CCS - DTG - Artigos publicados em periódicos
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Article Pharmacological treatment of antidepressant-induced sexual dysfunction in women: a systematic review and meta-analysis of randomized clinical trials(Clinics, 2025-02-21) Aquino, Antonio Carlos Queiroz de; Sarmento, Ayane Cristine; Teixeira, Raphaell Lucas de Araújo; Batista, Tâmilly Nascimento; Freitas, Cijara Leonice de; Mármol, José Manuel Pérez; Lara, Lucia Alves Silva; Gonçalves, Ana Katherine; https://orcid.org/0000-0002-1464-243X; https://orcid.org/0000-0001-9131-1952; https://orcid.org/0009-0006-5272-044X; https://orcid.org/0009-0005-8726-1928; https://orcid.org/0000-0002-9959-0252; https://orcid.org/0000-0001-6489-8268; https://orcid.org/0000-0002-8351-5119Article Non-pharmacologic therapies for treating sexual dysfunction during pregnancy: a systematic review and meta-analysis(International Journal of Gynecology & Obstetrics Early View, 2025-08-27) Aquino, Antonio Carlos Queiroz de; Sarmento, Ayane Cristine Alves; Simões, Ana Carolina Zimmermann; Medeiros, Heitor Dutra de Medeiros; Siqueira, Beatriz Bomtempo de; Nascimento, Tâmilly Batista; Freitas, Cijara Leonice de; Falsetta, Megan; Oliveira, Ana Katherine da Silveira Gonçalves de; https://orcid.org/0000-0002-1464-243X; https://orcid.org/0000-0001-9131-1952; https://orcid.org/0000-0002-2296-2484; https://orcid.org/0000-0001-6341-3791; https://orcid.org/0000-0002-8351-5119Article Treatment interventions for usual-type vulvar intraepithelial neoplasia: a systematic review and meta-analysis(Journal of Lower Genital Tract Disease, 2025-10) Pereira, Ana Carolina Simões Pereira; Sarmento, Ayane Cristine; Aquino, Antonio Carlos; Eleutério Júnior, José; Guimarães, isabel; Falsetta, Megan; Oliveira, Ana Katherine da Silveira Gonçalves de; https://orcid.org/0000-0001-6075-665X; https://orcid.org/0000-0001-9131-1952; https://orcid.org/0000-0002-1223-1151; https://orcid.org/0000-0003-4617-7269; https://orcid.org/0000-0002-9885-2724; https://orcid.org/0000-0001-6341-3791; https://orcid.org/0000-0002-8351-5119Article Genetic association between microRNA gene polymorphisms and polycystic ovary syndrome susceptibility: a systematic review and meta-analysis(International Journal of Gynecology & Obstetrics, 2025-10-25) Souza, Amaxsell Thiago Barros de; Torres, Ketelly Leônara da Silva; Sarmento, Ayane Cristine Alves; Lima, Ariadne Sarynne Barbosa de; Medeiros, Kleyton Santos de; Dantas, Deyse de Souza; Cobucci, Ricardo Ney; Gonçalves, Ana Katherine; Crispim, Janaina Cristiana de Oliveira; https://orcid.org/0000-0002-7085-8788; https://orcid.org/0009-0007-0249-3354; https://orcid.org/0000-0001-9131-1952; https://orcid.org/0000-0001-5920-3388; https://orcid.org/0000-0002-4105-7535; https://orcid.org/0000-0002-8284-0999; https://orcid.org/0000-0002-0184-2061; https://orcid.org/0000-0002-8351-5119; https://orcid.org/0000-0002-1344-0078Article Laser and radiofrequency for treating genitourinary syndrome of menopause in breast cancer survivors: a systematic review of randomized controlled trial(International Journal of Gynecology & Obstetrics, 2025-11-01) Serquiz, Nicoli; Sarmento, Ayane Cristine Alves; Aquino, Antonio Carlos Queiroz de; Almeida, Natalie Rios; Nobre, Maria Luísa; Camargo, Juliana Dantas de Araújo Santos; Medeiros, Kleyton Santos de; Gonçalves, Ana Katherine; https://orcid.org/0000-0003-0276-6061; https://orcid.org/0000-0001-9131-1952; https://orcid.org/0000-0002-1464-243X; https://orcid.org/0000-0003-1372-9258; https://orcid.org/0000-0003-0969-4806; https://orcid.org/0000-0001-8692-5706; https://orcid.org/0000-0002-4105-7535; https://orcid.org/0000-0002-8351-5119Article Effect of glucose on pain relief during invasive procedures in premature infants: systematic review and meta-analysis of randomized controlled trials(Journal of Perinatology, 2025-11-05) Souza, Amaxsell Thiago Barros de; Dantas, Hugo Guilherme da Câmara; Oliveira, Débora Joyce Duarte de; Sarmento, Ayane Cristine Alves; Medeiros, Kleyton Santos de; Oliveira, Ana Katherine da Silveira Gonçalves de; Crispim, Janaina Cristiana de Oliveira; Silva, Maria de Lourdes Costa da; https://orcid.org/0000-0002-7085-8788; https://orcid.org/0009-0001-8736-2025; https://orcid.org/0000-0001-9131-1952; https://orcid.org/0000-0002-4105-7535; https://orcid.org/0000-0002-8351-5119; https://orcid.org/0000-0002-1344-0078; https://orcid.org/0000-0001-7251-8966Article Efficacy and safety of fractional microablative radiofrequency versus topical estriol in treating genitourinary syndrome of menopause: a pilot study(International Journal of Gynecology & Obstetrics, 2025-06-08) Torre, Priscila de Almeida; Fialho, Susana Cristina Aidé Viviani; Guimarães, Isabel Cristina Chulvis do Val; Zunino, Ana Ximena; Castro, Tuani; Martins, Caroline Alves de Oliveira; Oliveira, Ana Katherine da Silveira Gonçalves de; https://orcid.org/0000-0001-8350-5693; https://orcid.org/0000-0002-4212-0022; https://orcid.org/0000-0002-9885-2724; https://orcid.org/0000-0002-8282-4200; https://orcid.org/0009-0009-1303-2515; https://orcid.org/0000-0002-8351-5119Article Is rituximab effective for systemic sclerosis? A systematic review and meta-analysis(Springer, 2021) Piuvezam, Grasiela; Caldas, Marina Maria Vieira de Figueiredo; Azevedo, Kesley Pablo Morais de; Nunes, Ana Clara de França; Oliveira, Victor Hugo de; Pimenta, Isac Davidson Santiago Fernandes; Araújo, Isabela Dantas Torres de; Bezerra Neto, Francisco Alves; Oliveira, Ana Katherine da Silveira Gonçalves de; https://orcid.org/0000-0002-2343-7251Article Associations of the consumption of unprocessed red meat and processed meat with the incidence of cardiovascular disease and mortality, and the dose-response relationship: a systematic review and meta-analysis of cohort studies(Taylor and Francis, 2022) Piuvezam, Grasiela; Medeiros, Gidyenne Christine Bandeira Silva de; Mesquita, Gabriela Xavier Barbalho; Lima, Severina Carla Vieira Cunha; Silva, David Franciole de Oliveira; Azevedo, Kesley Pablo Morais de; Pimenta, isac Davidson Santiago Fernandes; Oliveira, Ana Katherine da Silveira Gonçalves de; Lyra, Clélia de Oliveira; Martínez, Daniel Guillén; https://orcid.org/0000-0002-2343-7251Article Correlation between bacterial vaginosis and adverse obstetric outcomes in Brazilian women(Universidade Federal Fluminense, 2017) Monteiro, Michelly Nóbrega; Cobucci, Ricardo Ney Oliveira; Queiroz, Janice; Lucena, Eudes Euler de Souza; Vital, Ana Luísa Fernandes; Palitot, Tatyane Ribeiro de Castro; Eleutério Junior, José; Giraldo, Paulo César; Oliveira, Ana Katherine da Silveira Gonçalves deIntrodução: Infecções vaginais e mudanças na flora vaginal são prevalentes durante a gravidez e têm sido associadas com desfechos obstétricos adversos, tais como trabalho de parto prematuro, amniorrexe prematura e baixo peso ao nascer. Objetivos: Correlacionar a presença de vaginose bacteriana (VB) com desfecho obstétrico desfavorável em mulheres brasileiras com gravidez no terceiro trimestre. Métodos: O estudo prospectivo observacional foi conduzido avaliando microbiota vaginal por bacterioscopia (a fresco e Gram) usando swab vaginal obtido de mulheres grávidas entre a 26 e a 32a semanas de gestação. As mulheres foram monitoradas até o parto, e os dados de seu seguimento e os demográficos foram coletados por meio de um questionário autoaplicável. Resultados: Foi diagnosticada VB, com base nos critérios de Amsel e de Nugent, em 77 mulheres entre as 190, demonstrando prevalência de 42.5%. VB foi significativamente associada com maior risco de parto prematuro (risk ratio [RR], 2.89; 95% intervalo de confiança [IC], 2.35–3.56) e de baixo peso ao nascer (RR, 2.17; 95%IC, 1.61–2.92). A rotura prematura das membranas não foi associada com VB. Conclusão: Foi constatada alta frequência de VB entre as mulheres brasileiras grávidas no terceiro trimestre, e a BV correlacionou-se com piores prognósticos da gravidez. O rastreio rotineiro de mulheres grávidas pode permitir um tratamento precoce e a prevenção de algumas complicações obstétricasArticle Prevalence of sexual dysfunction among expectant women(Federação das Associações Brasileiras de Ginecologia e Obstetrícia (Febrasgo), 2016-12-22) Monteiro, Michelly Nóbrega; Lucena, Eudes Euler de Souza; Cabral, Patricia Uchoa; Queiroz Filho, José; Queiroz, Janice; Oliveira, Ana Katherine da Silveira Goncalves deObjetivo Identificar a gravidez como fator causador de disfunção sexual entre mulheres gestantes. Métodos Estudo prospectivo com 225 gestantes atendidas no ambulatório de pré-natal de uma universidade federal. A função sexual foi avaliada por meio do Female Sexual Function Index (FSFI), e todos os domínios foram analisados (desejo, excitação, lubrificação, orgasmo, satisfação e dor). Inicialmente, uma análise univariada da amostra foi feita. As médias para cada domínio de acordo com o risco de disfunção sexual (FSFI ≤ 26,5) foram comparadas pelo teste t de Student para amostras independentes. A força da correlação entre a disfunção sexual e todas as variáveis sociodemográficas, clínicas e comportamentais foi medida pelo teste do qui-quadrado (X2). A partir desta perspectiva, foram aferidos os odds ratios (ORs) e seus respectivos intervalos de confiança para a análise bivariada. Quaisquer valores de p inferiores a 0,05 foram considerados significativos. Resultados Cerca de dois terços das mulheres (66,7%) mostraram sinais de risco de disfunção sexual (FSFI ≤ 26,5). Dentro destes casos, todos os domínios de disfunção sexual (desejo, excitação, lubrificação, orgasmo, satisfação e dor) foram estatisticamente significativos (p < 0,001). Os domínios mais afetados foram o desejo (2,67), a satisfação (2,71) e a excitação (2,78). Conclusões A gravidez parece ser um importante fator causador de disfunção sexual entre mulheres gestantesArticle Impacto da inserção da temática saúde sexual e reprodutiva na graduação de Medicina(Thieme Open, 2014-03) Medeiros, Robinson Dias de; Azevedo, George Dantas de; Maranhão, Técia Maria de Oliveira; Oliveira, Ana Katherine da Silveira Goncalves de; Barros, Yasha Emerenciano; Araújo, Ana Cristina Pinheiro Fernandes de; Lima, Stênia Lins LeãoPurpose: to evaluate the impact of sexual and reproductive health theme insertion in the undergraduate medical curriculum at a Brazilian public university. Methods: we developed an instrument for cognitive assessment in sexual and reproductive health based on the subjects addressed in the optional curriculum component Reproductive Health, resulting in an objective multiple choice test containing 27 items. The selected topics were: human, sexual and reproductive rights (HSRR), sexuality, institutional violence, gender, sexual violence, conception, contraception, abortion/legal interruption of pregnancy, maternal mortality and sexually transmitted infections (STIs) – HIV/AIDS. The subjects were grouped into three dimensions of knowledge: HSRR, legal/institutional and biomedical. Two multivariate models were adjusted in the analysis of covariance. Results: the study included 183 students, 127 of the group who took the elective curriculum course reproductive health (RH Group) and 56 who did not (Non-RH Group). Ninety-six students (52.5%) were males and 87 (47.5%) were females. Mean age was 24.7±1.9 years for the RH Group and 24.4±2.6 for the Non-RH Group. The average performance of the SR Group was higher than that of Non-RH subjects regarding the following subjects: HSRR, sexuality, institutional violence, sexual violence, abortion/legal interruption, and STDs – HIV/AIDS. There was no gender difference in performance, except for the theme maternal mortality, in which males scored worse than females (6.9±0.2 and 7.8±0.2, respectively; p<0.05). Conclusions: the participation of students in the elective curriculum component Reproductive Health was associated with better performance in some dimensions of cognitive assessment, suggesting a positive impact of this initiative on general medical educationArticle Mulheres com risco cardiovascular após pré-eclâmpsia: há seguimento no Sistema Único de Saúde?(Universidade de São Paulo (USP), 2014-01) Silva, Maria de Lourdes Costa da; Galvão, Ana Cristina Araújo de Andrade; Souza, Nilba Lima de; Azevedo, George Dantas de; Jerônimo, Selma Maria Bezerra; Araújo, Ana Cristina Pinheiro Fernandes deObjectives: to identify women with cardiovascular risk, five years after a preeclampsic episode (PE), and identify the follow-up of these women within the Unified Health System (Sistema Único de Saúde – SUS), in the city of Natal/RN. Methods: a quantitative and exploratory study conducted at the Januário Cicco University Maternity Ward/RN. The sample consisted of 130 women, 65 with a PE episode and 65 who were normotensive. Results: we found statistical significance with regard to body mass index, weight, family history of cardiovascular disease (CVD) and cardiovascular complications when comparing women with previous PE to normotensive women. The groups were unaware of their cardiovascular risk factors and, in addition, they reported difficulties in accessing primary health care (PHC) services. Conclusions: women with a PE history are at increased risk of developing CVD, unaware of late PE complications, and lacked customized care when compared to normotensive patientsArticle An innovative educational strategy to addressing cultural competence in healthcare for quilombola women(Taylor and Francis, 2019) Freitas Junior, Reginaldo Antonio de Oliveira; Santos, Carolina Araujo Damasio; Lisboa, Lilian Lira; Freitas, Ana Karla Monteiro Santana de Oliveira; Azevedo, George Dantas deArticle Clustering of risk factors for cardiometabolic diseases in low-income, female adolescents(Sociedade Brasileira de Endocrinologia e Metabologia, 2016-06) Melo, Elza Maria Fernandes Seabra de; Azevedo, George Dantas de; Silva, João Batista da; Lemos, Telma Maria Araujo Moura; Maranhão, Técia M. O.; Freitas, Ana Karla Monteiro Santana de Oliveira; Spyrides, Maria H.; Costa, Eduardo CaldasArticle Mapeamento do fluxo das gestantes de alto risco do pré-natal da Maternidade Escola Januário Cicco – MEJC(Revista Brasileira de Inovação Tecnológica em Saúde, 2016-08-17) Câmara, Hugo Estevam de Sales; Hékis, Hélio Roberto; Araújo, Bruno Gomes de; Cornetta, Maria da Conceição de Mesquita; Farias, Daniel José LeiteArticle Project Pró-Natal: population-based study of perinatal and infant mortality in Natal, Northeast Brazil(2000) Ramos, Ana Maria Oliveira; Maranhão, Técia Maria de Oliveira; Macedo, Albanita Leite Soares de; Pollock, Jon I.; Emond, AlanThe Pró-Natal project is a collaborative initiative that aims to improve maternal and infant health in a deprived community in Natal, Northeast Brazil. To assess the perinatal and infant mortality in this population of 40,000, we have collected over a 2-year period a consecutive series of 39 autopsy examinations on deaths under 1 year of age. During this period there were 2212 live births in the study population. The 14 perinatal deaths are described using theWrigglesworth classification, and the 25 infant deaths, using a clinicopathological system. The contribution of normally formed stillbirths was small (14%), which probably reflects the underreporting of stillbirths in this community. The most common cause of death in the live births was complications of prematurity (43%). Specific causes (22%) of perinatal deaths were predominantly infections, including one case of congenital syphilis. Perinatal asphyxia was diagnosed in 14%, and there was one case (7%) of a chromosome abnormality. Infant deaths were predominantly due to respiratory (45%) and gastrointestinal infections (28%), with chronic malnutrition as an underlying cause in 80% of cases. Prenatal care could theoretically have prevented three of the perinatal deaths, and a further six deaths could have been avoided by improved management of labor and the immediate neonatal period. Prevention of malnutrition and improved treatment of acute infections would contribute to a reduction in infant mortality in this population. The Pró-Natal project will use these data to design preventative interventions to reduce perinatal and infant mortality in this communityArticle The effectiveness of community-based interventions to improve maternal and infant health in the Northeast of Brazil(2002) Emond, Alan; Pollock, Jon; Costa, Nilma da; Maranhão, Técia Maria de Oliveira; Macedo, Albanita Leite Soares deObjective. To evaluate the effectiveness of a community-based intervention project aimed at reducing maternal and infant mortality in a poor urban district in the city of Natal, in the Northeast of Brazil. Methods. The intervention, called the ProNatal project, introduced a program of integrated community health care to a geographically defined population. The interventions included the establishment of antenatal clinics at the district’s health centers, the opening of the maternity facilities at the polyclinic for low-risk deliveries, the introduction of a family planning clinic and a breast-feeding clinic, support from pediatricians for under-5 (well-baby) clinics, children’s outpatient services and children’s emergency care, and the introduction of health agents recruited from the local community. Representative surveys of the population were taken at the project’s inception (July 1995) and then 30 months later (December 1997), using a general health questionnaire adapted to the local conditions. Mortality data were collected from local registration systems as well as from an autopsy survey of perinatal and infant deaths. Results. During 1995 there were 4 maternal deaths from 1 195 pregnancies (maternal mortality of 335/100 000); three of the deaths were related to hypertension and one to uterine perforation after an illegal abortion. During 1998 (post-intervention), there were no maternal deaths in pregnancy or childbirth. In 1993 no deliveries took place at the polyclinic, but in 1998 there were 946 deliveries at the clinic without any serious complications. The method of delivery, the incidence of prematurity, and the incidence of low birthweight did not change significantly over the study period. In the post-intervention survey, 75% of women reported receiving contraceptive advice from a doctor in the preceding year, compared to 50% in the first sample. A mortality survey carried out in 1993–1995 estimated the infant mortality rate to be 60/1 000 live births. By 1998, using data collected locally by active surveillance, the infant mortality rate was 37/1 000 live births. The causes of infant death in both those periods were dominated by respiratory infections and diarrheal disease. Over 95% of both samples initiated breast-feeding, but a higher proportion of the post-intervention sample reported breast-feeding for longer than 6 months (41% vs. 32%, P = 0.0005). No differences were apparent in the use of under-5 clinics, but immunization rates improved. Post-intervention, significant improvements were documented in the mothers’ understanding of basic hygiene, their knowledge of causes of common diseases, and their management of acute respiratory infections and diarrhea in children. This was particularly true for the households visited by a community health agent. Conclusions. Inequalities in health care in poor urban populations can be reduced by integrated community-based interventions, including the use of health agents recruited from the local communityArticle Procoagulant state after raloxifene therapy in postmenopausal women(2005) Azevedo, George Dantas de; Franco, Rendrik França; Baggio, Márcia Sueli; Maranhão, Técia Maria de Oliveira; Sá, Marcos Felipe Silva deObjective: To investigate the effects of raloxifene on the hemostatic system in postmenopausal women. Design: A prospective longitudinal study. Setting: Outpatient clinic of the Faculty of Medicine of Ribeirão Preto, Brazil. Patient(s): Sixteen postmenopausal women aged 56.8 5.9 years (mean SD). Intervention(s): Raloxifene hydrochloride (60 mg once daily) was administered orally for a period of 6 months. Main Outcome Measure(s): Plasma activities of coagulation factors (II, V, VII, VIII, IX, X, XI, XII, and fibrinogen), prothrombin-derived fragment 1 2, and activated protein C (APC) sensitivity ratio were measured at baseline and after 1, 3, and 6 months of treatment. Result(s): Factor VIII activity increased by 17.1% and 26.9% at 3 and 6 months of treatment, respectively, compared with baseline. Factor XI and FXII activities significantly increased by 10.9% and 43.1%, respectively, after 6 months compared with baseline. A significant reduction of APC sensitivity ratio also was observed after 6 months of treatment. Conclusion(s): A procoagulant state characterized by increased factor VIII, XI, and XII plasma levels and by reduced APC sensitivity was observed after raloxifene therapy in post-menopausal womenArticle Raloxifene therapy does not affect uterine blood flow in postmenopausal women: a transvaginal Doppler study(2004) Azevedo, George Dantas de; Prado, Maria Fernanda Massoni do; Ferriani, Rui Alberto; Reis, Rosana Maria dos; Berezowski, Aderson Tadeu; Ribeiro, Tatiane Flores; Silva, Ester; Maranhão, Técia Maria de Oliveira; Sá, Marcos Felipe Silva deObjective:To monitor the effects of raloxifene therapy on the uterus of postmenopausalwomen by transvaginal ultrasonography and color flow Doppler. Methods: Twenty-five healthy postmenopausal women were enrolled in this prospective longitudinal study performed at Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirão Preto. The patients were treated with raloxifene hydrochloride (60 mg per day) for 6 months. All were submitted to transvaginal ultrasound examination with color flow Doppler (ATL-HDI 3000 equipment) before the beginning and after 1, 3 and 6 months of treatment. Resistance index (RI) and pulsatility index (PI) of the uterine arteries were determined by the Doppler method, being considered as indicators of uterine perfusion. The following variables were analyzed: endometrial thickness, uterine volume, RI, and PI. Data were analyzed statistically by repeated-measures analysis of variance. Results: Before treatment, endometrial thickness was 3.38 ± 0.73 mm, and similar values were observed after 1, 3 and 6 months of treatment (3.04 ± 0.82; 3.3 ± 0.83; and 3.37 ± 0.79, respectively) (P > 0.05). No significant differences in uterine volume were observed between the pre- and post-treatment periods. Uterine artery perfusion as indicated by RI and PI measured by Doppler also showed no significant variation, with a high impedance flow being maintained throughout treatment. Conclusions: In the group studied here, raloxifene treatment at the dose of 60 mg per day for 6 months did not induce significant changes in endometrial thickness, uterine volume or uterine artery perfusion, confirming that short-term raloxifene treatment does not affect the uterus of postmenopausal women