Programa de Pós-Graduação em Ciências Farmacêuticas
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Master Thesis Avaliação dos parâmetros de estresse oxidativo no lúpus eritematoso(Universidade Federal do Rio Grande do Norte, 2009-03-27) Costa, Tatiana Xavier da; Lemos, Telma Maria Araujo Moura; ; http://lattes.cnpq.br/4311626091295357; ; http://lattes.cnpq.br/1775286763156268; Vilar, Maria José Pereira; ; http://lattes.cnpq.br/4265369922470937; Cavagis, Alexandre Donizeti Martins; ; http://lattes.cnpq.br/0907530041669620OBJECTIVE: The aim of this work was to analyse some oxidative stress parameters in patients of Systemic Lúpus Erythematosus. PATIENTS AND METHODS: Determinations of reduced glutathione content in whole blood were carried out. The activity of superoxide dismutase, gluthatione peroxidase and catalase in erythrocytes and the concentration of reactive substances of acid thiobarbituric in plasma of patients female (n =19) with SLE no activity of disease (Mex-SLEDAI < 2), with average ages of 32 ± 11 years, through the spectrophotometrical methods and from healthy individuals (n =30). Statistical data were analyzed by student t-test, p<0,05. RESULTS: Our data indicated a significant decrease on the activity of catalase and significant increase on the concentration of reactive substances of acid thiobarbituric in patients with SLE comparing with healthy individuals. There was no significant difference in other parameters. CONCLUSION: The results showed that oxidative stress has a role in the pathogenesis of the disease in SLE, even in patients without active disease.