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Title: Heterofucan from Sargassum filipendula induces apoptosis in HeLa cells
Authors: Costa, Leandro Silva
Telles, Cinthia Beatrice Silva
Oliveira, Ruth Medeiros
Nobre, Leonardo Thiago Duarte Barreto
Dantas-Santos, Nednaldo
Câmara, Rafael Barros Gomes da
Costa, Mariana Santana Santos Pereira
Almeida-Lima, Jailma
Melo-Silveira, Raniere Fagundes
Albuquerque, Ivan Rui Lopes
Leite, Edda Lisboa
Rocha, Hugo Alexandre de Oliveira
Keywords: Fucoidan;Sulfated polysaccharides;Anticancer;Apoptosis-inducing factor (AIF)
Issue Date: 14-Apr-2011
Publisher: MDPI
Citation: COSTA, Leandro Silva; TELLES, Cinthia Beatrice Silva; OLIVEIRA, Ruth Medeiros; NOBRE, Leonardo Thiago Duarte Barreto; DANTAS-SANTOS, Nednaldo; CAMARA, Rafael Barros Gomes da; COSTA, Mariana Santana Santos Pereira; ALMEIDA-LIMA, Jailma; MELO-SILVEIRA, Raniere Fagundes; ALBUQUERQUE, Ivan Rui Lopes. Heterofucan from Sargassum filipendula induces apoptosis in HeLa cells. Marine Drugs, [s. l.], v. 9, n. 4, p. 603-614, 14 abr. 2011. MDPI AG. Disponível em: Acesso em: 16 set. 2020.
Portuguese Abstract: Fucan is a term used to denominate a family of sulfated polysaccharides rich in sulfated L-fucose. Heterofucan SF-1.5v was extracted from the brown seaweed Sargassum filipendula by proteolytic digestion followed by sequential acetone precipitation. This fucan showed antiproliferative activity on Hela cells and induced apoptosis. However, SF-1.5v was not able to activate caspases. Moreover, SF-1.5v induced glycogen synthase kinase (GSK) activation, but this protein is not involved in the heterofucan SF-1.5v induced apoptosis mechanism. In addition, ERK, p38, p53, pAKT and NFκB were not affected by the presence of SF-1.5v. We determined that SF-1.5v induces apoptosis in HeLa mainly by mitochondrial release of apoptosis-inducing factor (AIF) into cytosol. In addition, SF-1.5v decreases the expression of anti-apoptotic protein Bcl-2 and increased expression of apoptogenic protein Bax. These results are significant in that they provide a mechanistic framework for further exploring the use of SF-1.5v as a novel chemotherapeutics against human cervical cancer
ISSN: 1660-3397 (online)
Appears in Collections:CB - DBQ - Artigos publicados em periódicos

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