Programa de Pós-Graduação em Ciências Farmacêuticas
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Master Thesis Planejamento, síntese e avaliação biológica de hidrazonas e 1,2,3-triazóis(Universidade Federal do Rio Grande do Norte, 2024-02-29) Ferreira, Housemberg Donanvam da Silva; Jordão, Alessandro Kappel; Barbosa, Euzébio Guimarães; http://lattes.cnpq.br/3197108792266393; https://orcid.org/0000-0002-2920-3966; http://lattes.cnpq.br/2003461080025290; http://lattes.cnpq.br/1948445205661935; Gomes, Ana Paula Barreto; Gonzaga, Daniel Tadeu GomesHydrazones and triazoles comprise biologically active and synthetically viable chemical groups that are widely studied largely due to their extensive biological potential. Chapter one covers the entire synthesis process of 1,2,3-triazole compounds derived from amino acids, which, through four reaction steps starting from phenylalanine, resulted in the formation of five new compounds with yields between 22% and 55%. . From virtual screening studies, the possible biological activity of these compounds against the HCV virus, which causes hepatitis C, was verified. However, concrete experimental research data is still needed to prove this hypothesis. In the second chapter, the syntheses of hydrazonic compounds will be discussed starting from the drug isoniazid, where nine hydrazonic compounds were formed from reactions with different aromatic aldehydes with yields ranging from 25% to 92%. Based on virtual screening studies involving the hydrazones produced in this work, the hypothesis was formulated that these molecules have potential antineoplastic activity. Furthermore, due to the vast biological potential that these molecules present, the modulatory activity of antimicrobial resistance was evaluated based on evaluation of strains resistant to commercialized antimicrobials, and it was noted that the molecules produced in this work had a synergistic effect with the drugs studied in the tests, modulating the resistance of bacterial strains. However, additional tests will still be carried out to complete this study. In this work, a new synthetic step involving hydrazonic compounds was also investigated for the formation of their 4,5- dihydro-oxadiazole derivatives, obtaining a compound with a yield of 93%.Master Thesis Microemulsão tópica contendo Anfotericina B visando o tratamento de onicomicoses(Universidade Federal do Rio Grande do Norte, 2022-07-07) Souza, Aleph Matthews da Silva; Egito, Eryvaldo Socrates Tabosa do; Alencar, Éverton do Nascimento; http://lattes.cnpq.br/6907806915889763; http://lattes.cnpq.br/9571864533462140; Oliveira, Anselmo Gomes de; Chaves, Guilherme Maranhão; https://orcid.org/0000-0002-0170-9383; http://lattes.cnpq.br/1463249528959656