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Title: Effects of Mucuna pruriens (L.) supplementation on experimental models of parkinson's disease: a systematic review
Authors: Idalina Neta, Francisca
Costa, Ianara Mendonça da
Lima, Francisca Overlânia Vieira
Fernandes, Luciana Cristina Borges
Cavalcanti, José Rodolfo Lopes de Paiva
Freire, Marco Aurélio de Moura
Lucena, Eudes Euler De Souza
Rêgo, Amália Cinthia Meneses do
Araújo Filho, Irami
Azevedo, Eduardo Pereira de
Guzen, Fausto Pierdoná
Keywords: Antioxidant;Mucuna pruriens (L.) DC;Neuroprotection;Parkinson’s disease
Issue Date: 2018
Publisher: Medknow Publications
Citation: IDALINA NETA, Francisca; COSTA, Ianara Mendonça da; LIMA, Francisca Overlânia Vieira; FERNANDES, Luciana Cristina Borges; CAVALCANTI, José Rodolfo Lopes de Paiva; FREIRE, Marco Aurélio de Moura; LUCENA, Eudes Euler de Souza; RÊGO, Amália Cinthia Meneses do; ARAÚJO FILHO, Irami; GUZEN, Fausto Pierdoná. Effects of Mucuna pruriens (L.) supplementation on experimental models of parkinson's disease: a systematic review. Pharmacognosy Reviews, [s. l.], v. 12, n. 23, p. 78, 2018. Medknow. Disponível em: Acesso em: 16 jul. 2020.
Portuguese Abstract: Introduction: Mucuna pruriens (L.)DC. (Mp) has been used in the treatment of numerous diseases in Indian Ayurvedic medicine, mainly for delaying the symptoms of Parkinson’s disease (PD), and has as its main component levodopa (L‑DOPA). The aim of this work is to systematically review the effects of Mp supplementation on experimental models of PD due to its neuroprotective and antioxidant properties. MATERIALS AND Methods: The search was conducted through PubMed, ScienceDirect, Cochrane Library, and Scientific Electronic Library Online databases, where a number of relevant articles were found. Results: Mp demonstrated significant positive responses in the experimental models of PD by improving motor deficits and by enhancing the activity of the antioxidant systems, reducing oxidative stress. In addition, it presented some advantages when compared to a conventional antiparkinsonian drug as it minimized the occurrence and severity of dyskinesias. Conclusion: Thus, considering that the use of herbal medicines decreases the likelihood of side effects associated with the pharmaceutical drugs, this work aims to summarize and evaluate the data available regarding the mechanism of action of Mp and the reported benefits of this plant as an alternative to improve the quality of life of individuals with PD
ISSN: 0973-7847 (print)
0976-2787 (0nline)
Appears in Collections:CCS - DCIRUR - Artigos publicados em periódicos
EMCM - Artigos publicados em periódicos

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