Navegando por Autor "Ribeiro, Heriks Gomes"
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TCC mirSNPs as potential colorectal cancer biomarkers: a systematic review(Universidade Federal do Rio Grande do Norte, 2024-12-18) Santos, Katiusse Alves dos; Silbiger, Vivian Nogueira; Dantas-Komatsu, Raquel Costa Silva; Ribeiro, Heriks Gomes; Rosa Neta, Antonia PereiraColorectal cancer (CRC) is the third most common neoplasm in the world and the second with the highest mortality rate. Single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes known as mirSNPs may be related to dysregulated miRNA expression in several neoplasms. This systematic review aims to investigate studies that investigate SNPs located in regions of miRNA genes that influence their expression and are associated with CRC, as well as their potential as biomarkers for the disease, based on the available literature. For this, searches were performed in public databases, including MEDLINE/PubMed, Embase, Web of Science, and Scopus. The rigorous review of the PRISMA 2020 guidelines and the methodological quality of these studies was assessed using the Newcastle–Ottawa scale and the Mixed Methods Assessment Tool. Of the 175 studies identified, 26 were considered eligible: 18 of them highlighted mirSNPs as potential biomarkers of risk and prognosis for CRC; 4 studies suggested a protective role; 1 study linked mirSNPs to treatment; 3 studies found no relevant evidence. These results highlight the importance of conducting further research on the topic, given the potential of these biomarkers to contribute to risk assessment, prognosis, and the development of therapeutic strategies for patients with CRCDissertação O papel dos miRNAs como biomarcadores na cardiomiopatia chagásica: uma revisão da literatura e análise in silico(Universidade Federal do Rio Grande do Norte, 2024-02-20) Ribeiro, Heriks Gomes; Silbiger, Vivian Nogueira; https://orcid.org/0000-0002-9252-0278; http://lattes.cnpq.br/6121935907512568; https://orcid.org/0000-0002-7942-2841; http://lattes.cnpq.br/3818231033391380; Santos, Isabelle Cristina Clemente dos; Estanislau, Juliana de Assis Silva GomesIntrodução: A cardiomiopatia chagásica (CC) é uma forma grave da doença de Chagas (DC) e uma das principais causas de morbidade e mortalidade cardiovascular. A desregulação da resposta imune leva à remodelação cardíaca e alterações funcionais, resultando em complicações com risco de vida. Os métodos diagnósticos convencionais possuem limitações e a avaliação da resposta terapêutica ainda é um desafio. MicroRNAs (miRNAs), importantes reguladores da expressão gênica, apresentam potencial como biomarcadores para diagnóstico e prognóstico. Objetivo: Esta revisão visa resumir os achados experimentais sobre a expressão de diferencial de miRNAs na CC e explorar o potencial desses miRNAs como biomarcadores na doença de Chagas. Métodos: A busca foi realizada no banco de dados público da Biblioteca Nacional de Medicina dos Estados Unidos (MEDLINE/PubMed) usando os termos “Chagas cardiomyopathy” OR “Chagas disease” AND “microRNA” OR “miRNA” OR “miR”. Além disso, uma análise de bioinformática foi realizada para investigar as interações miRNA-alvo e explorar vias de enriquecimento por Ontologia Gênica (GO) de processos biológicos e funções moleculares. Resultados: O miR-21, miR-146b, miR-146a e miR-155 exibiram consistentemente regulação positiva, enquanto o miR-145 foi regulado negativamente na CC. Esses miRNAs específicos têm sido associados à fibrose, resposta imune e processos inflamatórios no tecido cardíaco. Conclusão: Nesta revisão, destacamos o papel dos miRNAs frequentes nos estudos analisados. Além da apresentação das funções biológicas no contexto CC, esses miRNAs mostraramse potenciais biomarcadores para diagnóstico, progressão da doença e monitoramento do tratamento antiparasitário.Artigo Previous vitamin D status and total cholesterol are associated with SARS-CoV-2 infection(Clinica Chimica Act, 2021-11) Reis, Bruna Zavarize; Ribeiro, Heriks Gomes; Komatsu, Raquel Costa Silva Dantas; Medeiros, Jeane Franco Pires; Carvalho, Maria Clara da Cruz; Soares, Victor de Lima; Luchessi, André Ducati; Silbiger, Vivian NogueiraBackground: The relationship of vitamin D status and other biochemical parameters with the risk of SARS-CoV-2 infection remains inconclusive, especially in regions with high solar incidence. Therefore, we aimed to associate the 25-hydroxyvitamin D (25(OH)D) concentrations and lipid profile prior to the SARS-CoV-2 tests in a population from a sunny region in Brazil (5 degrees S, 35 degrees W). Methods: This retrospective cohort study enrolled 1634 patients tested for SARS-CoV-2 of a private medical laboratory with 25(OH)D concentration and lipid profile measured ≥ 7 days before the date of the first SARSCoV-2 RT-PCR test and were categorized according to 25(OH)D sufficiency (≥30 ng/mL) or insufficiency (<30 ng/mL). Multiple logistic regression analyses were performed to assess risk factors associated with positive tests for SARS-CoV-2. Results: Average serum 25(OH)D was 33.6 ng/mL. Vitamin D deficiency (<20 ng/mL) was only found in 2.6% of the participants. Multivariate analysis demonstrated that patients > 49 y with insufficient 25(OH)D (<30 ng/mL) presented increased odds to test positive for SARS-CoV-2 (OR: 2.02, 95 %CI: 1.15 to 3.55, P = 0.015). The same is observed among those with total cholesterol > 190 mg/dL (OR: 1.90, 95 %CI: 1.10 to 3.28, P = 0.020). Conclusions: Previous insufficient 25(OH)D (<30 ng/mL) concentration and high total cholesterol were associated with SARS-CoV-2 infection among adults > 48 y in the study population. Further studies should be conducted to confirm whether measurement of 25(OH)D and lipid profile could be useful to identify patients who are more susceptible to COVID-19TCC Previous vitamin D status and total cholesterol are associated with SARS-CoV-2 infection(Universidade Federal do Rio Grande do Norte, 2021-08-20) Ribeiro, Heriks Gomes; Silbiger, Vivian Nogueira; Victor de Lima Soares; Rebecchi, Ivanise Marina Moretti; Miranda, Carolinne Thaísa de Oliveira FernandesBackground and Aims: The relationship of vitamin D status and other biochemical parameters with the risk of SARS-CoV-2 infection remains inconclusive, especially in regions with high solar incidence. Therefore, we aimed to associate the 25-hydroxyvitamin D (25(OH)D) levels and lipid profile prior to the SARS-CoV-2 tests in a population from a sunny region in Brazil (5° S, 35° W). Methods and Results: This is a retrospective cohort study which enrolled 1634 patients tested for SARS-CoV-2 of a private medical laboratory with 25(OH)D level and lipid profile measured seven or more days before the date of the first SARS-CoV-2 RT-PCR test and were categorized according to 25(OH)D sufficiency (≥ 30 ng/ml) or insufficiency (< 30 ng/mL). Multiple logistic regression analyses were performed to assess risk factors associated with positive tests for SARS-CoV-2. Average serum 25(OH)D was 33.6 ng/mL. The vitamin D deficiency (< 20 ng/mL) reached only 2.6% of the participants. Multivariate analysis demonstrated that patients > 49 years old with insufficient 25(OH)D (< 30 ng/mL) presented increased odds to test positive for SARS-CoV-2 (OR: 2.02, 95%CI: 1.15 to 3.55, P = 0.015). The same is observed among those with Total Cholesterol > 190 mg/dL (OR: 1.90, 95%CI: 1.10 to 3.28, P = 0.020). Conclusions: Previous insufficient 25(OH)D (< 30 ng/mL) concentration and high total cholesterol were associated with SARS-CoV-2 infection among adults older than 49 years in the study population. Further studies should be conducted to confirm whether measurement of 25(OH)D and lipid profile could be useful to identify patients who are more susceptible to COVID-19.