Please use this identifier to cite or link to this item: https://repositorio.ufrn.br/handle/123456789/23831
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dc.contributor.authorKroll, José Eduardo-
dc.contributor.authorSilva, Vandeclecio Lira da-
dc.contributor.authorSouza, Sandro José de-
dc.contributor.authorSouza, Gustavo Antonio de-
dc.date.accessioned2017-09-11T17:08:26Z-
dc.date.issued2017-07-
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/23831-
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectalternative splicing eventspt_BR
dc.subjectgenome browserpt_BR
dc.subjectmass spectrometrypt_BR
dc.subjectpeptide identificationpt_BR
dc.subjectproteogenomicspt_BR
dc.titleA tool for integrating genetic and mass spectrometry-based peptide data: proteogenomics viewer: PV: a genome browser-like tool, which includes MS data visualization and peptide identification parameterspt_BR
dc.typearticlept_BR
dc.identifier.doi10.1002/bies.201700015-
dc.description.resumoIn this manuscript we describe Proteogenomics Viewer, a web-based tool that collects MS peptide identification, indexes to genomic sequence and structure, assigns exon usage, reports the identified protein isoforms with genomic alignments and, most importantly, allows the inspection of MS2 information for proper peptide identification. It also provides all performed indexing to facilitate global analysis of the data. The relevance of such tool is that there has been an increase in the number of proteogenomic efforts to improve the annotation of both genomics and proteomics data, culminating with the release of the two human proteome drafts. It is now clear that mass spectrometry-based peptide identification of uncharacterized sequences, such as those resulting from unpredicted exon joints or non-coding regions, is still prone to a higher than expected false discovery rate. Therefore, proper visualization of the raw data and the corresponding genome alignments are fundamental for further data validation and interpretation.pt_BR
dc.description.embargo2020-12-
Appears in Collections:ICe - Artigos publicados em periódicos

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