Instituto do Cérebro
Permanent URI for this communityhttps://repositorio.ufrn.br/handle/1/6191
Browse
8 results
Search Results
Article Subacute effects of the psychedelic ayahuasca on the salience and default mode networks(2020-04-07) Pasquini, Lorenzo; Palhano-Fontes, Fernanda; Araújo, Dráulio Barros deArticle Modulation of serum brain-derived neurotrophic factor by a single dose of Ayahuasca: observation from a randomized controlled trial(2019-06-04) Almeida, Raíssa Nóbrega de; Galvão, Ana Cecília de Menezes; Silva, Flávia Santos da; Silva, Erick Allan dos Santos; Palhano-Fontes, Fernanda; Maia-de-Oliveira, João Paulo; Araújo, Dráulio Barros de; Lobão-Soares, Bruno; Galvão-Coelho, Nicole LeiteArticle Characterizing complex networks using entropy-degree diagrams: unveiling changes in functional brain connectivity induced by ayahuasca(2019-01-30) Viol, Aline; Palhano-Fontes, Fernanda; Onias, Heloisa; Araújo, Dráulio Barros de; Hövel, Philipp; Viswanathan, Gandhi M.Article Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial(2018-06-15) Palhano-Fontes, Fernanda; Barreto, Dayanna; Onias, Heloisa; Andrade, Katia C.; Novaes, Morgana M.; Pessoa, Jessica A.; Mota-Rolim, Sergio A.; Osório, Flávia L.; Sanches, Rafael; Santos, Rafael G. dos; Tófoli, Luís Fernando; Silveira, Gabriela de Oliveira; Yonamine, Mauricio; Riba, Jordi; Santos, Francisco R.; Silva-Junior, Antonio A.; Alchieri, João C.; Galvão-Coelho, Nicole L.; Lobão-Soares, Bruno; Hallak, Jaime E. C.; Arcoverde, Emerson; Maia-de-Oliveira, João P.; Araújo, Dráulio Barros deArticle Shannon entropy of brain functional complex networks under the infuence of the psychedelic Ayahuasca(2017-08-07) Viol, A.; Palhano-Fontes, Fernanda; Onias, Heloisa; Araújo, Dráulio Barros de; Viswanathan, G. M.Article Long-term use of psychedelic drugs is associated with differences in brain structure and personality in humans(2015) Bouso, José Carlos; Palhano-Fontes, Fernanda; Rodríguez-Fornells, Antoni; Ribeiro, Sidarta Tollendal Gomes; Sanches, Rafael; Crippa, José Alexandre S.; Hallak, Jaime E.C.; Araújo, Dráulio Barros de; Riba, JordiArticle Shannon entropy of brain functional complex networks under the influence of the psychedelic Ayahuasca(2016) Viol, A.; Palhano-Fontes, Fernanda; Onias, Heloisa; Araújo, Dráulio Barros de; Viswanathan, G. M.Article The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network(Plos One, 2015-02-18) Palhano-Fontes, Fernanda; Andrade, Katia C.; Tofoli, Luis F.; Santos, Antonio C.; Crippa, Jose Alexandre S.; Hallak, Jaime E. C.; Ribeiro, Sidarta Tollendal Gomes; Araújo, Dráulio Barros deThe experiences induced by psychedelics share a wide variety of subjective features, related to the complex changes in perception and cognition induced by this class of drugs. A remarkable increase in introspection is at the core of these altered states of consciousness. Self-oriented mental activity has been consistently linked to the Default Mode Network (DMN), a set of brain regions more active during rest than during the execution of a goal-directed task. Here we used fMRI technique to inspect the DMN during the psychedelic state induced by Ayahuasca in ten experienced subjects. Ayahuasca is a potion traditionally used by Amazonian Amerindians composed by a mixture of compounds that increase monoaminergic transmission. In particular, we examined whether Ayahuasca changes the activity and connectivity of the DMN and the connection between the DMN and the task-positive network (TPN). Ayahuasca caused a significant decrease in activity through most parts of the DMN, including its most consistent hubs: the Posterior Cingulate Cortex (PCC)/Precuneus and the medial Prefrontal Cortex (mPFC). Functional connectivity within the PCC/Precuneus decreased after Ayahuasca intake. No significant change was observed in the DMN-TPN orthogonality. Altogether, our results support the notion that the altered state of consciousness induced by Ayahuasca, like those induced by psilocybin (another serotonergic psychedelic), meditation and sleep, is linked to the modulation of the activity and the connectivity of the DMN.