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|Title:||Sleep and plasticity|
|Keywords:||Adenylyl cyclase;Ca2+ dependence;cAMP;Electrophysiology;Gene expression;Hippocampus;Longterm potentiation;Long-term depression;Memory;Plasticity|
|Portuguese Abstract:||While there is ample agreement that the cognitive role of sleep is explained by sleep-dependent synaptic changes, consensus is yet to be established as to the nature of these changes. Some researchers believe that sleep promotes global synaptic downscaling, leading to a non- Hebbian reset of synaptic weights that is putatively necessary for the acquisition of new memories during ensuing waking. Other investigators propose that sleep also triggers experience-dependent, Hebbian synaptic upscaling able to consolidate recently acquired memories. Here, I review the molecular and physiological evidence supporting these views, with an emphasis on the calcium signaling pathway. I argue that the available data are consistent with sleep promoting experience-dependent synaptic embossing, understood as the simultaneous non-Hebbian downscaling and Hebbian upscaling of separate but complementary sets of synapses, heterogeneously activated at the time of memory encoding and therefore differentially affected by sleep|
|Appears in Collections:||ICe - Artigos publicados em periódicos|
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