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Title: The impact of body mass on inflammatory markers and insulin resistance in polycystic ovary syndrome
Authors: Santos, Ana Celly Souza dos
Soares, Nayara Pereira
Costa, Eduardo Caldas
Sá, Joceline Cássia Ferrezini de
Azevedo, George Dantas de
Lemos, Telma Maria Araújo Moura
Keywords: Cytokines;Inflammation;Insulin resistance;Nutritional status;Obesity;Ovary;Polycystic ovary syndrome
Issue Date: 6-Nov-2015
Publisher: Taylor and Francis
Citation: SANTOS, Ana Celly Souza dos; SOARES, Nayara Pereira; COSTA, Eduardo Caldas; SÁ, Joceline Cássia Ferrezini de; AZEVEDO, George Dantas de; LEMOS, Telma Maria Araújo Moura. The impact of body mass on inflammatory markers and insulin resistance in polycystic ovary syndrome. Gynecological Endocrinology, [s. l.], v. 31, n. 3, p. 225-228, 6 nov. 2015. Disponível em: Acesso em: 02 jul. 2020.
Portuguese Abstract: Objective: to evaluate inflammatory markers and insulin resistance (IR) in women with and without polycystic ovary syndrome (PCOS), with different body mass index (BMI). Methods: tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6) and C-reactive protein (CRP) were assessed in serum samples from 40 women in reproductive age. Patients were divided into four groups: I (non-eutrophic with PCOS, n¼12), II (non-eutrophic without PCOS, n¼10), III (eutrophic with PCOS, n¼8) and IV (eutrophic without PCOS, n¼10) being non-eutrophic, the overweight and obese women with BMI425 kg/m2 and eutrophic women with BMI524.9 kg/m2. Homeostatic model assessment (HOMA-IR) was calculated for evaluation of IR. Results: PCOS patients showed increased levels of CRP (p50.01) and HOMA-IR (p50.01). When divided by BMI, both non-eutrophic and eutrophic PCOS showed increased CRP levels (p50.01) and HOMA-IR (p50.01). There were no differences in TNF-a and IL-6 levels between groups. Conclusion: in the PCOS group, the levels of CRP and IR were elevated, compared to their counterparts, regardless of body mass
ISSN: 0951-3590
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