Instituto do Cérebro
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Article CaMKII modulates memory destabilization by regulating the interaction of theta and gamma oscillations(Frontiers Media SA, 2025) Rossato, Janine Inez; Gonzalez, Maria Carolina; Souza, Johseph Paballo Gomes de; Radiske, Andressa; Apolinário, Gênedy Karielly da Silva; Baracho, Ana Luizi; Cammarota, Martín PabloArticle NMDARs control object recognition memory destabilization and reconsolidation(Elsevier BV, 2023-04) Rossato, Janine Inez; Radiske, Andressa; Gonzalez, Maria Carolina; Apolinário, Gênedy Karielly da Silva; Araújo, Raquel Lúcia Souto de; Bevilaqua, Lia Rejane Muller; Cammarota, Martín PabloArticle On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory(Frontiers Media SA, 2022-12) Rossato, Janine Inez; Radiske, Andressa; Gonzalez, Maria Carolina; Bevilaqua, Lia Rejane Muller; Cammarota, Martín PabloArticle Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation(Springer Science and Business Media LLC, 2022-06-07) Gonzalez, Maria Carolina; Radiske, Andressa; Rossato, Janine; Conde-Ocazionez, Sergio; Bevilaqua, Lia Rejane Muller; Cammarota, Martin PabloArticle Avoidance memory requires CaMKII activity to persist after recall(2021-11-14) Radiske, Andressa; Gonzalez, Maria Carolina; Rossato, Janine Inez; Apolinário, Gênedy Karielly da Silva; Oliveira, João R. de; Bevilaqua, Lia Rejane Müller; Cammarota, Martín PabloArticle Requirement for BDNF in the Reconsolidation of Fear Extinction(2015-04-22) Radiske, Andressa; Rossato, Janine I.; Köhler, Cristiano A.; Gonzalez, Maria Carolina; Medina, Jorge H.Therapies based on the impairment of reconsolidation or the enhancement of extinction offer the possibility of decreasing the persistent recollection of distressing memories. However, the direct interplay between reconsolidation and extinction has rarely been considered. Previously, we reported that reactivation induces reconsolidation of fear extinction memory. Here, using a step-down inhibitory avoidance learning paradigm in rats, we show that intrahippocampus infusion of function-blocking anti-BDNF antibody immediately or 6 h after extinction memory reactivation impairs the reconsolidation of extinction. Extinction memory reactivation increases proBDNF, BDNF, and tropomyosin receptor kinase B (TrkB) phosphorylation levels in dorsal CA1, while blocking BDNF maturation in the hippocampus with plasminogen activator inhibitor 1 hinders the persistence of extinction and induces the recurrence of fear. Moreover, coinfusion of recombinant BDNF (0.25 g/side) after extinction memory reactivation impedes the recovery of the avoidance response induced by inhibiting gene expression and protein synthesis in the dorsal hippocampus. Our findings unravel a new role for BDNF, suggesting that this neurotrophin is necessary and sufficient to maintain the reactivated fear extinction engram.