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Title: mTOR inhibition impairs extinction memory reconsolidation
Authors: Radiske, Andressa
Gonzalez, Maria Carolina
Ferreira, Diana Aline Nôga Morais
Rossato, Janine Inez
Bevilaqua, Lia Rejane Müller
Cammarota, Martín Pablo
Keywords: Memory reconsolidation;Brain-derived neurotrophic factor;BDNF;TOR Serine-threonine kinases;Mammalian target of rapamycin
Issue Date: 15-Dec-2020
Publisher: Cold Spring Harbor Laboratory
Citation: RADISKE, Andressa; GONZALEZ, Maria Carolina; NÔGA, Diana A.; ROSSATO, Janine I.; BEVILAQUA, Lia R. M.; CAMMAROTA, Martín. mTOR inhibition impairs extinction memory reconsolidation. Learning & Memory, [S. l.], v. 28, n. 1, p. 1-6, dez. 2020. doi: Disponível em: Acesso em: 07 jan. 2021.
Portuguese Abstract: Fear-motivated avoidance extinction memory is prone to hippocampal brain-derived neurotrophic factor (BDNF)-dependent reconsolidation upon recall. Here, we show that extinction memory recall activates mammalian target of rapamycin (mTOR) in dorsal CA1, and that post-recall inhibition of this kinase hinders avoidance extinction memory persistence and recovers the learned aversive response. Importantly, coadministration of recombinant BDNF impedes the behavioral effect of hippocampal mTOR inhibition. Our results demonstrate that mTOR signaling is necessary for fear-motivated avoidance extinction memory reconsolidation and suggests that BDNF acts downstream mTOR in a protein synthesis-independent manner to maintain the reactivated extinction memory trace
Appears in Collections:ICe - Artigos publicados em periódicos

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