Instituto do Cérebro
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Article Similarities and differences between natural sleep and urethane anesthesia(Springer Science and Business Media LLC, 2025) Brankačk, Jurij; Yanovsky, Yevgenij; Tort, Adriano Bretanha Lopes; Draguhn, Andreas; https://orcid.org/0000-0002-9877-7816Article Respiration and rapid eye movement (REM) sleep substructure: short versus long episodes(Wiley, 2022-11) Hammer, Maximilian; Jung, Felix; Brankačk, Jurij; Yanovsky, Yevgenij; Tort, Adriano Bretanha Lopes; Draguhn, AndreasArticle Theta-gamma coupling during REM sleep depends on breathing rate(Oxford University Press, 2021-07-23) Hammer, Maximilian; Schwale, Chrysovalandis; Brankačk, Jurij; Draguhn, Andreas; Tort, Adriano Bretanha LopesArticle Respiration-entrained brain rhythms are global but often overlooked(2018-04) Tort, Adriano Bretanha Lopes; Brankack, Jurij; Draguhn, AndreasArticle Parallel detection of theta and respiration-coupled oscillations throughout the mouse brain(2018-04-24) Tort, Adriano Bretanha Lopes; Ponsel, Simon; Jessberger, Jakob; Yanovsky, Yevgenij; Brankačk, Jurij; Draguhn, AndreasArticle Impaired theta-gamma coupling in APP-defcient mice(2016-02-24) Zhang, Xiaomin; Zhong, Wewei; Brankačk, Jurij; Weyer, Sascha W.; Müller, Ulrike C.; Tort, Adriano Bretanha Lopes; Draguhn, AndreasArticle Hippocampal Respiration-Driven Rhythm Distinct from Theta Oscillations in Awake Mice(2016) Chi, Vivan Nguyen; Muller, Carola; Wolfenstetter, Thérèse; Yanovsky, Yevgenij; Draguhn, Andreas; Tort, Adriano Bretanha Lopes; Brankack, JurijArticle Selective entrainment of gamma subbands by different slow network oscillations(2017-03-16) Zhong, Weiwei; Ciatipis, Mareva; Wolfenstetter, Thérèse; Jessberger, Jakob; Müller, Carola; Ponsel, Simon; Yanovsky, Yevgenij; Brankack, Jurij; Tort, Adriano Bretanha Lopes; Draguhn, AndreasArticle Slow Oscillations in the Mouse Hippocampus Entrained by Nasal Respiration(2014-04-23) Yanovsky, Yevgenij; Ciatipis, Mareva; Draguhn, Andreas; Tort, Adriano Bretanha Lopes; Brankacˇk, JurijDifferent types of network oscillations occur in different behavioral, cognitive, or vigilance states. The rodent hippocampus expresses prominentoscillations atfrequencies between 4 and 12Hz,which are superimposed by phase-coupledoscillations (30 –100Hz).These patterns entrain multineuronal activity over large distances and have been implicated in sensory information processing and memory formation. Here we report a new type of oscillation at near- frequencies (2– 4 Hz) in the hippocampus of urethane-anesthetized mice. The rhythm is highly coherent with nasal respiration and with rhythmic field potentials in the olfactory bulb: hence, we called it hippocampal respiration-induced oscillations. Despite the similarity in frequency range, several features distinguish this pattern from locally generatedoscillations: hippocampal respiration-induced oscillations have a unique laminar amplitude profile, are resistant to atropine, couple differentlytooscillations, and are abolished when nasal airflow is bypassed bytracheotomy. Hippocampal neurons are entrained by both the respiration-induced rhythm and concurrent oscillations, suggesting a direct interaction between endogenous activity in the hippocampus and nasal respiratory inputs. Our results demonstrate that nasal respiration strongly modulates hippocampal network activity in mice, providing a long-range synchronizing signal between olfactory and hippocampal networks.Article Global slowing of network oscillations in mouse neocortex by diazepam(2013) Scheffzük, Claudia; Kukushka, Valeriy I.; Vyssotski, Alexei L.; Draguhn, Andreas; Tort, Adriano Bretanha Lopes; Branka, JurijBenzodiazepines have a broad spectrum of clinical applications including sedation, anti-anxiety, and anticonvulsive therapy. At the cellular level, benzodiazepines are allosteric modulators of GABAA receptors; they increase the efficacy of inhibition in neuronal networks by prolonging the duration of inhibitory postsynaptic potentials. This mechanism of action predicts that benzodiazepines reduce the frequency of inhibition-driven network oscillations, consistent with observations from human and animal EEG. However, most of existing data are restricted to frequency bands beloww30 Hz. Recent data suggest that faster cortical network rhythms are critically involved in several behavioral and cognitive tasks. We therefore analyzed diazepam effects on a large range of cortical network oscillations in freely moving mice, including theta (4e12 Hz), gamma (40e100 Hz) and fast gamma (120e160 Hz) oscillations. We also investigated diazepam effects over the coupling between theta phase and the amplitude fast oscillations. We report that diazepam causes a global slowing of oscillatory activity in all frequency domains. Oscillation power was changed differently for each frequency domain, with characteristic differences between active wakefulness, slow-wave sleep and REM sleep. Cross-frequency coupling strength, in contrast, was mostly unaffected by diazepam. Such state- and frequency-dependent actions of benzodiazepines on cortical network oscillations may be relevant for their specific cognitive effects. They also underline the strong interaction between local network oscillations and global brain states