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Title: Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation
Authors: Oliveira, Leticia Castelo Branco Peroba
Queiroz, Moacir Fernandes
Fidelis, Gabriel Pereira
Melo, Karoline Rachel Teodosio
Câmara, Rafael Barros Gomes da
Alves, Monique Gabriela das Chagas Faustino
Costa, Leandro Silva
Teixeira, Dárlio Inácio Alves
Melo-Silveira, Raniere Fagundes
Rocha, Hugo Alexandre de Oliveira
Keywords: Sulfated galactan;Red seaweed;Antioxidant;Calcium oxalate dihydrate crystals;Urolithiasis
Issue Date: 28-Apr-2020
Publisher: MDPI
Citation: OLIVEIRA, Leticia Castelo Branco Peroba; QUEIROZ, Moacir Fernandes; FIDELIS, Gabriel Pereira; MELO, Karoline Rachel Teodosio; CÂMARA, Rafael Barros Gomes; ALVES, Monique Gabriela Chagas Faustino; COSTA, Leandro Silva; TEIXEIRA, Dárlio Inácio Alves; MELO-SILVEIRA, Raniere Fagundes; ROCHA, Hugo Alexandre Oliveira. Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation. Molecules, [s. l.], v. 25, n. 9, p. 2055-2069, 28 abr. 2020. MDPI AG. Disponível em: Acesso em: 03 ago. 2020.
Portuguese Abstract: The genus Gracilaria synthesizes sulfated polysaccharides (SPs). Many of these SPs, including those synthesized by the edible seaweed Gracilaria birdiae, have not yet been adequately investigated for their use as potential pharmaceutical compounds. Previous studies have demonstrated the immunomodulatory effects of sulfated galactans from G. birdiae. In this study, a galactan (GB) was extracted from G. birdiae and evaluated by cell proliferation and antioxidant tests. GB showed no radical hydroxyl (OH) and superoxide (O2−) scavenging ability. However, GB was able to donate electrons in two further different assays and presented iron- and copper-chelating activity. Urolithiasis affects approximately 10% of the world’s population and is strongly associated with calcium oxalate (CaOx) crystals. No efficient compound is currently available for the treatment of this disease. GB appeared to interact with and stabilize calcium oxalate dihydrate crystals, leading to the modification of their morphology, size, and surface charge. These crystals then acquired the same characteristics as those found in healthy individuals. In addition, GB showed no cytotoxic effect against human kidney cells (HEK-293). Taken together, our current findings highlight the potential application of GB as an antiurolithic agent
ISSN: 1420-3049 (online)
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EAJ - Artigos publicados em periódicos
EMCM - Artigos publicados em periódicos

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