Navegando por Autor "Restrepo, Carlos Ernesto"

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Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor
(2018-09) Mikulovic, Sanja; Restrepo, Carlos Ernesto; Siwani, Samer; Bauer, Pavol; Pupe, Stefano; Tort, Adriano Bretanha Lopes; Kullander, Klas; Leão, Richardson Naves
Dorsal and ventral hippocampus regions exert cognition and emotion-related functions, respectively. Since both regions display rhythmic activity, specific neural oscillatory pacemakers may underlie their functional dichotomy. Type 1 theta oscillations are independent of cholinergic transmission and are observed in the dorsal hippocampus during movement and exploration. In contrast, type 2 theta depends on acetylcholine and appears when animals are exposed to emotionally laden contexts such as a predator presence. Despite its involvement in emotions, type 2 theta has not been associated with the ventral hippocampus. Here, we show that optogenetic activation of oriens-lacunosum moleculare (OLM) interneurons in the ventral hippocampus drives type 2 theta. Moreover, we found that type 2 theta generation is associated with increased risk-taking behavior in response to predator odor. These results demonstrate that two theta oscillations subtypes originate in the two hippocampal regions that predominantly underlie either cognitive or emotion-related functions.

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