Navegando por Autor "Podestá, José Roberto Vasconcelos de"

Agora exibindo 1 - 1 de 1

Polymorphisms in methylenetetrahydrofolate reductase and cystathionine beta-synthase in oral cancer - a case-control study in southeastern Brazilians
(Elsevier, 2016) Barbosa, Andressa; Santos, Marcelo dos; Podestá, José Roberto Vasconcelos de; Gouvêa, Sônia Alves; Zeidler, Sandra Ventorin Von; Louro, Iúri Drumond; Cordeiro-Silva, Melissa de Freitas
Introduction: Oral squamous cell carcinoma (OSCC) is a serious public health problem, due to its high mortality rate and worldwide rising incidence. OSCC susceptibility is mediated by interactions between genetic and environmental factors. Studies suggest that genetic variants encoding enzymes involved in folate metabolism may modulate OSCC risk by altering DNA synthesis/repair and methylation process. Objective: The goals of this study were to evaluate the association of three genotypic polymorphism (MTHFR C677T, MTHFR A1298C and CBS 844ins68) and oral cancer risk in southeastern Brazilians and evaluate the interactions between polymorphisms and clinical histopathological parameters. Methods: This case-control study included 101 cases and 102 controls in the state of Espírito Santo, Brazil. MTHFR genotyping was done by PCR-RFLP (polymerase chain reaction --- restriction fragment length polymorphism) and CBS genotyping by PCR (polymerase chain reaction) analysis

SIGAA