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Title: Multiple Second Primary Oral Squamous Cell Carcinomas in a Nonsmoker and Nondrinker Woman: Case Report and Review of the Literature
Authors: Lopes, Maria Luiza Diniz de Sousa
Aquino, Ana Rafaela Luz de
Morais, Maria de Lourdes Silva de Arruda
Medeiros, Lélia Bristo de
Silveira, Ericka Janine Dantas da
Keywords: Case reports;Oral cancer;Second primary neoplasms;Squamous cell carcinoma;Treatment outcome
Issue Date: 2015
Citation: LOPES, Maria Luiza Diniz de Souza et al. Multiple Second Primary Oral Squamous Cell Carcinomas in a Nonsmoker and Nondrinker Woman: Case Report and Review of the Literature. The Journal of Contemporary Dental Practice, v. 16, n. 4, p. 322-328, 2015.
Portuguese Abstract: AIM: This manuscript aims to describe an unusual case of multiple second primary squamous cell carcinomas (SCCs) in several sites of the oral mucosa in a nonsmoker and nondrinker woman and to discuss the diagnostic criteria, clinicopathological aspects and outcome of second primary tumor (SPT). BACKGROUND: Patients treated for SCC of the head and neck are at high risk for developing SPT arising from the same dysplastic mucosal feld. Currently, there is no reliable method to predict which of the patients will develop SPT. CASE DESCRIPTION: A 64-year-old nonsmoker and nondrinker woman developed several second primary oral SCCs in 7 years of follow-up, most of them being synchronic, treated by surgery without and with chemotherapy and radiotherapy. CONCLUSION: Patients treated for SCC require a long-term and careful follow-up as the development of SPT contributes with significantly negative impact on the prognosis. CLINICAL SIGNIFICANCE: This report describes the diagnosis and management of a very unusual case of several SPTs affecting different sites of the oral mucosa in the same patient. Moreover, the patient had no apparent risk factors associated with the development of the oral cancer. Therefore, a brief update concerning SPT and its diagnosis and management is also provided.
Appears in Collections:CCS - DOD - Artigos publicados em periódicos

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