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dc.contributor.authorMedeiros, Paulo José de-
dc.contributor.authorNeto, Arthur Villarim-
dc.contributor.authorLima, Francisco Pignataro-
dc.contributor.authorAzevedo, Ítalo Medeiros-
dc.contributor.authorLeão, Layra Ribeiro de Sousa-
dc.contributor.authorMedeiros, Aldo Cunha-
dc.identifier.citationMEDEIROS, P. J. ; Villarim Neto, Arthur ; LIMA, Francisco Pignataro ; AZEVEDO, Ítalo Medeiros ; LEAO, L. R. S. ; MEDEIROS, A. C. . Effect of sildenafil in renal ischemia/reperfusion injury in rats. Acta Cirurgica Brasileira (Impresso) , v. 25, p. 490-495, 2010. Disponível em: <>. Acesso em:19 set.2013.pt_BR
dc.description.abstractTo evaluate the effect of sildenafil, administered prior to renal ischemia/reperfusion (I/R), by scintigraphy and histopathological evaluation in rats. Methods: Twenty-four rats were divided randomly into two groups. They received 0.1 ml of 99mTechnetium-etilenodicisteine intravenous, and a baseline (initial) renal scintigraphy was performed. The rats underwent 60 minutes of ischemia by left renal artery clamping. The right kidney was not manipulated. The sildenafil group (n=12) received orally 1 mg/kg of sildenafil suspension 60 minutes before ischemia. Treatment with saline 0.9% in the control group (n=12). Half of the rats was assessed after 24 hours and half after seven days I/R, with new renal scintigraphy to study differential function. After euthanasia, kidneys were removed and subjected to histopathological examination. For statistical evaluation, Student t and Mann-Whitney tests were used. Results: In the control group rats, the left kidneys had significant functional deficit, seven days after I/R, whose scintigraphic pattern was consistent with acute tubular necrosis, compared with the initial scintigraphy (p<0.05). Sildenafil treatment resulted in better differential function of the left kidneys 24h after reperfusion, compared with controls. Histopathologically, the left kidney of control rats (24 hours after I/R) showed a higher degree of cellular necrosis when compared with the sildenafil treated rats (p<0.05). Conclusion: Sildenafil had a protective effect in rat kidneys subjected to normothermic I/R, demonstrated by scintigraphy and histomorphometrypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectRadionuclide Imagingpt_BR
dc.subjectTechnetium Tc 99m Mertiatidept_BR
dc.titleEffect of sildenafil in renal ischemia/reperfusion injury in ratspt_BR
dc.title.alternativeEfeito do sildenafil na lesão renal por isquemia-reperfusão em ratospt_BR
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