane da Silva Ramos; Serquiz, Alexandre Coelho; Costa, Eduardo CaldasThis study investigated the effect of high-intensity interval (HIIE) and moderate-intensity continuous exercise (MICE) on glucagon-like peptide 1 (GLP-1), appetite and energy intake (EI) in obese men. In a randomized crossover trial, 12 participants (28.4 ± 2.6 years, 35.5 ± 4.5 kg/m2 , 39.8 ± 2.2% body fat) performed: (I) Control (CON, no exercise); (II) MICE (20 min, 70% of maximal heart rate) and (III) HIIE (10 × 1 min at 90% of maximal heart rate with 1 min recovery). GLP-1 and appetite were assessed at: (I) PRE: pre-exercise; (II) POST: immediately post-exercise; (III) POST-1 h: 1 h post-exercise. EI was assessed after an ad libitum meal offered 1 h post-exercise and over 24 h. There was a significant time × condition interaction for GLP-1 (p = 0.035). Higher GLP-1 levels in MICE vs. CON (p = 0.024) and a trend for HIIE vs. CON (p = 0.069) POST-1h was found. Hunger was reduced immediately post-HIIE compared to CON (p < 0.01), but was not sustained POST-1 h (p > 0.05). EI did not differ between the sessions 1 h post-exercise or over 24H (p > 0.05). In summary, although MICE increased GLP-1 levels POST-1h and HIIE induced a transient reduction in hunger, both exercise protocols did not impact EI in obese menArtigo Effects of high-intensity interval and moderate-intensity continuous exercise on inflammatory, leptin, iga, and lipid peroxidation responses in obese males(Frontiers in Physiology, 2018-05) Fayh, Ana Paula Trussardi; Souza, Daniel Costa de; Matos, Victor Araújo Ferreira; Santos, Victor Oliveira Albuquerque dos; Medeiros, Ítalo Freire; Marinho, Cristiane da Silva Ramos; Dorneles, Gilson Pires; Peres, Alessandra; Muller, Carlos Henrique de Lemos; Krause, Maurício; Nascimento, Paulo Ricardo Porfírio do; Costa, Eduardo CaldasPurpose: To compare the effects of a single high-intensity interval exercise session (HIIE) with a moderate-intensity continuous exercise session (MICE) on the inflammatory profile, IgA levels, and lipid peroxidation in sedentary obese males. Methods: Ten sedentary obese men (age 28.5 ± 2.7 years; BMI 35.9 ± 4.9 kg/m2; body fat 40.6 ± 2.0%) performed three experimental sessions, on separate days with 1 week wash-out period between interventions, according to a randomized order: (1) HIIE: 10 × 60 s at 90% of the HRmax alternated by 60 s of active recovery; (2) MICE: 20 min at 70% of the HRmax; (3) Rest—control. Blood and saliva samples were collected before, immediately after and 60 min after the end of each session in order to analyse serum levels of cytokines, IgA, and lipoperoxidation markers. Results: Leptin levels decreased immediately after HIIE (P = 0.033) and was different from the MICE (P = 0.025). IFN-γ levels were reduced immediately after (P = 0.032) and 60 min after HIIE (P = 0.003) compared to baseline, and it also increased IL-4 levels immediately after exercise (P = 0.007) compared to resting values. MICE promoted an increase in IFN-γ levels immediately after exercise (P = 0.025) and 60 min after exercise (P = 0.004) in relation to baseline. Both exercise conditions increased IL-6 levels up to 60 min after exercise (P < 0.05). The IFN-γ/IL-4 ratio decreased immediately after (P = 0.002) and 60 min after HIIE (P = 0.005) in relation to pre-exercise. No changes were found for IgA-S and TBARS for any of the conditions. Conclusion: A single HIIE session is able to decrease IFN-γ/IL-4 ratio, indicating an anti-inflammatory response, without alterations in the function of the mucosal immune system and lipoperoxidation. On the other hand, a brief session of MICE induced changes in the pattern of cytokines associated with increased cellular immune functionTCC Infecção de flebotomíneos por Leishmania infantum em áreas endêmicas para leishmaniose visceral e suas principais fontes de alimentação(Universidade Federal do Rio Grande do Norte, 2022-12-12) Falcão, Angelis Maria Alves; Jerônimo, Selma Maria Bezerra; Galvão, Joanna Gardel Valverde; http://lattes.cnpq.br/0166507910755600; http://lattes.cnpq.br/7120263570947836; Lima, Ádila Lorena Morais; http://lattes.cnpq.br/9763259490465317; Nascimento, Paulo Ricardo Porfírio do; http://lattes.cnpq.br/8264947715441785A leishmaniose visceral (LV) é uma doença de ocorrência frequente nas áreas tropicais e subtropicais e permanece como problema de saúde pública em vários países. No Brasil, a taxa de infecção sintomática e assintomática por Leishmania infantum, agente etiológico da LV no Brasil e na Europa, é elevada em áreas focais. O ciclo de transmissão é antropozoonótico, sendo o cão doméstico considerado o principal reservatório e fonte de alimentação para as fêmeas hematófogas de flebotomíneos, sobretudo para a espécie de caráter oportunista Lutzomyia longipalpis, vetor de maior importância epidemiológica nas Américas. Esse estudo teve por objetivo determinar a taxa de infecção vetorial para Leishmania infantum e principais fontes de alimentação dos flebotomíneos nas regiões de Nordelândia, África e São Gonçalo do Amarante, áreas endêmicas para LV na Grande Natal - RN. Para isso, foram realizadas coletas semanais entre setembro de 2020 e setembro de 2022 com armadilhas tipo CDC (Center for Disease Control) em peridomicílio de 20 residências que aceitaram participar. Foram coletados 2494 flebotomíneos, sendo 83,8% (n=2090) machos e 16,2% (n=404) fêmeas. Em África e Nordelândia, áreas urbanas de Natal, houve maior captura de flebotomíneos total e fêmeas entre os meses de abril e maio, período mais chuvoso, enquanto em Nova Zelândia, área rural de São Gonçalo do Amarante, estes picos foram em outubro, período mais seco, poém o período de coleta nessa região foi menor. Dentre as 404 fêmeas capturadas, após dosagem e análise de pureza por Nanodrop e testagem para presença de DNA de L. longipalpis, 64,3% (n=260) possuía integridade do DNA e estava apto para realização de qPCR para infecção por L. infantum e fontes alimentares, enquanto 35,7% (n=144) eram amostras degradadas ou não L. longipalpis e foram descartadas. Detectamos por qPCR 16,2% (n=42) de positividade para L. infantum, principalmente em São Gonçalo, responsável por 83,3% (n= 35) das amostras positivas, seguido por Nordelândia 12% (n=5) e África com 4,7% (n= 2). Foi então avaliada a presença de DNA de algumas espécies de vertebrados presentes na área (cão, humano, galinha, gato e cavalo) como possíveis fontes de alimentação dos flebotomíneos. A maior frequência foi galinha 11,7% (n=43) e depois humano 4,1% (n=15). Além disso, houve alimentação mista humano/galinha 0,8% (n=3), gato/galinha 0,3% (n=1) e de cão/galinha 0,3% (n=1). Entre as 42 fêmeas positivas para infecção por L. infantum, 4 haviam realizado alimentação em cão e 3 em galinha. A presença de fêmeas L. longipalpis infectadas e realizando repasto em animais domésticos e humanos evidencia a presença de Leishmania em animais residentes na Grande Natal e sinaliza para a necessidade em se estudar a dinâmica e hábitos desses vetores como forma de controle da LV.Artigo Nutritional status and appetite-regulating hormones in early treatment of acute lymphoblastic leukemia among children and adolescents: a cohort study(Sao Paulo Medical Journal, 2020) Fayh, Ana Paula Trussardi; Gomes, Camila de Carvalho; Silva, Cassia Camila Gomes da; Nascimento, Paulo Ricardo Porfírio do; Lemos, Telma Maria de Araújo Moura; Marcadenti, Aline; Markoski, Melissa MedeirosBACKGROUND: Children with acute lymphoblastic leukemia are at risk of malnutrition, but few studies have described the changes in nutritional status during the different phases of chemotherapy. OBJECTIVE: To evaluate changes in nutritional status, food intake and appetite-regulating hormones among children and adolescents with acute lymphoblastic leukemia in the first phase of chemotherapy. DESIGN AND SETTING: Cohort study developed in the pediatric oncology departments of two hospitals in the city of Natal, Rio Grande do Norte, Brazil. METHODS: Fourteen children/adolescents (mean age of 7 years; 50% female) with acute lymphoblastic leukemia were monitored over the 28 days of an induction chemotherapy cycle. Anthropometric measurements, 24-hours food weight records and appetite-regulating hormone levels (ghrelin, leptin, insulin and cortisol) were obtained at three different times (before, in the middle and at the end of the induction phase). RESULTS: Most of the patients (85.7%) had normal weight at the beginning of the treatment, and this did not change significantly during the 28 days. Energy and nutrient intakes improved from the start of the treatment to the midpoint, according to the ghrelin levels (from 511.1 ± 8.3 to 519.3 ± 6.6 pg/ml; P = 0.027). Other appetite-regulating hormones did not present changes. CONCLUSION: Food consumption improves during the first phase of treatment, without alterations in anthropometric nutritional statusArtigo A single session of low-volume highintensity interval and moderateintensity continuous exercise elicits a transient reduction in ghrelin levels, but not in post-exercise energy intake in obese men(Archives of Endocrinology and Metabolism, 2021) Fayh, Ana Paula Trussardi; Matos, Victor Araújo Ferreira; Souza, Daniel Costa de; Browne, Rodrigo Alberto Vieira; Santos, Victor Oliveira Albuquerque dos; Medeiros, Ítalo Freire; Nascimento, Paulo Ricardo Porfírio do; Costa, Eduardo CaldasObjective: This study investigated the acute effects of high-intensity interval (HIIE) and moderateintensity continuous (MICE) exercise on ghrelin levels in obese men. Subjects and methods: Atotal of 10 obese men (age 27.6 ± 1.8 years, body mass index 35.4 ± 4.5 kg/m², body fat 39.9 ± 2.1%)performed two exercise sessions in a randomized order: HIIE (10 x 1 min intervals at 90% of themaximal heart rate [HRmax] interspersed by 1 min of active recovery) and MICE (20 min at 70% ofthe HRmax). Ghrelin levels were assessed pre-, post- and 1h post-exercise, and energy intake wasassessed 1h post-exercise through an ad libitum meal. Results: HIIE and MICE showed a trend todecrease ghrelin levels immediately post-exercise (-14.1 ± 21.6% and -9.6 ± 23.8%, respectively, p= 0.07) and decreased 1h post-exercise (-12.7 ± 31.8% and -13.8 ± 21.7%, respectively, p < 0.05). Nochanges were observed for post-exercise energy intake (p > 0.05). There was a positive correlationbetween the change in ghrelin levels and post-exercise energy intake only for HIIE (r = 0.63, p =0.05). Conclusion: In summary, a single session of HIIE and MICE elicits a reduction on ghrelin levelswithout changing post-exercise energy intake in obese men