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Title: Oral Langerhans cell histiocytosis: case report with follow-up of ten years
Other Titles: Histiocitose de células de Langerhans oral: relato de caso com acompanhamento de dez anos
Authors: Lima, Emeline das Neves de Araújo
Araújo, Eliakim Medeiros Alves de
Oliveira, P. T.
Medeiros, Ana Miryam Costa de
Keywords: Histiocytosis, Langerhans-Cell
Issue Date: 2014
Citation: LIMA, Emeline das Neves de Araújo et al. Oral Langerhans cell histiocytosis: case report with follow-up of ten years. Brazilian Journal of Otorhinolaryngology (Impresso), v. 80, n. 4, p. 366-367, 2014.
Portuguese Abstract: Langerhans cell histiocytosis (LCH) is characterized by clonal proliferation of Langerhans cells exhibiting Birbeck granules and positive immunohistochemistry for S100 and CD1A. A malignant transformation or a functional proliferation of Langerhans cells responding to external stimuli are possible sources. In the oral cavity, they can occasionally present as hyperplasia of the gingiva or ulcers of the cheek, palate, or tongue mucosa. The diagnosis is made after careful examination, and the exclusion of other similar diagnostic possibilities. Several therapeutic modalities have been suggested for LCH, such as intralesional corticosteroid injection, antibiotics, steroids, radiation therapy, and chemotherapy. Surgical options ranging from extensive resections to more conservative approaches are available and, in many cases, healing has resulted from a single biopsy. The present report regards LCH in the oral cavity and emphasizes the rarity of this lesion, as well as the importance of differential diagnosis, treatment, and appropriate follow-up for these patients.
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