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Title: Intestinal anti-inflammatory activity of goat milk and goat yoghurt in the acetic acid model of rat colitis
Authors: Araújo, Aurigena Antunes de
Assis, Paloma Oliveira Antonino de
Guerra, Gerlane Coelho Bernardo
Araújo, Daline Fernandes de Souza
Araújo Júnior, Raimundo Fernandes de
Machado, Tamires Alcântara Dourado Gomes
Lima, Tamires Alcoforado Sena de
Garcia, Hugo Enrique Mendez
Andrade, Leylliane de Fátima Leal Interaminense de
Queiroga, Rita de Cássia Ramos do Egypto
Keywords: goat milk-Intestinal anti-inflammatory activity;goat yoghurt-Intestinal anti-inflammatory;functional foods
Issue Date: May-2016
Publisher: Elsevier
Citation: ARAÚJO, Aurigena Antunes de et al. Intestinal anti-inflammatory activity of goat milk and goat yoghurt in the acetic acid model of rat colitis. International Dairy Journal, v. 56, p. 45-54, 2016. Disponível em: <>. Acesso em: 19 mar. 2018.
Portuguese Abstract: The intestinal anti-inflammatory effect of goat milk and goat yoghurt with addition of Lactobacillus acidophilus, with or without native bee honey, was evaluated in rats with 10% acetic acid-induced colitis. The pre-treatment with goat milk, goat yoghurt or sulfasalazine significantly improved the myeloperoxidase activity, levels of leukotriene B4 (LTB4), interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α). It also promoted a significant reduction in oxidative stress that could be seen by the reduction in malondialdehyde and the increase in glutathione. The benefit of the pre-treatments was also demonstrated in the preservation of colonic cytoarchitecture and the decreased expression of cyclooxygenase-2 and inducible nitric oxide synthase. These results suggest that goat milk and goat yoghurt exert protective effects similar to those of sulfasalazine on intestinal damage induced by acetic acid and that goat milk and goat yoghurt may act as functional foods in inflammatory bowel disease.
ISSN: 0958-6946
Appears in Collections:CB - DBF - Artigos publicados em periódicos

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