Programa de Pós-Graduação em Ciências Farmacêuticas
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Master Thesis Estabilidade da Anfotericina B em um carreador nanotecnológico(Universidade Federal do Rio Grande do Norte, 2016-04-29) Santos, Sarah Rafaelly Araújo; Egito, Eryvaldo Sócrates Tabosa do; Azeredo, Francine Johansson; http://lattes.cnpq.br/6907806915889763; http://lattes.cnpq.br/1287626190706313; Lima, Adley Antonini Neves de; https://orcid.org/0000-0002-3798-3915; http://lattes.cnpq.br/4061809277935577; Ramaldes, Gilson AndradeAmphotericin B is a water-insoluble compound widely used to effectively treat systemic fungal infections. The use of more effective therapies with higher doses of AmB directed to invasive systemic mycoses, together with a real need to reduce AmB intrinsic toxicity, has trigged the development of alternative carriers for AmB administration. Lipid microemulsions have been very important in the pharmaceutical field, once they are pharmacologically more efficient and present reduced side effects. Thus, this work aimed to evaluate the stability and the pharmacological and the toxic profile of AmB incorporated in a microemulsion system (AmB-ME), and to compare its performance with free and conventional AmB. To assess AmB stability, the formulations were subjected to a stress study (thermal stress and UV luminous radiation) and accelerated stability studies for 90 days, in which the formulations were stored at 25ºC and 45ºC. Then, at pre-determined times, the AmB content, followed by activity and toxicity assays, was evaluated. The results showed that AmB has higher susceptibility to UV luminous radiation rather than high temperatures. For all formulations, AmB presented a first order kinetic degradation profile. However, AmB-ME revealed the shortest degradation profile for a shelf-life of almost 30 days. Regarding the antifungal activity, the AmB-ME formulation was able to inhibit C.parapsilosis growth during 90 days of the experiment. Nevertheless, AmB-ME showed higher toxicity levels, as revealed by potassium and hemoglobin release assays. Thus, the microemulsion can be considered a very interesting strategy to stabilize AmB under the stress conditions, but it is necessary to optimize the product formulation to minimize possible cellular damage.Master Thesis Microemulsão tópica contendo Anfotericina B visando o tratamento de onicomicoses(Universidade Federal do Rio Grande do Norte, 2022-07-07) Souza, Aleph Matthews da Silva; Egito, Eryvaldo Socrates Tabosa do; Alencar, Éverton do Nascimento; http://lattes.cnpq.br/6907806915889763; http://lattes.cnpq.br/9571864533462140; Oliveira, Anselmo Gomes de; Chaves, Guilherme Maranhão; https://orcid.org/0000-0002-0170-9383; http://lattes.cnpq.br/1463249528959656Master Thesis Desenvolvimento de hidrogéis de poli (álcool vinílico) contendo anfotericina B para o tratamento de leishmaniose tegumentar americana(2015-03-31) Alexandrino Júnior, Francisco; Egito, Eryvaldo Sócrates Tabosa do; ; http://lattes.cnpq.br/6907806915889763; ; http://lattes.cnpq.br/7620675279773626; Balaban, Rosângela de Carvalho; ; http://lattes.cnpq.br/7711521318854102; Lione, Viviane de Oliveira Freitas; ; http://lattes.cnpq.br/7700565158061560