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https://repositorio.ufrn.br/handle/123456789/21208| Title: | Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs |
| Authors: | Pereira, Karuza Maria Alves Amaral, Bruna Aguiar do Santos, Bruna Rafaela Martins dos Galvão, Hebel Cavalcanti Freitas, Roseana de Almeida Souza, Lelia Batista de |
| Keywords: | Immunohistochemical;E-cadherin;beta-catenin;ameloblastoma |
| Issue Date: | 2010 |
| Citation: | PEREIRA, Karuza Maria Alves et al. Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, v. 109, n. 3, p. 425-431, 2010. |
| Portuguese Abstract: | OBJECTIVE: The aim was to analyze the expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs to determine their roles in cell differentiation processes and invasiveness compared with odontogenesis. STUDY DESIGN: Twenty-one ameloblastoma cases (16 solid and 5 unicystic tumors) and 5 tooth germs were submitted to the immunohistochemical detection of E-cadherin and beta-catenin. Immunoreactivity was evaluated using descriptive and semiquantitative analysis, investigating the location and intensity of staining. The Fisher exact test was performed, and P values of <.05 were considered to indicate statistical significance. RESULTS: There was no statistically significant difference in the expression of E-cadherin and beta-catenin between solid and unicystic ameloblastomas (P = .59; P = .63; respectively). The same was found when comparing solid and unicystic ameloblastomas with the tooth germs for both E-cadherin (P = .53; P = .44; respectively) and beta-catenin (P = .12; P = .16; respectively). Nuclear staining of beta-catenin was observed in only 4 cases (3 solid and 1 unicystic tumor). CONCLUSION: The results showed no differences in the expression of E-cadherin or beta-catenin between tooth germs and solid and unicystic ameloblastomas. The expression of these molecules seems mainly to be related to the process of cell differentiation. |
| URI: | https://repositorio.ufrn.br/jspui/handle/123456789/21208 |
| Appears in Collections: | CCS - DOD - Artigos publicados em periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Immunohistochemical expression of E-cadherin and_2010.pdf | 2,05 MB | Adobe PDF |  View/Open |
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