1. Universidade Federal do Rio Grande do Norte
2. Instituto do Cérebro
3. ICe - Artigos publicados em periódicos

Title:	m1 acetylcholine receptor expression is decreased in hippocampal CA1 region of aged epileptic animals
Authors:	Cavarsan, Clarissa Fantin Avanzi, Renata Della Torre Queiroz, Claudio Marcos Teixeira de Xavier, Gilberto Fernando Mello, Luiz Eugênio Covolan, Luciene
Keywords:	Aging;Epilepsy;Hippocampus;Pilocarpine;m1 ACh receptor
Issue Date:	Aug-2011
Citation:	CAVARSAN, C. F. et al. m1 acetylcholine receptor expression is decreased in hippocampal CA1 region of aged epileptic animals. Aging Dis, v. 2, n. 4, p. 301-307, ago./2011.
Portuguese Abstract:	n the present study, we investigated the possible additive effects of epilepsy and aging on the expression of m1 muscarinic acetylcholine receptors (AChR) in the rat hippocampus. Young (3 months) and Aged (20 months) male, Wistar rats were treated with pilocarpine to induce status epilepticus (SE). Immunohistochemical procedure for m1 AChR detection was performed 2 months after pilocarpine-induced SE. In the CA1 pyramidal region m1 AChR staining was significantly decreased in aged epileptic animals when compared to young epileptic and aged control rats, indicating that the aging effect is worsened by the epileptic condition. However, the Nissl-stained cell analysis indicated that the number of pyramidal CA1 neurons was similarly reduced in both epileptic groups, young and aged animals. Therefore, our data suggest that the progressive reduction of m1 AChR expression in CA1 pyramidal cells of aged epileptic rats might bear relevance to the associated progressive cognitive impairment.
URI:	https://repositorio.ufrn.br/jspui/handle/123456789/26109
ISSN:	2152-5250
Appears in Collections:	ICe - Artigos publicados em periódicos

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