Programa de pós-graduação em Ciências da Reabilitação
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Master Thesis Estimulação transcraniana por corrente contínua melhora dor e qualidade de vida em pacientes com Polineuropatia diabética: ensaio clínico randomizado(2018-07-31) Ferreira, Galeno Jahnssen Bezerra de Menezes; Freitas, Rodrigo Pegado de Abreu; ; ; Gualdi, Lucien Peroni; ; Lixandrão, Maíra Carolina;Introduction: Diabetes Mellitus is Classified as a chronic disease that as a characteristics peripheral nerve injury and neuropathic pain. It is a disease that effects several organs and systems and can generate serious vascular complication, being the main cause of painful diabetic neuropathic (PDN). In the long run for patients with diabetes, PDN is considered one of the major complications. It is characterized by constants pain that greatly affects the quality of life (QoL) of diabetic patients. The treatment is a challenge for the multiprofessional team, since in some cases the pain presents no significant pattern of improvement or is partially resolved with the use of medication. Objective: This study aimed to evaluate the effects of anodal tDCS of the M1 on QoL, physical fitness and pain in patients with diabetic polyneuropathy. Subjects and methods: It was conducted a two arms, parallel, sham, randomized, double-blind trial with twenty patients with diabetic polyneuropathy. Five consecutive sessions of C3/Fp2 tDCS montage were done. Quality of life according to SF-36 and pain were used to assess the primary outcome. Secondary outcomes measures was physical fitness level according to lower and upper body strength, flexibility and submaximal level of functional capacity. All outcomes were measured in 3 different times (baseline, 1 week and 2 week). Results: Generalized estimating equations (GEE) showed significant main effects of time x group on SF-36 score (x2 = 48.79; p < 0.001) with significant difference between baseline to 1 week (p = 0.001) and 2 week (p = 0.001). SF-36 score showed significant difference between group only on 2 week (p = 0.05). Mental health, physical health, emotional, general health, physical function and functional capacity showed significant interaction time x group with increase in Active-tDCS group. Bodily pain differ between groups in 2 week (p = 0.001). TUG and 6MWT have shown significant improvement only in Active-tDCS group (p = 0.0075; p = 0.0001 respectively, according to ANOVA). Conclusions: Five sessions of anodal M1 tDCS improve QoL, pain and functionality in patients with diabetic polyneuropathy.