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Title: Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs
Authors: Pereira, Karuza Maria Alves
Amaral, Bruna Aguiar do
Santos, Bruna Rafaela Martins dos
Galvão, Hebel Cavalcanti
Freitas, Roseana de Almeida
Souza, Lelia Batista de
Keywords: Immunohistochemical;E-cadherin;beta-catenin;ameloblastoma
Issue Date: 2010
Citation: PEREIRA, Karuza Maria Alves et al. Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, v. 109, n. 3, p. 425-431, 2010.
Portuguese Abstract: OBJECTIVE: The aim was to analyze the expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs to determine their roles in cell differentiation processes and invasiveness compared with odontogenesis. STUDY DESIGN: Twenty-one ameloblastoma cases (16 solid and 5 unicystic tumors) and 5 tooth germs were submitted to the immunohistochemical detection of E-cadherin and beta-catenin. Immunoreactivity was evaluated using descriptive and semiquantitative analysis, investigating the location and intensity of staining. The Fisher exact test was performed, and P values of <.05 were considered to indicate statistical significance. RESULTS: There was no statistically significant difference in the expression of E-cadherin and beta-catenin between solid and unicystic ameloblastomas (P = .59; P = .63; respectively). The same was found when comparing solid and unicystic ameloblastomas with the tooth germs for both E-cadherin (P = .53; P = .44; respectively) and beta-catenin (P = .12; P = .16; respectively). Nuclear staining of beta-catenin was observed in only 4 cases (3 solid and 1 unicystic tumor). CONCLUSION: The results showed no differences in the expression of E-cadherin or beta-catenin between tooth germs and solid and unicystic ameloblastomas. The expression of these molecules seems mainly to be related to the process of cell differentiation.
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