1. Universidade Federal do Rio Grande do Norte
2. Centro de Biociências
3. DBF - Departamento de Biofísica e Farmacologia
4. CB - DBF - Artigos publicados em periódicos

Título:	Quality of life and adverse effects of olanzapine versus risperidone therapy in patients with schizophrenia
Autor(es):	Araújo, Aurigena Antunes de Chaves, Katarina Melo Serrano-Blanco, Antoni Ribeiro, Susana Barbosa Soares, Luiz Alberto Lira Guerra, Gerlane Coelho Bernardo Alves, Maria do Socorro Costa Feitosa Araújo Júnior, Raimundo Fernandes de Rachetti, Vanessa de Paula Soares Filgueira Júnior, Antônio
Palavras-chave:	Schizophrenia;Atypical antipsychotic;Quality of life
Data do documento:	18-Jul-2012
Editor:	Springer
Referência:	ARAÚJO, Aurigena Antunes de et al. Quality of life and adverse effects of olanzapine versus risperidone therapy in patients with schizophrenia. Psychiatric Quarterly, v. 84, p. 125-135, 2012. Disponível em: <https://link.springer.com/article/10.1007%2Fs11126-012-9233-3>. Acesso em: 15 mar. 2018.
Resumo:	This cross-sectional study aimed to compare the effects of treatment with an atypical antipsychotic drug (olanzapine or risperidone) on quality of life (QoL) and to document adverse effects in 115 patients diagnosed with schizophrenia who attended the ambulatory service of Hospital Dr. João Machado, Natal, Rio Grande do Norte, Brazil. Socioeconomic, sociodemographic, and clinical variables were compared. The QoL Scale validated for Brazil (QLS-BR) was used to evaluate QoL, and adverse effects were assessed using the Udvalg for Kliniske Undersøgelser Side Effect Rating Scale. Data were analyzed using the χ2 test and Student’s t test, with a significance level of 5 %. Patients in both drug groups showed severe impairment in the occupational domain of the QLS-BR. Global QLS-BR scores indicated impairment among risperidone users and severe impairment among olanzapine users. The most significant side effects were associated with risperidone, including asthenia/lassitude/fatigue, somnolence/sedation, paresthesia, change in visual accommodation, increased salivation, diarrhea, orthostatic posture, palpitations/tachycardia, erythema, photosensitivity, weight loss, galactorrhea, decreased sexual desire, erectile/orgasmic dysfunction, vaginal dryness, headache, and physical dependence. QoL was impaired in patients using olanzapine and in those using risperidone. Risperidone use was associated with psychic, neurological, and autonomous adverse effects and other side effects.
URI:	https://repositorio.ufrn.br/jspui/handle/123456789/25418
ISSN:	1573-6709
Aparece nas coleções:	CB - DBF - Artigos publicados em periódicos

Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.