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Title: Anticoagulant, antioxidant and antitumor activities of heterofucans from the seaweed Dictyopteris delicatula
Authors: Magalhaes, Kaline Dantas
Costa, Leandro Silva
Fidelis, Gabriel Pereira
Oliveira, Ruth Medeiros
Nobre, Leonardo Thiago Duarte Barreto
Dantas-Santos, Nednaldo
Câmara, Rafael Barros Gomes da
Albuquerque, Ivan Rui Lopes
Cordeiro, Sara Lima
Sabry, Diego Araujo
Costa, Mariana Santana Santos Pereira
Alves, Luciana Guimaraes
Rocha, Hugo Alexandre de Oliveira
Keywords: Fucoidan;Brown seaweed;Biological activities;Sulfated polysaccharides
Issue Date: 23-May-2011
Publisher: MDPI
Citation: MAGALHÃES, Kaline Dantas; COSTA, Leandro Silva; FIDELIS, Gabriel Pereira; OLIVEIRA, Ruth Medeiros; NOBRE, Leonardo Thiago Duarte Barreto; DANTAS-SANTOS, Nednaldo; CAMARA, Rafael Barros Gomes da; ALBUQUERQUE, Ivan Rui Lopes; CORDEIRO, Sara Lima; SABRY, Diego Araujo; COSTA, Mariana Santana Santos Pereira; ALVES, Luciana Guimaraes; ROCHA, Hugo Alexandre de Oliveira. Anticoagulant, antioxidant and antitumor activities of heterofucans from the seaweed Dictyopteris delicatula. International Journal of Molecular Sciences, [s. l.], v. 12, p. 3352-3365, 2011. Disponível em: Acesso em: 25 set. 2020.
Portuguese Abstract: In the present study, six families of sulfated polysaccharides were obtained from seaweed Dictyopteris delicatula by proteolytic digestion, followed by acetone fractionation and molecular sieving on Sephadex G-100. Chemical analyses demonstrated that all polysaccharides contain heterofucans composed mainly of fucose, xylose, glucose, galactose, uronic acid, and sulfate. The fucans F0.5v and F0.7v at 1.0 mg/mL showed high ferric chelating activity (~45%), whereas fucans F1.3v (0.5 mg/mL) showed considerable reducing power, about 53.2% of the activity of vitamin C. The fucan F1.5v presented the most prominent anticoagulant activity. The best antiproliferative activity was found with fucans F1.3v and F0.7v. However, F1.3v activity was much higher than F0.7v inhibiting almost 100% of HeLa cell proliferation. These fucans have been selected for further studies on structural characterization as well as in vivo experiments, which are already in progress
ISSN: 1422-0067 (online)
1661-6596 (print)
Appears in Collections:CB - DBQ - Artigos publicados em periódicos

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