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Title: Translocation of 99mTc labelled bacteria after intestinal ischemia and reperfusion
Other Titles: Translocação de bactérias marcadas com 99mTc após isquemia e reperfusão intestinal
Authors: João, Samir Assi
Alencar, Suelene Suassuna Silvestre de
Medeiros, Aldo da Cunha
Diniz, Simone Otília Fernandes
Cardoso, Valbert Nascimento
Brandt, Carlos Teixeira
Keywords: Bacterial translocation;Ischemia;Reperfusion;Intestine;99mTechnecium labelled bacteria
Issue Date: 2004
Citation: JOÃO, Samir Assi ; ALENCAR ,Suelene Suassuna Silvestre de ; MEDEIROS, Aldo da Cunha ; DINIZ, Simone Otília Fernandes ; CARDOSO, Valbert Nascimento ; BRANDT, Carlos Teixeira. Translocation of 99mTc labelled bacteria after intestinal ischemia and reperfusion. Acta Cirúrgica Brasileira, São Paulo, v. 19, n.4, p. 328-333, 2004. Disponível em:<> Acesso em: 30 set. 2013
Abstract: Ischemia and reperfusion of the small intestine disrupts gut barrier, causes bacterial translocation and activates inflammatory responses. An experimental study was planned to evaluate if 99mTc labelled Escherichia coli translocates to mesenteric lymph nodes, liver, spleen, lung and serum of rats submitted to mesenteric ischemia/reperfusion. Additionally, it was observed if the time of reperfusion influences the level of translocation. METHODS: Forty male Wistar rats underwent 45 minutes of gut ischemia by occlusion of the superior mesenteric artery. The translocation of labelled bacteria to different organs and portal serum was determined in rats reperfused for 30 minutes, 24 hours, sham(S) and controls(C), using radioactivity count and colony forming units/g (CFU). RESULTS: All the organs from rats observed for 24 hours after reperfusion had higher levels of radioactivity and positive cultures (CFU) than did the organs of rats reperfused for 30 minutes, C and S, except in the spleen (p<0,01). CONCLUSION: The results of this study indicated that intestinal ischemia/reperfusion led to bacterial translocation, mostly after 24 hours of reperfusion
ISSN: 1678-2674
Appears in Collections:CCS - DCIRUR - Artigos publicados em periódicos

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