Navegando por Autor "Pedrosa, Lucia Fatima Campos"
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Artigo Are phosphatidylcholine and lysophosphatidylcholine body levels potentially reliable biomarkers in obesity?: a review of human studies(Molecular Nutrition & Food Research, 2023-01) Reis, Bruna Zavarize; Bellot, Paula Emília Nunes Ribeiro; Moia, Melissa Nunes; Pedrosa, Lucia Fatima Campos; Tasic, Ljubica; Barbosa, Fernando; Evangelista, Karine Cavalcanti Maurício SenaPhosphatidylcholines (PCs) are the major components of biological membranes in animals and are a class of phospholipids that incorporate choline as a headgroup. Lysophosphatidylcholines (LPCs) are a class of lipid biomolecules derived from the cleavage of PCs, and are the main components of oxidized low-density lipoproteins (oxLDLs) that are involved in the pathogenesis of atherosclerosis. Since obesity is associated with a state of chronic low-grade inflammation, one can anticipate that the lipidomic profile changes in this context and both PCs and LPCs are gaining attention as hypothetically reliable biomarkers of obesity. Thus, a literature search is performed on PubMed, Latin American and Caribbean Health Science Literature (LILACS), and Excerpta Medica DataBASE (Embase) to obtain the findings of population studies to clarify this hypothesis. The search strategy resulted in a total of 2403 reports and 21 studies were included according to the eligibility criteria. Controversial data on the associations of PCs and LPCs with body mass index (BMI) and body fat parameters have been identified. There is an inverse relationship between BMI and most species of PCs, and a majority of studies exhibited negative associations between BMI and LPCs. Other findings regarding the differences between PCs and LPCs in obesity are presented, and the associated uncertainties are discussed in detailArtigo Association between exposure to plasma mixture of essential and toxic elements and the lipid profile in institutionalized older adults(Journal of Trace Elements in Medicine and Biology, 2024-09) Evangelista, Karine Cavalcanti Maurício de Sena; Pacheco, Daniela Antunes; Campêlo, Angélica Lopes de Sousa; Sousa, Sara Estéfani Soares de; Sales, Márcia Cristina; Barbosa Júnior, Fernando; Lima, Kenio Costa; Ferreira, Marcelo Rodrigo Portela; Reis, Bruna Zavarize; Pedrosa, Lucia Fatima CamposBackground: Older adults have a progressive deficiency in the ability to detoxify chemical elements and are susceptible to dyslipidemia and changes in glycemic control. The objective was to evaluate the association of the mixture of essential and toxic elements in the plasma of institutionalized older adults and test the associations with lipid profile variables and glycemic control. Methods: Data were obtained from 149 Brazilian older adults aged ≥60 living in nursing homes (NH) in Natal, Brazil. The concentrations of sixteen chemical elements in plasma and lipid profile parameters and glycemic control of 149 institutionalized older adults were measured. Bayesian kernel machine regression was used to estimate the associations of the mixture of chemical elements with total cholesterol (TC), high-density lipoprotein (HDL-c), low-density lipoprotein (LDL-c), triglycerides (TG), fasting glucose, and glycated hemoglobin. ResultsNon-linear responses to exposure were observed for iron (Fe) about TC, LDL-c, and TG, and for barium (Ba) and copper (Cu) about TG. The concentration of the mixture of chemical elements below the 35th percentile was associated with a decrease in TC. Fe was the main element in the effect of the mixture associated with TC.ConclusionsThe lower concentrations of the mixture of chemical elements in plasma had a protective effect on the increase in TC, with Fe being the main element. Considering the results, the levels of essential and toxic elements in the plasma of older adults require extensive screening, mainly to prevent dyslipidemia and monitor clinical interventionsArtigo Biomarkers of zinc and copper status and associated factors in outpatients with ischemic and non-ischemic heart failure(Journal of the American Nutrition Association, 2022-02) Evangelista, Karine Cavalcanti Maurício de Sena; Freire, Fernanda Lambert de Andrade; Komatsu, Raquel Costa Silva Dantas; Lira, Niethia Regina Dantas de; Diniz, Rosiane Viana Zuza; Lima, Severina Carla Vieira Cunha; Barbosa, Fernando; Pedrosa, Lucia Fatima CamposBackground: Few studies have explored the impact of ischemic and non-ischemic etiologies of heart failure and other factors associated with heart failure on zinc and copper status. This study examined zinc and copper status in 80 outpatients with ischemic (n ¼ 36) and non-ischemic (n ¼ 44) heart failure and associations with biodemographic, clinical, biochemical, and nutritional parameters. Materials: Biomarkers of plasma zinc and copper, copper-zinc ratio, 24-h urinary zinc excretion, ceruloplasmin, and dietary intake of zinc and copper were assessed. Plasma zinc and copper and urinary zinc were measured by inductively coupled plasma mass spectrometry (ICP-MS). Results: Patients with ischemic heart failure showed lower dietary zinc intake and higher dietary copper intake (both p ¼ 0.02). Zinc and copper in plasma, copper-zinc ratio, ceruloplasmin, and 24-h urinary zinc excretion showed no statistical differences between the groups (all p 0.05). An inverse association was found between age (b ¼0.001; p ¼ 0.005) and the use of diuretics (b ¼ -0.047; p ¼ 0.013) and plasma zinc. Copper levels in plasma (b = 0.001; p < 0.001), and albumin (b ¼ 0.090; p<0.001) were directly associated with plasma zinc. A positive association was found between ceruloplasmin (b ¼ 0.011; p < 0.001), gamma-glutamyl transferase (b ¼ 0.001; p < 0.001), albumin (b ¼ 0.077; p ¼ 0.001), and high-sensitivity c-reactive protein (b ¼ 0.001; p ¼ 0.024) and plasma copper. Conclusion: Zinc and copper biomarkers in clinically stable patients with heart failure did not seem to be responsive to the differences in zinc and copper intake observed in this study, regardless of heart failure etiology. The predictors of plasma zinc and copper levels related to oxidative stress and inflammation should be monitored in heart failure clinical practiceArtigo Biomarkers of zinc and copper status and associated factors in outpatients with ischemic and non-ischemic heart failure(Journal of the american college of nutrition, 2022) Lima, Severina Carla Vieira Cunha; Freire, Fernanda Lambert de Andrade; Komatsu, Raquel Costa Silva Dantas; Lira, Niethia Regina Dantas de; Diniz, Rosiane Viana Zuza; Barbosa Junior, Fernando; Pedrosa, Lucia Fatima Campos; Evangelista, Karine Cavalcanti Mauricio Sena; https://orcid.org/0000-0001-8268-1986Background: Few studies have explored the impact of ischemic and non-ischemic etiologies of heart failure and other factors associated with heart failure on zinc and copper status. This study examined zinc and copper status in 80 outpatients with ischemic (n ¼ 36) and non-ischemic (n ¼ 44) heart failure and associations with biodemographic, clinical, biochemical, and nutri- tional parameters. Materials: Biomarkers of plasma zinc and copper, copper-zinc ratio, 24-h urinary zinc excretion, ceruloplasmin, and dietary intake of zinc and copper were assessed. Plasma zinc and copper and urinary zinc were measured by inductively coupled plasma mass spectrometry (ICP-MS). Results: Patients with ischemic heart failure showed lower dietary zinc intake and higher dietary copper intake (both p ¼ 0.02). Zinc and copper in plasma, copper-zinc ratio, ceruloplasmin, and 24-h urinary zinc excretion showed no statistical differences between the groups (all p 0.05). An inverse association was found between age (b ¼ 0.001; p ¼ 0.005) and the use of diuretics (b ¼ -0.047; p ¼ 0.013) and plasma zinc. Copper levels in plasma (b = 0.001; p < 0.001), and albumin (b ¼ 0.090; p<0.001) were directly associated with plasma zinc. A positive association was found between ceruloplasmin (b ¼ 0.011; p < 0.001), gamma-glutamyl transferase (b ¼ 0.001; p < 0.001), albumin (b ¼ 0.077; p ¼ 0.001), and high-sensitivity c-reactive protein (b ¼ 0.001; p ¼ 0.024) and plasma copper. Conclusion: Zinc and copper biomarkers in clinically stable patients with heart failure did not seem to be responsive to the differences in zinc and copper intake observed in this study, regard- less of heart failure etiology. The predictors of plasma zinc and copper levels related to oxidative stress and inflammation should be monitored in heart failure clinical practice.Artigo Dietary patterns of young adolescents in urban areas of northeast Brazil(Nutrición Hospitalaria, 2013) Morais, Célia Márcia Medeiros de; Pinheiro, Liana Galvão Bacurau; Lima, Severina Carla Vieira Cunha; Evangelista, Karine Cavalcanti Mauricio de Sena; Lima, Kenio Costa; Pedrosa, Lucia Fatima CamposBackground: Temporal trends in dietary patterns reveal associations between food consumption and increased prevalence of non-communicable chronic diseases. Objectives: This study characterized dietary patterns in adolescents in urban area located in northeast of Brazil, relating it to the markers of a healthy diet. Methods: A cross-sectional study used two 24-hour recalls to assess dietary intake in 430 public school students from Natal-RN, Brazil. Principal component analysis was used to derive dietary patterns according to consumption of food based on weight (grams), energy (Kcal), or fiber (grams). These models resulted in a number of different main components, 7, 8 and 4, respectively (cumulative variance >70%; factor loadings >0.4). The association between independent variables and the factor scores of all components obtained was determined by the Prevalence Ratio (CI 95%). Results: The dietary patterns derived were: (1) Pure Traditional Food System, the highly representative pattern in young adolescents and the first component of the analytical models, (2) Combined and Risk Food System; extraction of total food weight and energy revealed markers of unhealthy diets based on high sugar, saturated fat, and salt consumption, and (3) Modified Traditional Food System represented by fiber; pattern 1 was observed within this model too. The associations observed, predominantly from the TFSm pattern, distinguished by sex, age and nutritional status. Conclusions: Patterns 1 and 3 are characterized by preserved regional food practices that prevent chronic disease, whereas pattern 2 is characterized by health risks. These inter-sectorial findings should be considered in the development of health care policies for children and adolescentsArtigo Effects of vitamin D supplementation on cardiometabolic parameters among patients with metabolic syndrome: a systematic review and grade evidence synthesis of randomized controlled trials(Heliyon, 2023-11) Evangelista, Karine Cavalcanti Maurício de Sena; Aquino, Séphora; Cunha, Aline; Lima, Josivan Gomes; Oliveira, Antonio Gouveia; Cobucci, Ricardo Ney; Pedrosa, Lucia Fatima CamposVarious pathophysiologic mechanisms were proposed to underlie the effect of vitamin D on MetS components. In this systematic review, we reviewed randomized control clinical trials to verify whether vitamin D supplementation (VDS) at different doses is effective concomitantly in controlling high-density lipoprotein cholesterol (HDL-c), triglycerides (TG), fasting glucose level, blood pressure, and central obesity in adults diagnosed with MetS. The following scientific databases were searched from 1998 until April 2023: EMBASE, MEDLINE (PubMed), Web of Science, Latin American and Caribbean Health Sciences Literature (Lilacs), the Cochrane Central Register of Controlled Trials, clinicaltrial.gov, and Google Scholar. No language restrictions were applied. Seven studies were included, and they showed a high level of heterogeneity. All studies reported a significant increase in serum 25(OH)D levels in the intervention groups. Of these, only two noted a significant decrease in triglyceride (TG) level and waist circumference. However, the certainty levels of the evidence rating were very low and low for triglyceride (TG) level and waist circumference, respectively, and moderate for fasting glucose level, blood pressure, and HDL-c. In conclusion, despite these benefits, considering the low certainty, the evidence does not support that VDS decreases triglyceride (TG) level and waist circumference in adults with MetSArtigo Effects of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with metabolic syndrome: a protocol for systematic review and meta-analysis of randomized controlled trials(Systematic Reviews, 2020-08) Evangelista, Karine Cavalcanti Maurício de Sena; Aquino, Séphora Louyse Silva; Cunha, Aline Tuane Oliveira; Lima, Josivan Gomes; Oliveira, Antonio Gouveia; Cobucci, Ricardo Ney; Pedrosa, Lucia Fatima CamposBackground: Vitamin D deficiency can play a role in extraskeletal functions that are involved with a set of risk factors associated with metabolic syndrome (MetS). The purpose of this review is to investigate the impact of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with MetS. Methods: EMBASE, Medline, Web of Science, Lilacs, the Cochrane Central Register of Controlled Trials, clinicaltrials.gov databases, and grey literature will be systematically searched for randomized controlled trials (RCTs) of vitamin D supplementation compared with placebo, through December 2020. We will include in the study patients with MetS diagnosed by the criteria set forth by the National Cholesterol Education Program Adult Treatment Panel III or the International Diabetes Federation. The effect of oral vitamin D supplementation on lipid profile improvement (triglycerides, high-density lipoprotein cholesterol—HDL-C) is this review’s primary outcome. The systematic review will be performed following the Preferred Reporting Items for Systematic Reviews and MetaAnalyses (PRISMA) guidelines. The study screening, data extraction, and quality assessment will be fulfilled by two independent reviewers according to the Cochrane Risk of Bias tool (RoB 2.0). The results of the systematic review will be provided according to the type of intervention, characteristics of the target population, the methods of measurement of vitamin D, the calculated vitamin D concentrations, types of biological samples, and types of outcomes. Meta-analyses will be conducted where appropriate. The Cochran’s Q test and the I 2 -heterogeneity test will be used to assess the presence of heterogeneity and whether the fixed or the random-effects model would be appropriate for combining study results using the inverse variance method or the DerSimonian-Lair method, respectively. Publication bias will be evaluated using funnel plots and Egger’s and Begg’s tests. The strength of the evidence will be assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Discussion: This systematic review will assess the effects of vitamin D supplementation on fasting glucose and triglyceride levels, waist circumference and mean blood pressure, and HDL-C among individuals with MetS. These findings may assist with decision-making within a clinical settingArtigo Frequency of metabolic syndrome and associated factors in institutionalized elderly individuals(Clinical Interventions in Aging, 2018) Lima, Severina Carla Vieira Cunha; Sales, Marcia Cristina; Oliveira, Larissa Praça; Liberalino, Laura Camila Pereira; Cunha, Aline Tuane Oliveira; Lemos, Telma Maria Araujo Moura; Lima, Kenio Costa; Evangelista, Karine Cavalcanti Mauricio Sena; Pedrosa, Lucia Fatima Campos; Sousa, Sara estefani soares; https://orcid.org/0000-0001-8268-1986Introduction: Population aging generally accompanies an increase in chronic noncommunicable diseases, such as metabolic syndrome (MS). Nursing homes have provided a solution for the decreased ability of elderly individuals for self-care and familial difficulties in meeting the health care needs of elderly individuals. Purpose: The aim of the present study was to determine the frequency of MS and its associated factors in elderly individuals living in nursing homes. Patients and methods: This cross-sectional study was conducted with 202 institutionalized elderly individuals. MS was diagnosed according to the National Cholesterol Education Program – Adult Treatment Panel III criteria. Sociodemographic, clinical, and lifestyle factors were assessed to verify their association with MS by logistic regression. Results: The MS frequency was 29.2%. The most frequent MS components were low high-density lipoprotein cholesterol level (63.9%) and abdominal obesity (42.7%). Factors associ-ated with MS were female sex (prevalence ratio [PR]=2.16; 95% CI, 1.04–4.49), age-adjusted institutionalization time .50% (PR=2.38, 95% CI, 1.46–3.88), and high concentrations of interleukin-6 (PR=2.01; 95% CI, 1.21–3.32) and tumor necrosis factor-α (PR=1.70; 95% CI, 1.05–2.77). Moreover, it was verified that the likelihood of having MS was 1.85-fold higher (95% CI, 1.11–3.10) in the group with a diet characterized by very high energy, very low fat, and high dietary fiber. Conclusion: The occurrence of MS in institutionalized elderly individuals was higher in females, and individuals with longer age-adjusted institutionalization time, higher concentrations of immunologic biomarkers, and a dietary intake consisting of higher energy and fiber and lower total fat. The results of the study are useful for guiding health care programs aimed at institutionalized elderly individuals.Artigo Frequency of metabolic syndrome and associated factors in institutionalized elderly individuals(Clinical Interventions in Aging, 2018-11) Evangelista, Karine Cavalcanti Maurício de Sena; Sales, Marcia; Oliveira, Larissa Praça; Liberalino, Laura Camila Pereira; Cunha, Aline Tuane Oliveira; Sousa, Sara Estefani Soares; Lemos, Telma Maria Araujo Moura; Lima, Severina Carla Vieira Cunha; Lima, Kenio Costa; Pedrosa, Lucia Fatima CamposIntroduction: Population aging generally accompanies an increase in chronic noncommunicable diseases, such as metabolic syndrome (MS). Nursing homes have provided a solution for the decreased ability of elderly individuals for self-care and familial difficulties in meeting the health care needs of elderly individuals. Purpose: The aim of the present study was to determine the frequency of MS and its associated factors in elderly individuals living in nursing homes. Patients and methods: This cross-sectional study was conducted with 202 institutionalized elderly individuals. MS was diagnosed according to the National Cholesterol Education Program – Adult Treatment Panel III criteria. Sociodemographic, clinical, and lifestyle factors were assessed to verify their association with MS by logistic regression. Results: The MS frequency was 29.2%. The most frequent MS components were low high density lipoprotein cholesterol level (63.9%) and abdominal obesity (42.7%). Factors associ ated with MS were female sex (prevalence ratio [PR]=2.16; 95% CI, 1.04–4.49), age-adjusted institutionalization time .50% (PR=2.38, 95% CI, 1.46–3.88), and high concentrations of interleukin-6 (PR=2.01; 95% CI, 1.21–3.32) and tumor necrosis factor-α (PR=1.70; 95% CI, 1.05–2.77). Moreover, it was verified that the likelihood of having MS was 1.85-fold higher (95% CI, 1.11–3.10) in the group with a diet characterized by very high energy, very low fat, and high dietary fiber. Conclusion: The occurrence of MS in institutionalized elderly individuals was higher in females, and individuals with longer age-adjusted institutionalization time, higher concentrations of immunologic biomarkers, and a dietary intake consisting of higher energy and fiber and lower total fat. The results of the study are useful for guiding health care programs aimed at institutionalized elderly individualsArtigo High prevalence of hypovitaminosis D in institutionalized elderly individuals is associated with summer in a region with high ultraviolet radiation levels(Nutrients, 2019-07) Evangelista, Karine Cavalcanti Maurício de Sena; Sousa, Sara Estéfani S.; Sales, Márcia Cristina; Araújo, José Rodolfo Torres; Lima, Kenio Costa; Pedrosa, Lucia Fatima CamposVitamin D may play a significant role in regulating the rate of aging. The objective of the study was to assess vitamin D status and its associated factors in institutionalized elderly individuals. A total of 153 elderly individuals living in Nursing Homes (NH) were recruited into the study. Serum 25-hydroxyvitamin D [25(OH)D] concentration was used as the biomarker of vitamin D status, and it was considered as the dependent variable in the model. The independent variables were the type of NH, age-adjusted time of institutionalization, age, sex, skin color, body mass index, waist and calf circumference, physical activity practice, mobility, dietary intake of vitamin D and calcium, vitamin D supplementation, use of antiepileptics, and season of the year. Serum 25(OH)D concentrations less than or equal to 29 ng/mL were classified as insufficient vitamin D status. The prevalences of inadequate dietary intake of vitamin D and calcium were 95.4% and 79.7%, respectively. The prevalence of hypovitaminosis D was 71.2%, and the mean serum concentration of 25(OH)D was 23.9 ng/mL (95% confidence interval [CI]: 22.8–26.1). Serum 25(OH)D concentration was associated with the season of summer (p = 0.046). There were no associations with other independent variables (all p > 0.05). The present results showed that a high prevalence of hypovitaminosis D was significantly associated with summer in institutionalized elderly individualsArtigo Inadequacies in the habitual nutrient intakes of patients with metabolic syndrome: a cross-sectional stud(Diabetology & Metabolic Syndrome, 2016-04) Evangelista, Karine Cavalcanti Maurício de Sena; Cunha, Aline Tuane Oliveira da; Pereira, Hermilla Torres; Aquino, Sephora Louyse Silva de; Sales, Cristiane Hermes; Lima, Josivan Gomes; Lima, Severina Carla Vieira Cunha; Pedrosa, Lucia Fatima CamposBackground: Dietary factors are important environmental factors associated with the prevalence of metabolic syn‑ drome (MS). The objective of this study was to assess the habitual nutrient intakes of patients with MS. Methods: A cross-sectional study included 103 patients (82 % women) with MS seen at the endocrinology outpa‑ tient clinic of Hospital Universitario Onofre Lopes. Habitual nutrient intake data were collected at two 24-h dietary recalls. Macronutrient intake adequacies were classified according to the I Brazilian guidelines for the diagnosis and treatment of metabolic syndrome. The prevalence of inadequate micronutrient intake was estimated using the esti‑ mated average requirements (EAR) cut-point method after adjusting for intra- and interpersonal variances and energy. Results: The mean energy intake of the included patients was 1523.0 ± 592.2 kcal/d, higher in men (1884.0 vs. 1441.5 kcal/d in women; p = 0.003). The recommended percentage protein intake was exceeded in both women and men (18 % in women and 19 % in men). Although men consumed more fiber (18.8 vs. 13.3 g/d in women; p = 0.011), their intake was still inadequate. Women consumed more fat (47.6 vs. 41.3 g/d in men; p = 0.007). The prevalence of inadequate vitamin D and calcium intakes exceeded 80 % in both men and women and across all age groups. The same was observed for magnesium in men and women aged more than 30 years. The prevalence of inadequate vitamin E, riboflavin, and zinc intakes in men ranged from 50 to 75 %. The prevalence of inadequate vitamin A, vitamin C, thiamin, vitamin B6, copper, and selenium intakes in men and women was less than 50 %. Conclusions: Patients with MS had high protein intake, low fiber intake, and high a prevalence of inadequate vitamin D, magnesium, and calcium intakesArtigo Lack of association between inadequate micronutrient intake and prognosis in outpatients with heart failure(Nutrients, 2022) Lima, Severina Carla Vieira Cunha; Torres, Núbia Rafaella Soares Moreira; Freire, Fernanda Lambert de Andrade; Komatsu, Raquel Costa Silva Dantas; Silva, Eduardo Paixão da; Queiroz, Salomão Israel Monteiro Lourenço; Lira, Niethia Regina Dantas de; Diniz, Rosiane Viana Zuza; Pedrosa, Lucia Fatima Campos; Lopes, Márcia Marília Gomes Dantas; Evangelista, Karine Cavalcanti Maurício Sena; https://orcid.org/0000-0001-8268-1986Inadequate nutrient intake can lead to worse outcomes in patients with heart failure (HF). This prospective cohort study aimed to assess the prevalence of inadequate micronutrient intake and their association with prognosis in 121 adult and elderly outpatients with HF. Habitual micronutrient intake was evaluated using 24-h dietary recalls (minimum 2 and maximum 6). Participants were grouped into moderate (n = 67) and high (n = 54) micronutrient deficiency groups, according to the individual assessment of each micronutrient intake. Patients’ sociodemographic, clinical, and anthropometric data and clinical outcomes (hospitalization and mortality) within 24 months were collected. Overall and event-free survival rates were calculated using Kaplan–Meier estimates, and curves were compared using the log-rank test. The death risk rate (hazard ratio (HR)) was calculated using Cox’s univariate model. The rate of inadequate intake was 100% for vitamins B1 and D and above 80% for vitamins B2, B9, and E, calcium, magnesium, and copper. No differences in overall survival and event-free survival were observed between groups of HF outpatients with moderate and high micronutrient deficiencies (HR = 0.94 (CI = 0.36–2.48), p = 0.91, and HR = 1.63 (CI = 0.68–3.92), p = 0.26, respectively), as well as when the inadequacy of each micronutrient intake was evaluated alone (all p > 0.05). In conclusion, a high prevalence of inadequate micronutrient intake was observed in outpatients with HF. Inadequate micronutrient intake was not associated with hospitalization and mortality in this group of patients.Artigo Lack of association between inadequate micronutrient Intake and prognosis in outpatients with heart failure(Nutrients, 2022) Lopes, Márcia Marília Gomes Dantas; Torres, Núbia Rafaella Soares Moreira; Freire, Fernanda Lambert de Andrade; Komatsu, Raquel Costa Silva Dantas; Silva, Eduardo Paixão da; Queiroz, Salomão Israel Monteiro Lourenço; Lira, Niethia Regina Dantas de; Diniz, Rosiane Viana Zuza; Lima, Severina Carla Vieira Cunha; Pedrosa, Lucia Fatima Campos; Evangelista, Karine Cavalcanti Maurício Sena; https://orcid.org/0000-0002-0011-576XInadequate nutrient intake can lead to worse outcomes in patients with heart failure (HF). This prospective cohort study aimed to assess the prevalence of inadequate micronutrient intake and their association with prognosis in 121 adult and elderly outpatients with HF. Habitual micronutrient intake was evaluated using 24-h dietary recalls (minimum 2 and maximum 6). Participants were grouped into moderate (n = 67) and high (n = 54) micronutrient deficiency groups, according to the individual assessment of each micronutrient intake. Patients’ sociodemographic, clinical, and anthropometric data and clinical outcomes (hospitalization and mortality) within 24 months were collected. Overall and event-free survival rates were calculated using Kaplan–Meier estimates, and curves were compared using the log-rank test. The death risk rate (hazard ratio (HR)) was calculated using Cox’s univariate model. The rate of inadequate intake was 100% for vitamins B1 and D and above 80% for vitamins B2, B9, and E, calcium, magnesium, and copper. No differences in overall survival and event-free survival were observed between groups of HF outpatients with moderate and high micronutrient deficiencies (HR = 0.94 (CI = 0.36–2.48), p = 0.91, and HR = 1.63 (CI = 0.68–3.92), p = 0.26, respectively), as well as when the inadequacy of each micronutrient intake was evaluated alone (all p > 0.05). In conclusion, a high prevalence of inadequate micronutrient intake was observed in outpatients with HF. Inadequate micronutrient intake was not associated with hospitalization and mortality in this group of patients.Artigo Plasma lipid metabolites as potential biomarkers for identifying individuals at risk of obesity-induced metabolic complications(Scientific Reports, 2023) Lima, Severina Carla Vieira Cunha; Bellot, Paula Emília Nunes Ribeiro; Braga, Erik Sobrinho; Omage, Folorunsho Bright; Nunes, Francisca Leide da; Lyra, Clélia Oliveira; Marchioni, Dirce Maria Lobo; Pedrosa, Lucia Fatima Campos; Barbosa Júnior, Fernando; Tasic, Ljubica; Evangelista, Karine Cavalcanti Maurício Sena; https://orcid.org/0000-0001-8268-1986Lipidomics studies have indicated an association between obesity and lipid metabolism dysfunction. This study aimed to evaluate and compare cardiometabolic risk factors, and the lipidomic profile in adults and older people. A cross-sectional study was conducted with 72 individuals, divided into two sex and age-matched groups: obese (body mass index—BMI ≥ 30 kg/m2; n = 36) and non-obese (BMI < 30 kg/m2; n = 36). The lipidomic profiles were evaluated in plasma using 1H nuclear magnetic resonance (1H-NMR) spectroscopy. Obese individuals had higher waist circumference (p < 0.001), visceral adiposity index (p = 0.029), homeostatic model assessment insulin resistance (HOMA-IR) (p = 0.010), and triacylglycerols (TAG) levels (p = 0.018). 1H-NMR analysis identified higher amounts of saturated lipid metabolite fragments, lower levels of unsaturated lipids, and some phosphatidylcholine species in the obese group. Two powerful machine learning (ML) models—k-nearest neighbors (kNN) and XGBoost (XGB) were employed to characterize the lipidomic profile of obese individuals. The results revealed metabolic alterations associated with obesity in the NMR signals. The models achieved high accuracy of 86% and 81%, respectively. The feature importance analysis identified signal at 1.50–1.60 ppm (–CO–CH2–CH2–, Cholesterol and fatty acid in TAG, Phospholipids) to have the highest importance in the two models.Artigo Plasma lipid metabolites as potential biomarkers for identifying individuals at risk of obesity-induced metabolic complications(Scientific Reports, 2023-07) Lyra, Clelia de Oliveira; Bellot, Paula Emília Nunes Ribeiro; Braga, Erik Sobrinho; Omage, Folorunsho Bright; Nunes, Francisca Leide da Silva; Lima, Severina Carla Vieira Cunha; Marchioni, Dirce Maria Lobo; Pedrosa, Lucia Fatima Campos; Barbosa, Fernando; Tasic, Ljubica; Evangelista, Karine Cavalcanti Maurício SenaLipidomics studies have indicated an association between obesity and lipid metabolism dysfunction. This study aimed to evaluate and compare cardiometabolic risk factors, and the lipidomic profle in adults and older people. A cross-sectional study was conducted with 72 individuals, divided into two sex and age-matched groups: obese (body mass index—BMI≥ 30 kg/m2 ; n= 36) and nonobese (BMI < 30 kg/m2 ; n= 36). The lipidomic profles were evaluated in plasma using 1 H nuclear magnetic resonance (1 H-NMR) spectroscopy. Obese individuals had higher waist circumference (p< 0.001), visceral adiposity index (p= 0.029), homeostatic model assessment insulin resistance (HOMA-IR) (p= 0.010), and triacylglycerols (TAG) levels (p= 0.018). 1 H-NMR analysis identifed higher amounts of saturated lipid metabolite fragments, lower levels of unsaturated lipids, and some phosphatidylcholine species in the obese group. Two powerful machine learning (ML) models—knearest neighbors (kNN) and XGBoost (XGB) were employed to characterize the lipidomic profle of obese individuals. The results revealed metabolic alterations associated with obesity in the NMR signals. The models achieved high accuracy of 86% and 81%, respectively. The feature importance analysis identifed signal at 1.50–1.60 ppm (–CO–CH2–CH2–, Cholesterol and fatty acid in TAG, Phospholipids) to have the highest importance in the two modelsArtigo Selenium in human health and gut microflora: bioavailability of selenocompounds and relationship with diseases(Frontiers in Nutrition, 2021-06) Evangelista, Karine Cavalcanti Maurício de Sena; Ferreira, Rannapaula Lawrynhuk Urbano; Azevedo, Eduardo Pereira de; Pinheiro, Francisco Irochima; Cobucci, Ricardo Ney; Pedrosa, Lucia Fatima CamposThis review covers current knowledge of selenium in the dietary intake, its bioavailability, metabolism, functions, biomarkers, supplementation and toxicity, as well as its relationship with diseases and gut microbiota specifically on the symbiotic relationship between gut microflora and selenium status. Selenium is essential for the maintenance of the immune system, conversion of thyroid hormones, protection against the harmful action of heavy metals and xenobiotics as well as for the reduction of the risk of chronic diseases. Selenium is able to balance the microbial flora avoiding health damage associated with dysbiosis. Experimental studies have shown that inorganic and organic selenocompounds are metabolized to selenomethionine and incorporated by bacteria from the gut microflora, therefore highlighting their role in improving the bioavailability of selenocompounds. Dietary selenium can affect the gut microbial colonization, which in turn influences the host’s selenium status and expression of selenoproteoma. Selenium deficiency may result in a phenotype of gut microbiota that is more susceptible to cancer, thyroid dysfunctions, inflammatory bowel disease, and cardiovascular disorders. Although the host and gut microbiota benefit each other from their symbiotic relationship, they may become competitors if the supply of micronutrients is limited. Intestinal bacteria can remove selenium from the host resulting in two to three times lower levels of host’s selenoproteins under selenium-limiting conditions. There are still gaps in whether these consequences are unfavorable to humans and animals or whether the daily intake of selenium is also adapted to meet the needs of the bacteriaArtigo The beneficial effects of rosuvastatin are independent of zinc supplementation in patients with atherosclerosis(Journal of Trace Elements in Medicine and Biology, 2014-04) Evangelista, Karine Cavalcanti Maurício de Sena; Dias, Paula Cristina Silveira; Paiva, Maria Sanali Moura de Oliveira; Ferreira, Diana Quitéria Cabral; Ururahy, Marcela Abbott Galvão; Rezende, Adriana Augusto; Abdalla, Dulcinéia Saes Parra; Pedrosa, Lucia Fatima CamposBackground: Statins have multiple antiatherosclerotic effects, but can reduce blood plasma concentrations of minerals, including zinc. As zinc possesses antiinflammatory and antioxidant effects, low zinc status can promote injuries or inadequate tissue repair in endothelial cells. Metallothionein (MT) expression might modulate responses induced by statins in patients with atherosclerosis. However, research regarding mineral status and the use of statins is scarce. This study evaluated the effects of zinc supplementation on zinc status and expression of the zinc-dependent MT1F and MT2A genes in patients with atherosclerosis treated with rosuvastatin. Methods: A double-blind, randomized clinical trial was performed with 54 participants treated with 10 mg rosuvastatin for 4 months with or without zinc supplementation (30 mg/day). Diet, lipid profile, high-sensitivity reactive protein C (hs-CRP), plasma and erythrocyte zinc concentrations, erythrocyte superoxide dismutase (SOD) activity, and MT1F and MT2A genes expression were analyzed before and after intervention. Results: Rosuvastatin therapy was effective in reducing low- and non-high-density lipoprotein, total cholesterol, triglycerides, and hs-CRP levels, independent of zinc supplementation. Additionally, zinc treatment had no effect on SOD enzyme activity (P = 0.201), plasma (P > 0.671) and erythrocyte (P > 0.123) zinc concentrations, or the pattern of MT1F and MT2A genes expression (P = 0.088 and P = 0.229, respectively). Conclusions: The effectiveness of rosuvastatin treatment is independent of the effects of zinc supplementation. Moreover, rosuvastatin treatment did not have a significant impact on zinc status or MT1F and MT2A genes expression in patients with atherosclerosisArtigo The hypolipidemic and pleiotropic effects of rosuvastatin are not enhanced by its association with zinc and selenium supplementation in coronary artery disease patients: a double blind randomized controlled study(Plos One, 2015-03) Evangelista, Karine Cavalcanti Maurício Sena; Pedrosa, Lucia Fatima Campos; Paiva, Maria Sanali Moura Oliveira; Dias, Paula Cristina Silveira; Ferreira, Diana Quitéria Cabral; Cozzolino, Sílvia Maria Franciscato; Faulin, Tanize Espírito Santo; Abdalla, Dulcinéia Saes ParraObjective: Statins treatment may modify the levels of zinc and selenium, minerals that can improve vascular function and reduce oxidative damage and inflammation in atherosclerotic patients. This study aimed to evaluate the effects of rosuvastatin, alone or associated with zinc and selenium supplementation, on lipid profile, antioxidant enzymes and mineral status in coronary artery disease patients. Material and Methods A double-blind randomized clinical trial was performed in which patients (n = 76) were treated with 10 mg rosuvastatin over 4 months associated or not with zinc (30 mg/d) and selenium (150 μg/d) supplementation. The following parameters were analyzed before and after the intervention: anthropometric measurements, lipid profile, high sensitivity C-reactive protein (hs-CRP), electronegative low density lipoprotein (LDL(-)) concentrations, activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), zinc and selenium concentrations in blood plasma and erythocytes. Significance was determined using an α of 5% (twotailed). Results We found that rosuvastatin therapy was efficient in reducing total cholesterol, LDL-cholesterol, non-HDL cholesterol, triglycerides, and hs-CRP independently of mineral supplementation. Neither treatment was associated with significant changes in LDL(-). Similarly, the antioxidant enzymes GPx and SOD activity were unchanged by treatments. Neither treatment was associated with significant differences in concentrations of zinc or selenium in blood plasma and erythocytes of studied groups. Conclusion Rosuvastatin treatment did not affect zinc and selenium levels in coronary artery disease patients. The zinc and selenium supplementation at doses used in this study did not change lipid profile or SOD and GPx activity in patients receiving rosuvastatin. Further studies should be focused on testing alternative doses and supplements in different populations to contribute for a consensus on the ideal choice of antioxidants to be used as possible complementary therapies in atherosclerotic patientsArtigo The impact of essential and toxic elements on cardiometabolic risk factors in adults and older people(Journal of trace elements in medicine and biology, 2022) Lima, Severina Carla Vieira Cunha; Nunes, Francisca Leide da Silva; Lyra, Clélia de Oliveira; Marchioni, Dirce Maria; Pedrosa, Lucia Fatima Campos; Barbosa Júnior, Fernando Barbosa; Evangelista, Karine Cavalcanti Maurício Sena; https://orcid.org/0000-0001-8268-1986Background and aim Evidence suggests an association between essential and toxic elements and the worsening of cardiometabolic risk factors. This study aimed to investigate the concentrations of zinc, copper, selenium, arsenic, cadmium, and mercury and their relationship with cardiometabolic risk factors in adults and older people. Methods: This cross-sectional study was carried out with 112 adults with a mean age of 59 (sd 14) years old and a BMI of 29.30 (sd 5.11) Kg/m2. The subject’s weight and height were measured for body mass index (BMI) calculation, classified according to the cut-off points recommended by the World Health Organization (WHO). We evaluated sociodemographic, clinical, lifestyle, waist circumference – WC, visceral adiposity index - VAI, glycemic lipid profile, blood pressure, and high-sensitive C-reactive protein (hs-CRP). Cardiovascular risk was defined by The Global Risk Score (GRS) score. Plasma zinc, selenium, copper levels, urinary arsenic, cadmium, and mercury levels were measured using the inductively coupled plasma mass spectrometry technique (ICP-MS). Results: There was a negative association between urinary arsenic and VAI (β − 0.03, p < 0.01), triglycerides (β − 1.10, p < 0.01), and VLDL cholesterol (β − 0.14, p = 0.02). Plasma copper and copper/zinc ratio were positively associated with fasting glucose and hs-CRP (β 0.38, p < 0.01; β 36.02, p = 0.01, β 0.004, p < 0.01, β 0.68, p < 0.001, respectively). Urinary arsenic (β − 0.14, p = 0.04) and cadmium (β − 36.42, p = 0.04) were negatively associated with systolic blood pressure. Also, urinary cadmium was negatively associated with diastolic blood pressure (β − 21.55, p = 0.03), and urinary mercury showed an opposite behavior (β 1.45, p = 0.03). Conclusion: Essential and toxic elements in urine and plasma could be potential biomarkers for cardiovascular risk factors. A healthy lifestyle should be adopted; in addition, government policies should be developed to guarantee sustainable production and a safe environment.Artigo The impact of essential and toxic elements on cardiometabolic risk factors in adults and older people(Journal of Trace Elements In Medicine and Biology, 2022-06) Lyra, Clelia de Oliveira; Nunes, Francisca Leide da Silva; Lima, Severina Carla Vieira Cunha; Marchioni, Dirce Maria; Pedrosa, Lucia Fatima Campos; Barbosa Júnior, Fernando; Evangelista, Karine Cavalcanti Maurício SenaBackground and aim: Evidence suggests an association between essential and toxic elements and the worsening of cardiometabolic risk factors. This study aimed to investigate the concentrations of zinc, copper, selenium, arsenic, cadmium, and mercury and their relationship with cardiometabolic risk factors in adults and older people. Methods: This cross-sectional study was carried out with 112 adults with a mean age of 59 (sd 14) years old and a BMI of 29.30 (sd 5.11) Kg/m2 . The subject’s weight and height were measured for body mass index (BMI) calculation, classified according to the cut-off points recommended by the World Health Organization (WHO). We evaluated sociodemographic, clinical, lifestyle, waist circumference – WC, visceral adiposity index - VAI, glycemic lipid profile, blood pressure, and high-sensitive C-reactive protein (hs-CRP). Cardiovascular risk was defined by The Global Risk Score (GRS) score. Plasma zinc, selenium, copper levels, urinary arsenic, cadmium, and mercury levels were measured using the inductively coupled plasma mass spectrometry technique (ICP-MS). Results: There was a negative association between urinary arsenic and VAI (β − 0.03, p < 0.01), triglycerides (β − 1.10, p < 0.01), and VLDL cholesterol (β − 0.14, p = 0.02). Plasma copper and copper/zinc ratio were positively associated with fasting glucose and hs-CRP (β 0.38, p < 0.01; β 36.02, p = 0.01, β 0.004, p < 0.01, β 0.68, p < 0.001, respectively). Urinary arsenic (β − 0.14, p = 0.04) and cadmium (β − 36.42, p = 0.04) were negatively associated with systolic blood pressure. Also, urinary cadmium was negatively associated with diastolic blood pressure (β − 21.55, p = 0.03), and urinary mercury showed an opposite behavior (β 1.45, p = 0.03). Conclusion: Essential and toxic elements in urine and plasma could be potential biomarkers for cardiovascular risk factors. A healthy lifestyle should be adopted; in addition, government policies should be developed to guarantee sustainable production and a safe environment