Navegando por Autor "Oliveira, Juliana Marinho de"
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Artigo Association of serum alpha-tocopherol and retinol with the extent of coronary lesions in coronary artery disease(Journal of Nutrition and Metabolism, 2018-12-11) Ribeiro, Karla Danielly da Silva; Miranda, Carolinne Thaísa de Oliveira Fernandes; Duarte, Victor Hugo Rezende; Cruz, Marina Sampaio de Menezes; Duarte, Mychelle Kytchia Rodrigues Nunes; Araújo, Jéssica Nayara Góes de; Santos, Ayda Maria Quirino Silva dos; Oliveira, Juliana Marinho de; Paiva, Maria Sanali Moura Oliveira; Rezende, Adriana Augusto; Hirata, Mario Hiroyuki; Hirata, Rosario Dominguez Crespo; Luchessi, André Ducati; Silbiger, Vivian Nogueira; https://orcid.org/0000-0001-7708-4271; https://orcid.org/0000-0003-3073-5967; https://orcid.org/0000-0002-9252-0278; https://orcid.org/0000-0002-2251-5967; https://orcid.org/0000-0002-3122-9073; https://orcid.org/0000-0002-2276-690X; https://orcid.org/0000-0003-2452-4047; https://orcid.org/0000-0002-9521-7979; https://orcid.org/0000-0002-2758-8102Background and aims: Fat-soluble vitamins play an important role in the pathogenesis of cardiovascular disease and progression ofatherosclerosis. +is study aimed at investigating the relationship of the serum levels of alpha-tocopherol and retinol with theextent of coronary lesions in patients with coronary artery disease. Methods. Patients with coronary artery disease (n = 177) aged 30 – 74 years, who underwent their first coronary angiography, were enrolled. The extent of coronary lesions was assessed using th eFriesinger index (FI). Accordingly, patients were grouped as follows: FI = 0–4 (n = 90), FI = 5–9 (n = 50), and FI = 10–15 (n = 37).Serum levels of vitamins were determined via high-performance liquid chromatography and serum biochemical analysis. Results.Assessment of FI-based groups revealed that 50.8% patients had a coronary artery lesion to a low extent (FI 0–4). Individuals inthis group were younger and had lower glucose and serum alpha-tocopherol levels than the other groups (p < 0.05). Low levels of alpha-tocopherol were more frequent in the FI 0–4 group than that in the other groups (p = 0.03). No difference was observedbetween the mean serum retinol levels among the FI-based groups (n = 0.492), and the low frequency of retinol was consistentamong the FI groups (n = 0.348). Conclusions. The low level of alpha-tocopherol together with the presence of dyslipidemia isprobably associated with the initial events in atherosclerosis. Increased alpha-tocopherol levels in patients with more extensivecoronary artery lesions may have resulted from altered vitamin E metabolism with increased oxidative stress.Artigo The relationship of the oleic acid level and ECHDC3 mRNA expression with the extent of coronary lesion(Lipids in Health and Disease, 2016) Lima, Severina Carla Vieira Cunha; Duarte, Mychelle Kytchia Rodrigues Nunes; Araújo, Jéssica Nayara Góes de; Duarte, Victor Hugo Rezende; Oliveira, Katiene Macêdo de; Oliveira, Juliana Marinho de; Carioca, Antonio Augusto Ferreira; Bortolin, Raul Hernandes; Rezende, Adriana Augusto; Hirata, Mario Hiroyuki; Hirata, Rosário Domingues; Waitzberg, Dan Linetzky; Luchessi, André Ducati; Silbiger, Vivian Nogueira; https://orcid.org/0000-0001-8268-1986Background: The fatty acid profile is associated with the risk and progression of several diseases, probably via mechanisms including its influence on gene expression. We previously reported a correlation between ECHDC3 upregulation and the severity of acute coronary syndrome. Here, we assessed the relationship of serum fatty acid profile and ECHDC3 expression with the extent of coronary lesion. Methods: Fifty-nine individuals aged 30 to 74 years and undergoing elective cinecoronariography for the first time were enrolled in the present study. The extent of coronary lesion was assessed by the Friesinger index and patients were classified as without lesion (n = 18), low lesion (n = 17), intermediate lesion (n = 17) and major lesion (n = 7). Serum biochemistry, fatty acid concentration, and ECHDC3 mRNA expression in blood were evaluated. Results: Elevated serum levels of oleic acid and total monounsaturated fatty acids were observed in patients with low and intermediate lesion, when compared to patients without lesion (p < 0.05). ECHDC3 mRNA expression was 1. 2 fold higher in patients with low lesion than in patients without lesion (p = 0.020), and 1.8 fold lower in patients with major lesion patients than in patients with low lesion (p = 0.023). Conclusion: Increased levels of monounsaturated fatty acids, especially oleic acid, and ECHDC3 upregulation in patients with coronary artery lesion suggests that these are independent factors associated with the initial progression of cardiovascular disease.