Please use this identifier to cite or link to this item: https://repositorio.ufrn.br/handle/123456789/31190
Title: In vitro studies reveal antiurolithic effect of antioxidant sulfated polysaccharides from the green seaweed Caulerpa cupressoides var flabellata
Authors: Gomes, Dayanne Lopes
Melo, Karoline Rachel Teodosio
Queiroz, Moacir Fernandes
Batista, Lucas Alighieri Neves Costa
Santos, Pablo Castro
Costa, Mariana Santana Santos Pereira
Almeida-Lima, Jailma
Câmara, Rafael Barros Gomes da
Costa, Leandro Silva
Rocha, Hugo Alexandre de Oliveira
Keywords: Urolithiasis;Green algae;COD dumbbell;COD stabilization
Issue Date: 1-Jun-2019
Publisher: MDPI
Citation: GOMES, Dayanne Lopes; MELO, Karoline Rachel Teodosio; QUEIROZ, Moacir Fernandes; BATISTA, Lucas Alighieri Neves Costa; SANTOS, Pablo Castro; COSTA, Mariana Santana Santos Pereira; ALMEIDA-LIMA, Jailma; CAMARA, Rafael Barros Gomes da; COSTA, Leandro Silva; ROCHA, Hugo Alexandre de Oliveira. In vitro studies reveal antiurolithic effect of antioxidant sulfated polysaccharides from the green seaweed Caulerpa cupressoides var flabellata. Marine Drugs, [s. l.], v. 17, n. 6, p. 326-341, 1 jun. 2019. MDPI AG. Disponível em: https://www.mdpi.com/1660-3397/17/6/326. Acesso em: 03 ago. 2020. http://dx.doi.org/10.3390/md17060326.
Portuguese Abstract: Urolithiasis affects approximately 10% of the world population and is strongly associated with calcium oxalate (CaOx) crystals. Currently, there is no efficient compound that can be used to prevent this disease. However, seaweeds’ sulfated polysaccharides (SPs) can change the CaOx crystals surface’s charge and thus modify the crystallization dynamics, due to the interaction of the negative charges of these polymers with the crystal surface during their synthesis. We observed that the SPs of Caulerpa cupressoides modified the morphology, size and surface charge of CaOx crystals. Thus, these crystals became similar to those found in healthy persons. In the presence of SPs, dihydrate CaOx crystals showed rounded or dumbbell morphology. Infrared analysis, fluorescence microscopy, flow cytometry (FITC-conjugated SPs) and atomic composition analysis (EDS) allowed us to propose the mode of action between the Caulerpa’s SPs and the CaOx crystals. This study is the first step in understanding the interactions between SPs, which are promising molecules for the treatment of urolithiasis, and CaOx crystals, which are the main cause of kidney stones
URI: https://repositorio.ufrn.br/handle/123456789/31190
ISSN: 1660-3397 (online)
Appears in Collections:CB - DBQ - Artigos publicados em periódicos
EMCM - Artigos publicados em periódicos

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