Navegando por Autor "Waitzberg, Dan Linetzky"
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Artigo The relationship of the oleic acid level and ECHDC3 mRNA expression with the extent of coronary lesion(Lipids in Health and Disease, 2016) Lima, Severina Carla Vieira Cunha; Duarte, Mychelle Kytchia Rodrigues Nunes; Araújo, Jéssica Nayara Góes de; Duarte, Victor Hugo Rezende; Oliveira, Katiene Macêdo de; Oliveira, Juliana Marinho de; Carioca, Antonio Augusto Ferreira; Bortolin, Raul Hernandes; Rezende, Adriana Augusto; Hirata, Mario Hiroyuki; Hirata, Rosário Domingues; Waitzberg, Dan Linetzky; Luchessi, André Ducati; Silbiger, Vivian Nogueira; https://orcid.org/0000-0001-8268-1986Background: The fatty acid profile is associated with the risk and progression of several diseases, probably via mechanisms including its influence on gene expression. We previously reported a correlation between ECHDC3 upregulation and the severity of acute coronary syndrome. Here, we assessed the relationship of serum fatty acid profile and ECHDC3 expression with the extent of coronary lesion. Methods: Fifty-nine individuals aged 30 to 74 years and undergoing elective cinecoronariography for the first time were enrolled in the present study. The extent of coronary lesion was assessed by the Friesinger index and patients were classified as without lesion (n = 18), low lesion (n = 17), intermediate lesion (n = 17) and major lesion (n = 7). Serum biochemistry, fatty acid concentration, and ECHDC3 mRNA expression in blood were evaluated. Results: Elevated serum levels of oleic acid and total monounsaturated fatty acids were observed in patients with low and intermediate lesion, when compared to patients without lesion (p < 0.05). ECHDC3 mRNA expression was 1. 2 fold higher in patients with low lesion than in patients without lesion (p = 0.020), and 1.8 fold lower in patients with major lesion patients than in patients with low lesion (p = 0.023). Conclusion: Increased levels of monounsaturated fatty acids, especially oleic acid, and ECHDC3 upregulation in patients with coronary artery lesion suggests that these are independent factors associated with the initial progression of cardiovascular disease.