Navegando por Autor "Reis, Amilcar"
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Artigo NEIL3 influences adult neurogenesis and behavioral pattern separation via WNT signaling(Springer Science and Business Media LLC, 2025-03) Fernandez-Berrocal, Marion S.; Reis, Amilcar; Rolseth, Veslemøy; Suganthan, Rajikala; Kuśnierczyk, Anna; França, Arthur; Soares, Annara Yve Moura; Kunath, Nicolas; Bugaj, Anna M.; Abentung, Andreas; Eide, Lars; Leao, Richardson Naves; Bjørås, Magnar; Scheffler, Katja; Ye, JingAdult neurogenesis in the hippocampus, involving the generation and integration of new neurons, is essential for behavioral pattern separation, which supports accurate memory recall and cognitive plasticity. Here, we explore the role of the DNA repair protein NEIL3 in adult hippocampal neurogenesis and behavioral pattern separation. NEIL3 is required for efficient proliferation and neuronal differentiation of neonatal NSPCs and adult-born NPCs in the hippocampus following a behavioral pattern separation task. NEIL3-depleted mice exhibited a reduced preference for the novel object location, indicating a deficit in pattern separation. NEIL3-deficient adult-born neurons exhibited a significant reduction in mature-like membrane properties, indicating impaired functional maturation. Interestingly, these impairments were not associated with the decreased genomic integrity but with the altered transcriptional regulation of the Wnt signaling pathway. Given the importance of adult neurogenesis in cognitive function, targeting NEIL3 could offer therapeutic potential for addressing age-related hippocampal dysfunction and cognitive declineArtigo OLMα2 cells bidirectionally modulate learning(2018-07) Siwani, Samer; França, Arthur S. C.; Mikulovic, Sanja; Reis, Amilcar; Hilscher, Markus M.; Edwards, Steven J.; Leão, Richardson Naves; Tort, Adriano Bretanha Lopes; Kullander, KlasInhibitory interneurons participate in mnemonic processes. However, defined roles for identified interneuron populations are scarce. A subpopulation of oriens lacunosum-moleculare (OLM) interneurons genetically defined by the expression of the nicotinic receptor α2 subunit has been shown to gate information carried by either the temporoammonic pathway or Schaffer collaterals in vitro. Here we set out to determine whether selective modulation of OLMα2 cells in the intermediate CA1 affects learning and memory in vivo. Our data show that intermediate OLMα2 cells can either enhance (upon their inhibition) or impair (upon their activation) object memory encoding in freely moving mice, thus exerting bidirectional control. Moreover, we find that OLMα2 cell activation inhibits fear-related memories and that OLMα2 cells respond differently to nicotine in the dorsoventral axis. These results suggest that intermediate OLMα2 cells are an important component in the CA1 microcircuit regulating learning and memory processes.