Please use this identifier to cite or link to this item: https://repositorio.ufrn.br/handle/123456789/21808
Title: Immunoexpression of vascular endothelial growth factor in periapical granulomas, radicular cysts, and residual radicular cysts
Authors: Nonaka, Cassiano Francisco Weege
Maia, Alexandre Pinto
Nascimento, George João Ferreira do
Freitas, Roseana de Almeida
Souza, Lelia Batista de
Galvão, Hebel Cavalcanti
Keywords: Immunohistochemistry;Endothelial Growth Factors;Odontogenic Cysts
Issue Date: 2008
Citation: NONAKA, Cassiano Francisco Weege et al. Immunoexpression of vascular endothelial growth factor in periapical granulomas, radicular cysts, and residual radicular cysts.. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics , v. 106, n. 6, p. 896-902, 2008.
Portuguese Abstract: OBJECTIVE: Our aim was to assess and compare the immunoexpression of vascular endothelial growth factor (VEGF) in periapical granulomas (PGs), radicular cysts (RCs), and residual radicular cysts (RRCs), relating it to the angiogenic index and the intensity of the inflammatory infiltrate. STUDY DESIGN: Twenty PGs, 20 RCs, and 10 RRCs were evaluated by immunohistochemistry using anti-VEGF antibody. Angiogenic index was determined by microvessel count (MVC) using anti-von Willebrand factor antibody. RESULTS: The PGs and RCs showed higher expression of VEGF than the RRCs. Lesions presenting few inflammatory infiltrate revealed the lowest immunoexpression of VEGF (P < .05). Irrespective of the intensity of the inflammatory infiltrate, most of the RCs and RRCs showed moderate to strong epithelial expression of VEGF. Lesions showing dense inflammatory infiltrate presented higher MVC indices (P < .05). VEGF expression and MVC did not reveal a significant correlation (P > .05). CONCLUSIONS: VEGF is present in periapical inflammatory lesions but at a lower level in RRCs. The expression of this proangiogenic factor is closely related to the intensity of the inflammatory infiltrate in these lesions.
URI: https://repositorio.ufrn.br/jspui/handle/123456789/21808
Appears in Collections:CCS - DOD - Artigos publicados em periódicos

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