Navegando por Autor "Silva Neto, Antônio Braz"
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Artigo Association of BDNF Val66MET polymorphism with parkinson’s disease and depression and anxiety symptoms(Psychiatry Online, 2016-11-17) Godeiro Junior, Clécio de Oliveira; Cagni, Fernanda Carvalho; Campêlo, Clarissa Loureiro das Chagas; Coimbra, Daniel Gomes; Barbosa, Mayara Rodrigues; Oliveira Júnior, Luiz Gonzaga; Silva Neto, Antônio Braz; Ribeiro, Alessandra Mussi; Andrade, Tiago Gomes de; Silva, Regina Helena; 0000-0002-4312-1633Parkinson’s disease (PD) is a progressive neurodegenerative disease that affects mainly dopaminergic neurons of the substantia nigra pars compacta (SNpc), leading to motor symptoms (tremor, bradykinesia, rigidity, and postural instability). PD also presents nonmotor symptoms, such as cognitive impairments and emotional disturbances (depression and anxiety). Although the direct cause is unknown, PD is a multifactorial disease influenced by environmental and genetic factors, with aging being the core predisposing factor.Artigo Variants in SNCA gene are associated with parkinson’s disease risk and cognitive symptoms in a brazilian sample(Frontiers in Aging Neuroscience, 2017-06-20) Godeiro Junior, Clecio de Oliveira; Campêlo, Clarissa Loureiro das Chagas; Cagni, Fernanda Carvalho; Figueredo, Diego de Siqueira; Oliveira Junior, Luiz Gonzaga; Silva Neto, Antônio Braz; Macêdo, Priscila T.; Santos, José R.; Izídio, Geison Souza; Ribeiro, Alessandra Mussi; Andrade, Tiago Gomes de; Silva, Regina Helena; 0000-0002-4312-1633Genetic susceptibility contributes to the etiology of sporadic Parkinson’s Disease (PD) and worldwide studies have found positive associations of polymorphisms in the alphasynuclein gene (SNCA) with the risk for PD. However, little is known about the influence of variants of SNCA in individual traits or phenotypical aspects of PD. Further, there is a lack of studies with Latin-American samples. We evaluated the association between SNCA single nucleotide polymorphisms (single nucleotide polymorphisms, SNPs –rs2583988, rs356219, rs2736990, and rs11931074) and PD risk in a Brazilians sample. In addition, we investigated their potential interactions with environmental factors and specific clinical outcomes (motor and cognitive impairments, depression, and anxiety). A total of 105 PD patients and 101 controls participated in the study. Single locus analysis showed that the risk allele of all SNPs were more frequent in PD patients (p < 0.05), and the associations of SNPs rs2583988, rs356219, and rs2736990 with increased PD risk were confirmed. Further, the G-rs356219 and C-rs2736990 alleles were associated with early onset PD. T-rs2583988, G-rs356219 and C-2736990 alleles were significantly more frequent in PD patients with cognitive impairments than controls in this condition. In addition, in a logistic regression model, we found an association of cognitive impairment with PD, and the practice of cognitive activity and smoking habits had a protective effect. This study shows for the first time an association of SNCA polymorphism and PD in a South-American sample. In addition, we found an interaction between SNP rs356219 and a specific clinical outcome, i.e., the increased risk for cognitive impairment in PD patients.