Navegando por Autor "Prado, Carla M."
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Artigo Comparative assessment of abdominal and thigh muscle characteristics using CT-derived images(Nutrition, 2022-07) Fayh, Ana Paula Trussardi; Medeiros, Galtieri Otávio Cunha de; Sousa, Iasmin Matias de; Chaves, Gabriela Villaça; Gonzalez, Maria Cristina; Prado, Carla M.Objectives: The aim of this study was to compare the assessment of skeletal muscle area (SMA in cm2 ), skeletal muscle index (SMI in cm2 /m2 ), and skeletal muscle density (SMD in HU) between third lumbar vertebra (L3) and thigh landmarks, and the agreement in diagnosing low muscle mass and low SMD (L3 as the reference method). Methods: This was a multicenter, cross-sectional study including healthy individuals (18 y of age) of both sexes, who had an elective computed tomography exam including abdominal and pelvic regions. Computed tomography images were analyzed to evaluate SMA, SMI, and SMD. Muscle abnormalities (low SMA, SMI, and SMD) were defined as values below the fifth percentile from a subsample of healthy young individuals (n = 111; 1839 y of age; 55.9% women). Correlation coefficients, BlandAltman graphs, and receiver operating characteristic (ROC) curves were calculated for the total sample and stratified by sex and age. Results: In all, 268 individuals (44.3 § 15.2 y of age) were evaluated (53% women). Significant (P < 0.001 for all analysis) and strong correlations between SMA (r = 0.896), SMI (r= 0.853), and SMD (r= 0.864) compared with L3 and thigh landmarks were observed. For the ROC curves, similar areas under the curve values were obtained for men (0.981), women (0.895), younger (0.902), and older adults (0.894). Conclusions: Muscle characteristics between L3and thigh landmarks have a strong correlation. This suggests that images of the thigh can be used to characterize muscle characteristics. Image acquisition and analysis of thigh region is simpler, with less radiation exposure, and consequently more appropriate for longitudinal analysisArtigo Low calf circumference adjusted for body mass index is associated with prolonged hospital stay(The American Journal Of Clinical Nutrition, 2023-02) Fayh, Ana Paula Trussardi; Sousa, Iasmin Matias de; Lima, Júlia; Gonzalez, Maria Cristina; Prado, Carla M.; Silva, Flávia MoraesBackground: Calf circumference (CC) is of emerging importance because of its practicality, high correlation with skeletal muscle, and potential predictive value for adverse outcomes. However, the accuracy of CC is influenced by adiposity. CC adjusted for BMI (BMI-adjusted CC) has been proposed to counteract this problem. However, its accuracy to predict outcomes is unknown. Objectives: To evaluate the predictive validity of BMI-adjusted CC in hospital settings. Methods: A secondary analysis of a prospective cohort study in hospitalized adult patients was conducted. The CC was adjusted for BMI by reducing 3, 7, or 12 cm for BMI (in kg/m2) of 25–29.9, 30–39.9, and ≥40, respectively. Low CC was defined as ≤34 cm for males and ≤33 cm for females. Primary outcomes included length of hospital stay (LOS) and in-hospital death, and secondary outcomes were hospital readmissions and mortality within 6 mo after discharge. Results: We included 554 patients (55.2 ± 14.9 y, 52.9% men). Among them, 25.3% presented with low CC, whereas 60.6% had BMI-adjusted low CC. In-hospital death occurred in 13 patients (2.3%), and median LOS was 10.0 (5.0–18.0) d. Within 6 mo from discharge, 43 patients (8.2%) died, and 178 (34.0%) were readmitted to the hospital. BMI-adjusted low CC was an independent predictor of LOS ≥ 10 d (odds ratio = 1.70; 95% confidence interval: 1.18, 2.43], but it was not associated with the other outcomes. Conclusions: BMI-adjusted low CC was identified in more than 60% of hospitalized patients and was an independent predictor of longer LOS