1. Universidade Federal do Rio Grande do Norte
2. Instituto do Cérebro
3. ICe - Artigos publicados em periódicos

Título:	Differential expression levels of Sox9 in early neocortical radial glial cells regulate the decision between stem cell maintenance and differentiation
Autor(es):	Fabra-Beser, Jaime Araújo, Jéssica Alves de Medeiros Coelho, Diego Marques Goff, Loyal A. Costa, Marcos Romualdo Müller, Ulrich Gil-Sanz, Cristina
Palavras-chave:	Cortical development;Progenitors diversity;Radial glia cells;Sox9
Data do documento:	18-Ago-2021
Editor:	Society for Neuroscience
Referência:	FABRA-BESER, Jaime; ARAUJO, Jessica Alves Medeiros de; MARQUES-COELHO, Diego; GOFF, Loyal A.; COSTA, Marcos R.; MÜLLER, Ulrich; GIL-SANZ, Cristina. Differential Expression Levels of Sox9 in Early Neocortical Radial Glial Cells Regulate the Decision between Stem Cell Maintenance and Differentiation. The Journal Of Neuroscience, [S. l.], v. 41, n. 33, p. 6969-6986, ago. 2021. http://dx.doi.org/10.1523/jneurosci.2905-20.2021. Disponível em: https://www.jneurosci.org/content/41/33/6969#page. Acesso em: 23 ago. 2021.
Resumo:	Radial glial progenitor cells (RGCs) in the dorsal telencephalon directly or indirectly produce excitatory projection neurons and macroglia of the neocortex. Recent evidence shows that the pool of RGCs is more heterogeneous than originally thought and that progenitor subpopulations can generate particular neuronal cell types. Using single-cell RNA sequencing, we have studied gene expression patterns of RGCs with different neurogenic behavior at early stages of cortical development. At this early age, some RGCs rapidly produce postmitotic neurons, whereas others self-renew and undergo neurogenic divisions at a later age. We have identified candidate genes that are differentially expressed among these early RGC subpopulations, including the transcription factor Sox9. Using in utero electroporation in embryonic mice of either sex, we demonstrate that elevated Sox9 expression in progenitors affects RGC cell cycle duration and leads to the generation of upper layer cortical neurons. Our data thus reveal molecular differences between progenitor cells with different neurogenic behavior at early stages of corticogenesis and indicates that Sox9 is critical for the maintenance of RGCs to regulate the generation of upper layer neurons
URI:	https://repositorio.ufrn.br/handle/123456789/33238
Aparece nas coleções:	ICe - Artigos publicados em periódicos

Este item está licenciada sob uma Licença Creative Commons