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https://repositorio.ufrn.br/handle/123456789/21845| Title: | Immunoexpression of MMPs-1, -2, and -9 in ameloblastoma and odontogenic adenomatoid tumor |
| Authors: | Ribeiro, Betania Fachetti Iglesias, Déborah Pitta Paraíso Nascimento, G. J. F. Galvão, Hebel Cavalcanti Medeiros, Ana Miryam Costa de Freitas, Roseana de Almeida |
| Keywords: | Ameloblastoma;Odontogenic adenomatoid tumor;Matrix metalloproteinases;Extracellular matrix |
| Issue Date: | 2009 |
| Citation: | RIBEIRO, B. F. et al. Immunoexpression of MMPs-1, -2, and -9 in ameloblastoma and odontogenic adenomatoid tumor. Oral Diseases, v. 15, n. 7, p. 472-477, 2009. |
| Portuguese Abstract: | OBJECTIVE: The aim of this study was to evaluate and compare the expression of metalloproteinases-1, -2, and -9 in solid ameloblastoma and adenomatoid odontogenic tumor. METHODS: A total of 20 cases of solid ameloblastoma and 10 cases of adenomatoid odontogenic tumors were selected and immunohistochemically assessed. Metalloproteinases-1, -2, and -9 immunoexpression and their distribution pattern were noted and semiquantitatively scored. The scores obtained were statistically analyzed. RESULTS: Matrix metalloproteinase (MMP)-1 showed a predominant expression in both tumors and was found in stroma and parenchyma. For MMP-2, there was a varied expression, with 80% and 60% of immunoreactive tumor cells in ameloblastoma and adenomatoid odontogenic tumor respectively. Regarding stromal cells, 65% of ameloblastomas and 80% of adenomatoid odontogenic tumors showed positivity. There was immunoexpression of the MMP-9 in parenchymal and stromal cells in all cases of both tumors analyzed. A statistically significant difference in the expression of MMP-1 in relation to the expression of MMP-2 and -9 in ameloblastomas (P < 0.001) was observed. CONCLUSION: The results suggest that these metalloproteinases are related to growth and progression of tumors analyzed, and particularly in ameloblastoma, its highest aggressiveness may be, in part, a result of the active participation of the stromal cells and their products, such as the MMPs studied. |
| URI: | https://repositorio.ufrn.br/jspui/handle/123456789/21845 |
| Appears in Collections: | CCS - DOD - Artigos publicados em periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Immunoexpression of MMPs-1, -2, and -9_2009.pdf | https://www.ncbi.nlm.nih.gov/pubmed/19522745 | 510,06 kB | Adobe PDF |  View/Open |
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